Motif ID: KLF16_SP2

Z-value: 2.086

Transcription factors associated with KLF16_SP2:

Gene SymbolEntrez IDGene Name
KLF16 ENSG00000129911.4 KLF16
SP2 ENSG00000167182.11 SP2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF16hg19_v2_chr19_-_1863567_1863586-0.481.6e-02Click!
SP2hg19_v2_chr17_+_45973516_459736180.058.2e-01Click!


Activity profile for motif KLF16_SP2.

activity profile for motif KLF16_SP2


Sorted Z-values histogram for motif KLF16_SP2

Sorted Z-values for motif KLF16_SP2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF16_SP2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_158380371 13.424 ENST00000389418.4
ENST00000389416.4
 PTPRN2

protein tyrosine phosphatase, receptor type, N polypeptide 2

chr21_-_43916433 11.830 ENST00000291536.3
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr7_-_158380465 11.307 ENST00000389413.3
ENST00000409483.1
 PTPRN2

protein tyrosine phosphatase, receptor type, N polypeptide 2

chr16_-_67427389 10.572 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
 TPPP3


tubulin polymerization-promoting protein family member 3


chr11_+_2466218 10.371 ENST00000155840.5
 KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr16_+_67465016 9.472 ENST00000326152.5
 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr19_-_55672037 9.310 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr7_-_123174610 9.240 ENST00000324698.6
ENST00000434450.1
 IQUB

IQ motif and ubiquitin domain containing

chr19_-_55677999 8.748 ENST00000532817.1
ENST00000527223.2
ENST00000391720.4
 DNAAF3


dynein, axonemal, assembly factor 3


chr21_-_43916296 8.685 ENST00000398352.3
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr6_+_43612750 8.681 ENST00000372165.4
ENST00000372163.4
 RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr19_+_55795493 8.671 ENST00000309383.1
 BRSK1
BR serine/threonine kinase 1
chr11_+_111385497 8.500 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
 C11orf88


chromosome 11 open reading frame 88


chr19_+_4639514 8.495 ENST00000327473.4
 TNFAIP8L1
tumor necrosis factor, alpha-induced protein 8-like 1
chr22_-_50970506 8.323 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chrX_+_152338301 8.200 ENST00000453825.2
 PNMA6A
paraneoplastic Ma antigen family member 6A
chr3_-_19988462 8.156 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr9_+_34458771 7.914 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr17_+_55333876 7.818 ENST00000284073.2
 MSI2
musashi RNA-binding protein 2
chr20_-_3154162 7.812 ENST00000360342.3
 LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,258 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 68.8 GO:0044458 motile cilium assembly(GO:0044458)
1.1 51.9 GO:0035082 axoneme assembly(GO:0035082)
1.7 18.8 GO:0043985 histone H4-R3 methylation(GO:0043985)
3.7 18.3 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.4 18.1 GO:0042073 intraciliary transport(GO:0042073)
0.2 17.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 16.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.3 15.7 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.8 14.3 GO:0070986 left/right axis specification(GO:0070986)
1.0 12.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.8 12.1 GO:0060452 positive regulation of cardiac muscle contraction(GO:0060452)
0.8 12.0 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
1.2 11.9 GO:0070269 pyroptosis(GO:0070269)
0.3 11.8 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.2 10.7 GO:0014047 glutamate secretion(GO:0014047)
0.1 10.7 GO:0007224 smoothened signaling pathway(GO:0007224)
0.8 10.5 GO:0060180 female mating behavior(GO:0060180)
0.4 10.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
1.1 10.3 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.3 10.1 GO:0043968 histone H2A acetylation(GO:0043968)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 405 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 43.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
1.1 31.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 28.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
1.8 25.4 GO:0001520 outer dense fiber(GO:0001520)
0.7 21.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.2 21.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 19.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 16.8 GO:0036064 ciliary basal body(GO:0036064)
0.8 15.8 GO:0036038 MKS complex(GO:0036038)
0.1 15.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 14.8 GO:0016604 nuclear body(GO:0016604)
0.7 14.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.2 11.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 11.8 GO:0005814 centriole(GO:0005814)
2.9 11.6 GO:0097224 sperm connecting piece(GO:0097224)
1.9 11.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.4 10.6 GO:0016580 Sin3 complex(GO:0016580)
1.4 9.9 GO:0002177 manchette(GO:0002177)
0.8 9.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 9.1 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 683 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 66.0 GO:0003677 DNA binding(GO:0003677)
1.0 29.1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 27.6 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.9 20.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 16.9 GO:0042393 histone binding(GO:0042393)
0.2 16.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.9 14.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.4 14.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 14.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.2 14.3 GO:0033558 protein deacetylase activity(GO:0033558)
0.3 14.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.9 13.5 GO:0035497 cAMP response element binding(GO:0035497)
1.3 13.0 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.7 12.8 GO:0003680 AT DNA binding(GO:0003680)
0.9 12.3 GO:0032027 myosin light chain binding(GO:0032027)
1.0 12.2 GO:0019826 oxygen sensor activity(GO:0019826)
1.3 11.7 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
2.7 10.9 GO:1904408 dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
0.4 10.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
1.8 10.7 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 24.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 18.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 15.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.3 15.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 15.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 12.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 10.4 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 10.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 9.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 9.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 8.4 PID_MYC_PATHWAY C-MYC pathway
0.1 7.8 PID_BMP_PATHWAY BMP receptor signaling
0.1 7.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 7.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 6.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 6.2 PID_ALK2_PATHWAY ALK2 signaling events
0.1 5.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 5.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 3.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 34.4 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.2 22.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 21.9 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.2 14.9 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.3 14.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 13.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 13.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.5 12.5 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.2 12.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 11.8 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.2 11.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 11.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.4 10.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 10.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 9.0 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 8.1 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 8.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 6.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 6.3 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 6.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres