Motif ID: IRX6_IRX4

Z-value: 0.335

Transcription factors associated with IRX6_IRX4:

Gene SymbolEntrez IDGene Name
IRX4 ENSG00000113430.5 IRX4
IRX6 ENSG00000159387.7 IRX6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.405.4e-02Click!


Activity profile for motif IRX6_IRX4.

activity profile for motif IRX6_IRX4


Sorted Z-values histogram for motif IRX6_IRX4

Sorted Z-values for motif IRX6_IRX4



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX6_IRX4

PNG image of the network

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Top targets:


Showing 1 to 20 of 71 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_777118 0.818 ENST00000562141.1
 HAGHL
hydroxyacylglutathione hydrolase-like
chr3_-_9994021 0.632 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr1_+_63989004 0.621 ENST00000371088.4
 EFCAB7
EF-hand calcium binding domain 7
chr21_-_34185944 0.516 ENST00000479548.1
 C21orf62
chromosome 21 open reading frame 62
chr11_+_6897856 0.505 ENST00000379829.2
 OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr16_+_777246 0.446 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
 HAGHL




hydroxyacylglutathione hydrolase-like




chr16_+_776936 0.409 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
 HAGHL



hydroxyacylglutathione hydrolase-like



chr20_+_11008408 0.397 ENST00000378252.1
 C20orf187
chromosome 20 open reading frame 187
chr12_+_32655110 0.371 ENST00000546442.1
ENST00000583694.1
 FGD4

FYVE, RhoGEF and PH domain containing 4

chr8_+_67976593 0.350 ENST00000262210.5
ENST00000412460.1
 CSPP1

centrosome and spindle pole associated protein 1

chr12_-_10282836 0.325 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
 CLEC7A


C-type lectin domain family 7, member A


chr4_+_41361616 0.296 ENST00000513024.1
 LIMCH1
LIM and calponin homology domains 1
chr6_-_52705641 0.270 ENST00000370989.2
 GSTA5
glutathione S-transferase alpha 5
chr7_-_16844611 0.259 ENST00000401412.1
ENST00000419304.2
 AGR2

anterior gradient 2

chr1_+_170904612 0.257 ENST00000367759.4
ENST00000367758.3
 MROH9

maestro heat-like repeat family member 9

chr12_-_10282681 0.225 ENST00000533022.1
 CLEC7A
C-type lectin domain family 7, member A
chr3_+_171561127 0.223 ENST00000334567.5
ENST00000450693.1
 TMEM212

transmembrane protein 212

chr12_-_10282742 0.215 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A


C-type lectin domain family 7, member A


chrX_+_36254051 0.204 ENST00000378657.4
 CXorf30
chromosome X open reading frame 30
chr13_-_41768654 0.176 ENST00000379483.3
 KBTBD7
kelch repeat and BTB (POZ) domain containing 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.3 GO:0060480 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.1 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.1 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)

Gene overrepresentation in cellular_component category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular_function category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)