Motif ID: KLF15

Z-value: 0.537


Transcription factors associated with KLF15:

Gene SymbolEntrez IDGene Name
KLF15 ENSG00000163884.3 KLF15

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF15hg19_v2_chr3_-_126076264_1260763050.174.2e-01Click!


Activity profile for motif KLF15.

activity profile for motif KLF15


Sorted Z-values histogram for motif KLF15

Sorted Z-values for motif KLF15



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_94285637 0.942 ENST00000482108.1
ENST00000488574.1
 PEG10

paternally expressed 10

chr6_-_29595779 0.876 ENST00000355973.3
ENST00000377012.4
 GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr1_-_47407097 0.777 ENST00000457840.2
 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr11_+_1874200 0.758 ENST00000311604.3
 LSP1
lymphocyte-specific protein 1
chr22_-_50970506 0.752 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chr8_+_81397876 0.673 ENST00000430430.1
 ZBTB10
zinc finger and BTB domain containing 10
chr7_-_99869799 0.659 ENST00000436886.2
 GATS
GATS, stromal antigen 3 opposite strand
chr3_-_12200851 0.656 ENST00000287814.4
 TIMP4
TIMP metallopeptidase inhibitor 4
chr7_-_94285511 0.653 ENST00000265735.7
 SGCE
sarcoglycan, epsilon
chr14_-_65439132 0.639 ENST00000533601.2
 RAB15
RAB15, member RAS oncogene family
chr7_-_94285402 0.619 ENST00000428696.2
ENST00000445866.2
 SGCE

sarcoglycan, epsilon

chr18_-_74207146 0.617 ENST00000443185.2
 ZNF516
zinc finger protein 516
chr6_-_80247105 0.583 ENST00000369846.4
 LCA5
Leber congenital amaurosis 5
chr4_+_74702214 0.578 ENST00000226317.5
ENST00000515050.1
 CXCL6

chemokine (C-X-C motif) ligand 6

chr18_-_45935663 0.570 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
 ZBTB7C







zinc finger and BTB domain containing 7C







chr7_-_94285472 0.565 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
 SGCE


sarcoglycan, epsilon


chr6_-_80247140 0.563 ENST00000392959.1
ENST00000467898.3
 LCA5

Leber congenital amaurosis 5

chr7_-_154863264 0.537 ENST00000395731.2
ENST00000543018.1
 HTR5A-AS1

HTR5A antisense RNA 1

chr5_+_17217669 0.501 ENST00000322611.3
 BASP1
brain abundant, membrane attached signal protein 1
chr17_-_4545170 0.495 ENST00000576394.1
ENST00000574640.1
 ALOX15

arachidonate 15-lipoxygenase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:1903307 positive regulation of regulated secretory pathway(GO:1903307)
0.3 1.0 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.9 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.7 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.6 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.6 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 0.5 GO:2001301 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.2 0.5 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.1 0.5 GO:2001076 regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.5 GO:0002021 response to dietary excess(GO:0002021)
0.1 0.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0035640 exploration behavior(GO:0035640)
0.1 0.3 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.3 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 0.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.8 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.3 GO:0031213 RSF complex(GO:0031213)
0.0 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.0 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.2 0.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.2 0.5 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.5 GO:0045545 syndecan binding(GO:0045545)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.4 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.3 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.3 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.7 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels