Motif ID: KLF1
Z-value: 1.321
Transcription factors associated with KLF1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| KLF1 | ENSG00000105610.4 | KLF1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg19_v2_chr19_-_12997995_12998021 | -0.19 | 3.8e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 191 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.3 | GO:0070268 | cornification(GO:0070268) |
| 1.2 | 9.9 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 1.9 | 9.7 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.3 | 7.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 5.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.2 | 4.9 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.3 | 4.2 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.8 | 3.9 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.4 | 3.8 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 3.5 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 3.5 | GO:0042177 | negative regulation of protein catabolic process(GO:0042177) |
| 0.2 | 3.4 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.4 | 3.2 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.1 | 3.1 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.5 | 3.0 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.2 | 2.9 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.6 | 2.8 | GO:0033078 | extrathymic T cell differentiation(GO:0033078) |
| 0.2 | 2.8 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 2.8 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 2.8 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 84 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 10.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.8 | 9.9 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.3 | 9.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 6.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 5.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 5.8 | GO:0043034 | costamere(GO:0043034) |
| 0.2 | 5.6 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 5.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.3 | 4.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 4.3 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 3.3 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.4 | 3.1 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 1.0 | 2.9 | GO:0034676 | integrin alpha6-beta4 complex(GO:0034676) |
| 0.1 | 2.8 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 2.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.7 | 2.6 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.2 | 2.5 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 2.5 | GO:0031430 | M band(GO:0031430) |
| 0.8 | 2.3 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 137 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.5 | 9.9 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 2.4 | 9.7 | GO:0030395 | lactose binding(GO:0030395) |
| 0.0 | 7.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 7.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 7.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 5.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 5.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 5.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 4.9 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 4.9 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.2 | 4.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 4.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 3.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.4 | 3.8 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.6 | 3.4 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.4 | 3.2 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 3.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 3.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 3.1 | GO:0019215 | intermediate filament binding(GO:0019215) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.9 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 9.9 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 8.6 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.5 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 6.1 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.3 | 6.0 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 4.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 4.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.3 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 3.4 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 3.3 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.1 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.4 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 2.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.5 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 1.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.4 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.3 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.0 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 45 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 5.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 5.2 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 4.3 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 3.1 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 2.9 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 2.9 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 2.7 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 2.7 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 2.5 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 2.3 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.1 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.0 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 2.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.9 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.9 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.6 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 1.5 | REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.1 | 1.4 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.0 | 1.4 | REACTOME_MUSCLE_CONTRACTION | Genes involved in Muscle contraction |
