Motif ID: IRX5

Z-value: 0.469


Transcription factors associated with IRX5:

Gene SymbolEntrez IDGene Name
IRX5 ENSG00000176842.10 IRX5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX5hg19_v2_chr16_+_54964740_549647890.359.7e-02Click!


Activity profile for motif IRX5.

activity profile for motif IRX5


Sorted Z-values histogram for motif IRX5

Sorted Z-values for motif IRX5



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_58329819 1.614 ENST00000551421.1
 RP11-620J15.3
RP11-620J15.3
chr7_-_99573677 1.375 ENST00000292401.4
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr7_-_99573640 1.356 ENST00000411734.1
 AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr2_+_228735763 1.222 ENST00000373666.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr16_+_19467772 1.189 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
 TMC5


transmembrane channel-like 5


chr13_+_97928395 0.973 ENST00000445661.2
 MBNL2
muscleblind-like splicing regulator 2
chr15_-_56757329 0.904 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr13_-_36429763 0.883 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr3_-_9994021 0.863 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr13_+_50589390 0.862 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr3_+_100354442 0.786 ENST00000475887.1
 GPR128
G protein-coupled receptor 128
chr20_-_3762087 0.779 ENST00000379756.3
 SPEF1
sperm flagellar 1
chr6_-_52705641 0.712 ENST00000370989.2
 GSTA5
glutathione S-transferase alpha 5
chr13_-_20080080 0.668 ENST00000400103.2
 TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr7_-_138348969 0.659 ENST00000436657.1
 SVOPL
SVOP-like
chr10_+_127661942 0.646 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
 FANK1


fibronectin type III and ankyrin repeat domains 1


chr4_+_41361616 0.643 ENST00000513024.1
 LIMCH1
LIM and calponin homology domains 1
chr9_+_105757590 0.594 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr3_+_160473996 0.582 ENST00000498165.1
 PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr8_-_108510224 0.569 ENST00000517746.1
ENST00000297450.3
 ANGPT1

angiopoietin 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 1.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.0 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.9 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.9 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.6 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.6 GO:0055085 transmembrane transport(GO:0055085)
0.2 0.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 0.5 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 0.4 GO:0060480 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.2 GO:0016095 polyprenol catabolic process(GO:0016095)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2 0.6 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.6 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.0 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 1.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 0.5 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 0.4 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.2 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.2 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0044549 GTP cyclohydrolase binding(GO:0044549)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis