Motif ID: JUN

Z-value: 1.482


Transcription factors associated with JUN:

Gene SymbolEntrez IDGene Name
JUN ENSG00000177606.5 JUN

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
JUNhg19_v2_chr1_-_59249732_59249785-0.414.7e-02Click!


Activity profile for motif JUN.

activity profile for motif JUN


Sorted Z-values histogram for motif JUN

Sorted Z-values for motif JUN



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_76899275 7.061 ENST00000322630.2
ENST00000586713.1
 DDC8

Protein DDC8 homolog

chr19_-_51014345 5.563 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
 JOSD2


Josephin domain containing 2


chr14_+_68086515 5.530 ENST00000261783.3
 ARG2
arginase 2
chr2_-_216300784 5.357 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr8_-_10697281 5.345 ENST00000553390.1
ENST00000524114.1
ENST00000554914.1
 SOX7
PINX1
SOX7
SRY (sex determining region Y)-box 7
PIN2/TERF1 interacting, telomerase inhibitor 1
Transcription factor SOX-7; Uncharacterized protein; cDNA FLJ58508, highly similar to Transcription factor SOX-7
chr4_+_75310851 4.785 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr4_+_75311019 4.688 ENST00000502307.1
 AREG
amphiregulin
chr1_+_17531614 4.470 ENST00000375471.4
 PADI1
peptidyl arginine deiminase, type I
chr19_-_51014460 4.399 ENST00000595669.1
 JOSD2
Josephin domain containing 2
chr1_+_152956549 4.266 ENST00000307122.2
 SPRR1A
small proline-rich protein 1A
chr20_+_34203794 3.919 ENST00000374273.3
 SPAG4
sperm associated antigen 4
chr2_-_216257849 3.775 ENST00000456923.1
 FN1
fibronectin 1
chr7_+_5632436 3.730 ENST00000340250.6
ENST00000382361.3
 FSCN1

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

chr1_+_152974218 3.509 ENST00000331860.3
ENST00000443178.1
ENST00000295367.4
 SPRR3


small proline-rich protein 3


chr4_+_75480629 3.472 ENST00000380846.3
 AREGB
amphiregulin B
chr1_+_151030234 3.465 ENST00000368921.3
 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_-_122744998 3.459 ENST00000274026.5
 CCNA2
cyclin A2
chr14_-_24732368 3.390 ENST00000544573.1
 TGM1
transglutaminase 1
chr14_-_24732403 3.252 ENST00000206765.6
 TGM1
transglutaminase 1
chr2_+_11864458 2.979 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
 LPIN1


lipin 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 276 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 9.5 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 9.5 GO:0016579 protein deubiquitination(GO:0016579)
3.0 9.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 7.9 GO:0018149 peptide cross-linking(GO:0018149)
1.3 7.5 GO:0030035 microspike assembly(GO:0030035)
0.1 7.0 GO:0030574 collagen catabolic process(GO:0030574)
2.2 6.6 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.3 6.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
1.1 5.7 GO:1904751 positive regulation of telomeric DNA binding(GO:1904744) positive regulation of protein localization to nucleolus(GO:1904751)
0.4 5.5 GO:0000050 urea cycle(GO:0000050)
0.9 4.5 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.7 4.4 GO:0055064 chloride ion homeostasis(GO:0055064)
0.5 4.4 GO:0002329 pre-B cell differentiation(GO:0002329)
0.7 4.3 GO:0051012 microtubule sliding(GO:0051012)
0.2 3.9 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.3 3.8 GO:0071314 cellular response to cocaine(GO:0071314)
0.3 3.7 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.2 3.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.2 3.5 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 3.5 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.5 GO:0001533 cornified envelope(GO:0001533)
0.1 11.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.7 9.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 8.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.5 6.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 6.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 6.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 6.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.7 5.2 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.0 5.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.6 4.8 GO:0031523 Myb complex(GO:0031523)
0.0 4.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.4 GO:0031968 organelle outer membrane(GO:0031968)
0.7 3.7 GO:0044393 microspike(GO:0044393)
0.0 3.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.6 GO:0005637 nuclear inner membrane(GO:0005637)
1.2 3.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 3.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 3.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 3.2 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 10.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 9.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 9.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 7.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 6.9 GO:0003779 actin binding(GO:0003779)
0.7 6.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 6.6 GO:0004305 ethanolamine kinase activity(GO:0004305)
1.2 6.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.5 6.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 6.0 GO:0051015 actin filament binding(GO:0051015)
0.1 5.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.9 4.5 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.3 4.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 4.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 4.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 3.9 GO:0043495 protein anchor(GO:0043495)
0.1 3.7 GO:0003785 actin monomer binding(GO:0003785)
1.2 3.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.2 3.5 GO:0036374 glutathione hydrolase activity(GO:0036374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 9.4 NABA_COLLAGENS Genes encoding collagen proteins
0.3 9.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 7.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 7.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 4.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.5 PID_CDC42_PATHWAY CDC42 signaling events
0.1 3.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 3.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 2.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.2 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.1 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 2.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 2.1 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.8 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.4 9.6 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 9.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 5.5 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 4.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 4.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 4.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 4.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.8 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 3.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 3.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.9 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 2.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 2.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones