Motif ID: ISL1

Z-value: 0.494


Transcription factors associated with ISL1:

Gene SymbolEntrez IDGene Name
ISL1 ENSG00000016082.10 ISL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ISL1hg19_v2_chr5_+_50678921_50678921-0.203.4e-01Click!


Activity profile for motif ISL1.

activity profile for motif ISL1


Sorted Z-values histogram for motif ISL1

Sorted Z-values for motif ISL1



Network of associatons between targets according to the STRING database.



First level regulatory network of ISL1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102668879 0.946 ENST00000315274.6
 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr8_+_26371763 0.736 ENST00000521913.1
 DPYSL2
dihydropyrimidinase-like 2
chrX_+_135252050 0.612 ENST00000449474.1
ENST00000345434.3
 FHL1

four and a half LIM domains 1

chr12_-_30887948 0.600 ENST00000433722.2
 CAPRIN2
caprin family member 2
chrX_+_135251835 0.562 ENST00000456445.1
 FHL1
four and a half LIM domains 1
chr5_+_137203465 0.556 ENST00000239926.4
 MYOT
myotilin
chrX_+_135251783 0.551 ENST00000394153.2
 FHL1
four and a half LIM domains 1
chr19_-_50143452 0.547 ENST00000246792.3
 RRAS
related RAS viral (r-ras) oncogene homolog
chr6_+_167704838 0.445 ENST00000366829.2
 UNC93A
unc-93 homolog A (C. elegans)
chrX_+_79675965 0.436 ENST00000308293.5
 FAM46D
family with sequence similarity 46, member D
chr11_+_60995849 0.408 ENST00000537932.1
 PGA4
pepsinogen 4, group I (pepsinogen A)
chr16_-_67517716 0.405 ENST00000290953.2
 AGRP
agouti related protein homolog (mouse)
chr6_+_167704798 0.399 ENST00000230256.3
 UNC93A
unc-93 homolog A (C. elegans)
chr2_-_208030647 0.388 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr22_+_40390930 0.379 ENST00000333407.6
 FAM83F
family with sequence similarity 83, member F
chr4_+_8201091 0.372 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
 SH3TC1



SH3 domain and tetratricopeptide repeats 1



chr10_-_17659234 0.367 ENST00000466335.1
 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr3_+_121774202 0.343 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
 CD86



CD86 molecule



chr2_+_211421262 0.338 ENST00000233072.5
 CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr9_-_113761720 0.337 ENST00000541779.1
ENST00000374430.2
 LPAR1

lysophosphatidic acid receptor 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.0 0.9 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.3 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.3 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.3 GO:0048749 compound eye development(GO:0048749)
0.1 0.3 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 0.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.2 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.3 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.0 0.1 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 0.7 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.3 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones