Motif ID: KLF14_SP8

Z-value: 1.003

Transcription factors associated with KLF14_SP8:

Gene SymbolEntrez IDGene Name
KLF14 ENSG00000174595.4 KLF14
SP8 ENSG00000164651.12 SP8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SP8hg19_v2_chr7_-_20826504_20826526-0.396.2e-02Click!
KLF14hg19_v2_chr7_-_130418888_130418888-0.193.7e-01Click!


Activity profile for motif KLF14_SP8.

activity profile for motif KLF14_SP8


Sorted Z-values histogram for motif KLF14_SP8

Sorted Z-values for motif KLF14_SP8



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF14_SP8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_24734880 3.507 ENST00000382095.4
 SPATA13
spermatogenesis associated 13
chr11_+_73358594 3.435 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
 PLEKHB1


pleckstrin homology domain containing, family B (evectins) member 1


chr7_-_73184588 3.426 ENST00000395145.2
 CLDN3
claudin 3
chr12_-_25348007 3.231 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr19_-_55672037 3.048 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr13_+_24153488 2.852 ENST00000382258.4
ENST00000382263.3
 TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr9_-_124976185 2.583 ENST00000464484.2
 LHX6
LIM homeobox 6
chr6_+_43612750 2.578 ENST00000372165.4
ENST00000372163.4
 RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr9_-_124976154 2.509 ENST00000482062.1
 LHX6
LIM homeobox 6
chr5_-_149792295 2.473 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
 CD74



CD74 molecule, major histocompatibility complex, class II invariant chain



chr20_-_3154162 2.430 ENST00000360342.3
 LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr3_-_197686847 2.424 ENST00000265239.6
 IQCG
IQ motif containing G
chr16_+_84178874 2.326 ENST00000378553.5
 DNAAF1
dynein, axonemal, assembly factor 1
chr13_+_24734844 2.204 ENST00000382108.3
 SPATA13
spermatogenesis associated 13
chr1_-_45956800 2.015 ENST00000538496.1
 TESK2
testis-specific kinase 2
chr15_+_82555125 1.996 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
 FAM154B



family with sequence similarity 154, member B



chr9_+_124922171 1.926 ENST00000373764.3
ENST00000536616.1
 MORN5

MORN repeat containing 5

chr5_-_137368708 1.896 ENST00000033079.3
 FAM13B
family with sequence similarity 13, member B
chr6_-_31697563 1.829 ENST00000375789.2
ENST00000416410.1
 DDAH2

dimethylarginine dimethylaminohydrolase 2

chr6_-_10838736 1.827 ENST00000536370.1
ENST00000474039.1
 MAK

male germ cell-associated kinase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 440 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.1 GO:0044458 motile cilium assembly(GO:0044458)
0.4 5.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 5.2 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 4.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 4.8 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.4 3.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.4 3.5 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 3.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 3.2 GO:0007602 phototransduction(GO:0007602)
0.3 2.9 GO:0007288 sperm axoneme assembly(GO:0007288)
0.2 2.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.6 2.3 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.4 2.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 2.1 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 2.1 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.4 2.0 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 1.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.4 1.8 GO:1901090 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.4 1.7 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.4 1.7 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 6.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 4.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.1 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 3.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.8 3.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 3.1 GO:0005814 centriole(GO:0005814)
0.4 2.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 2.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.3 2.4 GO:0002177 manchette(GO:0002177)
0.5 2.3 GO:0005879 axonemal microtubule(GO:0005879)
0.0 2.3 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 2.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.5 2.0 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 2.0 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 2.0 GO:0034451 centriolar satellite(GO:0034451)
0.2 1.8 GO:0097255 R2TP complex(GO:0097255)
0.0 1.8 GO:0000786 nucleosome(GO:0000786)
0.1 1.7 GO:0001520 outer dense fiber(GO:0001520)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 4.8 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.6 3.9 GO:0016403 dimethylargininase activity(GO:0016403)
0.2 3.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 3.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 3.2 GO:0032027 myosin light chain binding(GO:0032027)
0.1 2.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 2.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 2.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 2.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.4 2.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 2.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1 2.0 GO:0070840 dynein complex binding(GO:0070840)
0.3 1.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.6 1.7 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.3 1.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 1.7 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.7 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.7 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 3.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 2.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.1 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.9 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.6 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.0 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.9 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 1.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.8 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.8 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.7 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.3 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 1.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis