Motif ID: ISL2

Z-value: 0.355


Transcription factors associated with ISL2:

Gene SymbolEntrez IDGene Name
ISL2 ENSG00000159556.5 ISL2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_766290730.164.5e-01Click!


Activity profile for motif ISL2.

activity profile for motif ISL2


Sorted Z-values histogram for motif ISL2

Sorted Z-values for motif ISL2



Network of associatons between targets according to the STRING database.



First level regulatory network of ISL2

PNG image of the network

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Top targets:


Showing 1 to 20 of 146 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_163008903 0.800 ENST00000418842.2
ENST00000375497.3
 GCG

glucagon

chr4_+_169013666 0.675 ENST00000359299.3
 ANXA10
annexin A10
chr13_-_20806440 0.662 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6


gap junction protein, beta 6, 30kDa


chr11_-_107729887 0.581 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr5_-_139726181 0.576 ENST00000507104.1
ENST00000230990.6
 HBEGF

heparin-binding EGF-like growth factor

chr11_-_28129656 0.574 ENST00000263181.6
 KIF18A
kinesin family member 18A
chrX_+_96138907 0.443 ENST00000373040.3
 RPA4
replication protein A4, 30kDa
chr2_-_10587897 0.429 ENST00000405333.1
ENST00000443218.1
 ODC1

ornithine decarboxylase 1

chr4_-_69111401 0.404 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr3_+_172468505 0.360 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
 ECT2




epithelial cell transforming sequence 2 oncogene




chr2_+_105050794 0.328 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
 AC013402.2


long intergenic non-protein coding RNA 1102


chr3_+_172468472 0.321 ENST00000232458.5
ENST00000392692.3
 ECT2

epithelial cell transforming sequence 2 oncogene

chr12_-_95945246 0.310 ENST00000258499.3
 USP44
ubiquitin specific peptidase 44
chr7_-_111032971 0.301 ENST00000450877.1
 IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr20_+_30102231 0.300 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
 HM13




histocompatibility (minor) 13




chr7_+_13141097 0.282 ENST00000411542.1
 AC011288.2
AC011288.2
chr21_+_39644305 0.269 ENST00000398930.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_39644395 0.264 ENST00000398934.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_141747950 0.262 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_130339710 0.261 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.8 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.7 GO:0051602 response to electrical stimulus(GO:0051602)
0.1 0.6 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.6 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.1 0.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.2 GO:0030035 microspike assembly(GO:0030035)
0.0 0.2 GO:0048840 otolith development(GO:0048840)
0.0 0.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.6 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines