Motif ID: IRX3

Z-value: 0.850


Transcription factors associated with IRX3:

Gene SymbolEntrez IDGene Name
IRX3 ENSG00000177508.11 IRX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_543207150.048.4e-01Click!


Activity profile for motif IRX3.

activity profile for motif IRX3


Sorted Z-values histogram for motif IRX3

Sorted Z-values for motif IRX3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_69681710 2.233 ENST00000265403.7
ENST00000458688.2
 UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr2_-_89545079 1.348 ENST00000468494.1
 IGKV2-30
immunoglobulin kappa variable 2-30
chr12_-_91573132 1.126 ENST00000550563.1
ENST00000546370.1
 DCN

decorin

chr4_+_70861647 1.105 ENST00000246895.4
ENST00000381060.2
 STATH

statherin

chr10_+_118187379 1.086 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_91574142 1.072 ENST00000547937.1
 DCN
decorin
chr19_-_9092018 1.067 ENST00000397910.4
 MUC16
mucin 16, cell surface associated
chr4_+_69962185 1.051 ENST00000305231.7
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr4_-_70080449 1.010 ENST00000446444.1
 UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr4_-_70725856 0.990 ENST00000226444.3
 SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr13_-_20080080 0.985 ENST00000400103.2
 TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr2_+_89975669 0.977 ENST00000474213.1
 IGKV2D-30
immunoglobulin kappa variable 2D-30
chr9_+_105757590 0.976 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr10_+_118305435 0.962 ENST00000369221.2
 PNLIP
pancreatic lipase
chr4_+_70146217 0.921 ENST00000335568.5
ENST00000511240.1
 UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr19_-_22379753 0.910 ENST00000397121.2
 ZNF676
zinc finger protein 676
chr5_+_140235469 0.870 ENST00000506939.2
ENST00000307360.5
 PCDHA10

protocadherin alpha 10

chr13_+_25254545 0.866 ENST00000218548.6
 ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr12_-_10282836 0.845 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
 CLEC7A


C-type lectin domain family 7, member A


chrX_-_15620192 0.832 ENST00000427411.1
 ACE2
angiotensin I converting enzyme 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 3.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 2.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 1.9 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 1.7 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 1.5 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 1.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.1 GO:0046541 saliva secretion(GO:0046541)
0.0 1.1 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.3 1.0 GO:0006711 estrogen catabolic process(GO:0006711)
0.1 1.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.0 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 1.0 GO:0008210 estrogen metabolic process(GO:0008210)
0.1 0.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 0.8 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.8 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.8 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.1 0.7 GO:2001206 positive regulation of osteoclast development(GO:2001206)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.4 1.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 1.2 GO:0097512 cardiac myofibril(GO:0097512)
0.3 1.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.1 0.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.5 GO:0097513 myosin II filament(GO:0097513)
0.0 0.5 GO:0001520 outer dense fiber(GO:0001520)
0.2 0.4 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.3 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 0.3 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 3.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 3.1 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 2.0 GO:0003823 antigen binding(GO:0003823)
0.1 1.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 1.6 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1 1.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.3 1.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 1.0 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 1.0 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 1.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 1.0 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 1.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.1 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 3.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.9 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 1.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.4 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.0 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.0 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts