Motif ID: KLF3
Z-value: 0.889
Transcription factors associated with KLF3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| KLF3 | ENSG00000109787.8 | KLF3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF3 | hg19_v2_chr4_+_38665810_38665827 | 0.16 | 4.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.3 | 1.6 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.3 | 1.0 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.2 | 1.3 | GO:1901569 | leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569) |
| 0.2 | 0.6 | GO:0014876 | response to injury involved in regulation of muscle adaptation(GO:0014876) |
| 0.2 | 0.5 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.1 | 0.4 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
| 0.1 | 0.4 | GO:1904328 | regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764) |
| 0.1 | 0.9 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.1 | 2.1 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
| 0.1 | 0.5 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.1 | 0.3 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.1 | 2.6 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.1 | 0.3 | GO:0006788 | heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806) negative regulation of mast cell cytokine production(GO:0032764) |
| 0.1 | 0.4 | GO:0035948 | N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 0.1 | 1.1 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.1 | 0.6 | GO:0044034 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) negative regulation of histone H4-K16 acetylation(GO:2000619) |
| 0.1 | 0.9 | GO:0033578 | protein glycosylation in Golgi(GO:0033578) |
| 0.1 | 0.7 | GO:0045079 | negative regulation of chemokine biosynthetic process(GO:0045079) |
| 0.1 | 0.3 | GO:1905246 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.1 | 0.9 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 0.1 | 0.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.3 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.1 | 0.3 | GO:1902490 | regulation of sperm capacitation(GO:1902490) |
| 0.1 | 0.3 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 0.1 | 0.4 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 0.1 | 0.6 | GO:1902019 | regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019) |
| 0.1 | 0.3 | GO:0032849 | positive regulation of cellular pH reduction(GO:0032849) |
| 0.1 | 0.1 | GO:0002125 | maternal aggressive behavior(GO:0002125) |
| 0.1 | 0.4 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 0.1 | 0.3 | GO:0070945 | neutrophil mediated killing of gram-negative bacterium(GO:0070945) |
| 0.1 | 1.3 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 1.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 0.4 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.1 | 0.6 | GO:0051106 | positive regulation of DNA ligation(GO:0051106) |
| 0.1 | 0.4 | GO:0019556 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.1 | 0.3 | GO:0071400 | cellular response to oleic acid(GO:0071400) |
| 0.1 | 1.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.1 | 0.5 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 0.7 | GO:0030046 | parallel actin filament bundle assembly(GO:0030046) |
| 0.1 | 0.2 | GO:0044691 | tooth eruption(GO:0044691) |
| 0.1 | 0.2 | GO:0090034 | regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035) |
| 0.1 | 0.3 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.1 | 0.5 | GO:0071104 | response to interleukin-9(GO:0071104) |
| 0.1 | 0.3 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.1 | 0.4 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.1 | 0.2 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.1 | 0.8 | GO:0035810 | positive regulation of urine volume(GO:0035810) |
| 0.0 | 0.2 | GO:1903788 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 0.0 | 0.2 | GO:0097021 | Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.0 | 0.3 | GO:0097327 | response to antineoplastic agent(GO:0097327) |
| 0.0 | 1.0 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.0 | 0.3 | GO:2000561 | CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) |
| 0.0 | 0.1 | GO:1990737 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.0 | 0.3 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.0 | 0.1 | GO:0032223 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.0 | 0.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 0.2 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.0 | 0.2 | GO:0002215 | defense response to nematode(GO:0002215) |
| 0.0 | 0.4 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 0.3 | GO:0002933 | lipid hydroxylation(GO:0002933) |
| 0.0 | 0.2 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.0 | 0.2 | GO:0007402 | ganglion mother cell fate determination(GO:0007402) |
| 0.0 | 0.1 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
| 0.0 | 0.2 | GO:1904995 | negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995) |
| 0.0 | 0.2 | GO:0015798 | myo-inositol transport(GO:0015798) |
| 0.0 | 0.5 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 0.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.2 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.2 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
| 0.0 | 0.3 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.2 | GO:0043366 | beta selection(GO:0043366) |
| 0.0 | 0.1 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.0 | 0.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.0 | 0.2 | GO:0090116 | C-5 methylation of cytosine(GO:0090116) |
| 0.0 | 0.4 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 0.1 | GO:0042335 | cuticle development(GO:0042335) |
| 0.0 | 0.1 | GO:2001178 | mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178) |
| 0.0 | 0.1 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
| 0.0 | 0.1 | GO:0010847 | regulation of chromatin assembly(GO:0010847) negative regulation of protein import into nucleus, translocation(GO:0033159) protein auto-ADP-ribosylation(GO:0070213) |
| 0.0 | 0.6 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.0 | 0.1 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.0 | 0.1 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.0 | 0.8 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.0 | 0.2 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.0 | 0.3 | GO:0006366 | transcription from RNA polymerase II promoter(GO:0006366) |
| 0.0 | 0.5 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.0 | 0.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.1 | GO:0014040 | positive regulation of Schwann cell differentiation(GO:0014040) |
| 0.0 | 1.3 | GO:0010039 | response to iron ion(GO:0010039) |
| 0.0 | 0.2 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.0 | 0.2 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.3 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.0 | 0.3 | GO:0045023 | G0 to G1 transition(GO:0045023) |
| 0.0 | 0.3 | GO:0021694 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.0 | 0.1 | GO:0035425 | autocrine signaling(GO:0035425) |
| 0.0 | 0.2 | GO:0045054 | constitutive secretory pathway(GO:0045054) |
| 0.0 | 0.2 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.0 | 0.1 | GO:0061010 | negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010) |
| 0.0 | 0.4 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.3 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 0.2 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.0 | 0.2 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.0 | 0.3 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.0 | 0.1 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.0 | 0.3 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.1 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.0 | 0.6 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 0.1 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.0 | 0.3 | GO:0010623 | programmed cell death involved in cell development(GO:0010623) |
| 0.0 | 0.1 | GO:0001927 | exocyst assembly(GO:0001927) |
| 0.0 | 0.1 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.0 | 0.1 | GO:0046618 | drug export(GO:0046618) |
| 0.0 | 0.1 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.0 | 0.2 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 1.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.1 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.0 | 0.1 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.0 | 0.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.0 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
| 0.0 | 0.2 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.0 | 0.1 | GO:0015860 | purine nucleoside transmembrane transport(GO:0015860) |
| 0.0 | 0.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.1 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 0.4 | GO:0010226 | response to lithium ion(GO:0010226) |
| 0.0 | 0.0 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.0 | 0.1 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.0 | 0.9 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 0.2 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.1 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.0 | 0.2 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.0 | 0.0 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 0.0 | 0.1 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.0 | 0.5 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 0.0 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) |
| 0.0 | 0.3 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.0 | 0.2 | GO:0006833 | water transport(GO:0006833) |
| 0.0 | 0.3 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 1.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.2 | GO:0003334 | keratinocyte development(GO:0003334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.2 | 2.6 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.1 | 0.6 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.1 | 0.3 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 1.0 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 0.3 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.1 | 0.6 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.1 | 1.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.4 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 0.3 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 1.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.4 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 3.8 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.1 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.0 | 0.1 | GO:0071159 | NF-kappaB complex(GO:0071159) |
| 0.0 | 0.4 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.1 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 0.1 | GO:1990923 | PET complex(GO:1990923) |
| 0.0 | 0.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.1 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 0.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.4 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 1.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.3 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 0.2 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 0.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.3 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.3 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.0 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.0 | 0.2 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 0.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 1.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0052870 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.3 | 1.8 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.2 | 2.6 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.2 | 1.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 1.8 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.1 | 0.8 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 0.3 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 0.4 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.1 | 0.6 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.1 | 0.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 0.3 | GO:0032440 | 2-alkenal reductase [NAD(P)] activity(GO:0032440) |
| 0.1 | 0.3 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.1 | 0.3 | GO:0004087 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.1 | 0.4 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.1 | 0.3 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.1 | 0.9 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.1 | 1.5 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 0.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 0.2 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.1 | 0.6 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.1 | 0.2 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 0.3 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.1 | 0.6 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 0.4 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.1 | 1.1 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 0.7 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.1 | 0.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 0.4 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.1 | 0.5 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.0 | 1.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.6 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.0 | 0.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 0.5 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 1.0 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 1.4 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.9 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.2 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.0 | 0.2 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.0 | 0.3 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.4 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.0 | 0.3 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.2 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
| 0.0 | 0.1 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.0 | 0.6 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 1.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.4 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.8 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.6 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 0.5 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.0 | 0.3 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.0 | 0.2 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.0 | 0.2 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.0 | 0.6 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.0 | 0.3 | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144) |
| 0.0 | 0.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.2 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.0 | 0.2 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 0.0 | 0.1 | GO:0005415 | nucleoside:sodium symporter activity(GO:0005415) |
| 0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.0 | 0.5 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.0 | 1.0 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.0 | 0.1 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.1 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 0.0 | 0.1 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.0 | 0.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 0.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.1 | GO:0019863 | IgE binding(GO:0019863) |
| 0.0 | 0.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.1 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.0 | 0.1 | GO:0051022 | GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.0 | 0.2 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 0.1 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.0 | 0.1 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.0 | 0.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.1 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.0 | 0.5 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 0.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.1 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.0 | 0.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 0.1 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.0 | 0.1 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.0 | 0.0 | GO:0016499 | orexin receptor activity(GO:0016499) |
| 0.0 | 0.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.1 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 0.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.1 | GO:0016805 | dipeptidase activity(GO:0016805) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.4 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.8 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.1 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.8 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.2 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.2 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
| 0.0 | 1.1 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.3 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.0 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 1.4 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 0.9 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.8 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 1.8 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 0.4 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.5 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.8 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.7 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PE | Genes involved in Acyl chain remodelling of PE |
| 0.0 | 1.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.7 | REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.3 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 1.0 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.4 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.3 | REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.3 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.2 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.3 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.0 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.2 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
