Motif ID: KLF6
Z-value: 1.033
Transcription factors associated with KLF6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
KLF6 | ENSG00000067082.10 | KLF6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
KLF6 | hg19_v2_chr10_-_3827417_3827473 | -0.48 | 1.7e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.0 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
0.5 | 2.3 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) seminal vesicle development(GO:0061107) |
0.4 | 1.6 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
0.3 | 2.1 | GO:0097338 | response to clozapine(GO:0097338) |
0.3 | 1.0 | GO:0009726 | detection of endogenous stimulus(GO:0009726) |
0.2 | 1.0 | GO:0000255 | allantoin metabolic process(GO:0000255) |
0.2 | 4.1 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
0.2 | 1.6 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
0.2 | 1.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.2 | 0.7 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
0.2 | 1.2 | GO:0009450 | acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450) |
0.2 | 0.5 | GO:0071529 | cementum mineralization(GO:0071529) |
0.2 | 7.2 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
0.2 | 1.6 | GO:0097688 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
0.2 | 0.6 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
0.1 | 0.4 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
0.1 | 0.6 | GO:0071934 | thiamine transmembrane transport(GO:0071934) |
0.1 | 0.7 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) metanephric renal vesicle formation(GO:0072093) |
0.1 | 0.4 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
0.1 | 0.4 | GO:0032240 | mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832) |
0.1 | 1.0 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
0.1 | 0.5 | GO:0043335 | protein unfolding(GO:0043335) |
0.1 | 0.7 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
0.1 | 0.6 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
0.1 | 0.9 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
0.1 | 0.5 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
0.1 | 0.5 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.1 | 0.4 | GO:0021553 | olfactory nerve development(GO:0021553) |
0.1 | 0.8 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
0.1 | 0.3 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
0.1 | 0.9 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
0.1 | 1.0 | GO:0045054 | constitutive secretory pathway(GO:0045054) |
0.1 | 0.5 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
0.1 | 2.9 | GO:0016578 | histone deubiquitination(GO:0016578) |
0.1 | 1.7 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
0.1 | 0.3 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
0.1 | 0.3 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
0.1 | 1.4 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.1 | 0.4 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
0.1 | 0.3 | GO:1903281 | positive regulation of calcium:sodium antiporter activity(GO:1903281) |
0.1 | 0.5 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
0.1 | 0.6 | GO:0071500 | cellular response to nitrosative stress(GO:0071500) |
0.1 | 3.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.1 | 1.5 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
0.1 | 0.5 | GO:0033183 | negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) |
0.1 | 0.9 | GO:1902659 | regulation of glucose mediated signaling pathway(GO:1902659) |
0.1 | 1.2 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
0.1 | 0.4 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
0.1 | 0.3 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) histone H3-K36 dimethylation(GO:0097676) |
0.1 | 0.9 | GO:0032782 | bile acid secretion(GO:0032782) |
0.1 | 0.6 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
0.1 | 0.6 | GO:0048105 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) |
0.1 | 0.5 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.1 | 0.1 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
0.1 | 0.8 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
0.1 | 0.7 | GO:0042996 | regulation of Golgi to plasma membrane protein transport(GO:0042996) |
0.1 | 0.3 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
0.1 | 0.3 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
0.1 | 0.4 | GO:0060431 | primary lung bud formation(GO:0060431) |
0.1 | 0.3 | GO:0090034 | regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035) |
0.1 | 0.2 | GO:1902824 | positive regulation of late endosome to lysosome transport(GO:1902824) |
0.1 | 0.1 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.1 | 0.2 | GO:0090283 | regulation of protein glycosylation in Golgi(GO:0090283) |
0.1 | 0.2 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
0.1 | 0.6 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
0.1 | 1.0 | GO:0021514 | ventral spinal cord interneuron differentiation(GO:0021514) |
0.1 | 0.2 | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758) |
0.1 | 0.6 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
0.1 | 0.6 | GO:0042048 | olfactory behavior(GO:0042048) |
0.1 | 0.2 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
0.1 | 0.9 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
0.1 | 0.1 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
0.1 | 0.4 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.1 | 0.1 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
0.1 | 0.3 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
0.1 | 0.5 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.0 | 0.2 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
0.0 | 0.3 | GO:0009052 | D-ribose metabolic process(GO:0006014) pentose-phosphate shunt, non-oxidative branch(GO:0009052) |
0.0 | 0.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
0.0 | 0.1 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
0.0 | 0.2 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
0.0 | 0.6 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
0.0 | 0.6 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
0.0 | 0.4 | GO:0070459 | prolactin secretion(GO:0070459) |
0.0 | 0.5 | GO:0070070 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
0.0 | 0.1 | GO:0060988 | lipid tube assembly(GO:0060988) |
0.0 | 0.3 | GO:0070294 | renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294) |
0.0 | 0.5 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.0 | 0.4 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
0.0 | 0.2 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
0.0 | 0.5 | GO:0060033 | anatomical structure regression(GO:0060033) |
0.0 | 0.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
0.0 | 0.6 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
0.0 | 0.2 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
0.0 | 0.2 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
0.0 | 0.2 | GO:0060157 | urea transport(GO:0015840) urinary bladder development(GO:0060157) |
0.0 | 1.4 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
0.0 | 0.6 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
0.0 | 0.1 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
0.0 | 0.5 | GO:0006527 | arginine catabolic process(GO:0006527) |
0.0 | 0.6 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.0 | 0.2 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.0 | 0.0 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
0.0 | 0.2 | GO:0015870 | acetylcholine transport(GO:0015870) |
0.0 | 0.2 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.0 | 0.2 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
0.0 | 0.1 | GO:0003150 | muscular septum morphogenesis(GO:0003150) |
0.0 | 2.1 | GO:0043966 | histone H3 acetylation(GO:0043966) |
0.0 | 0.2 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
0.0 | 0.2 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
0.0 | 0.1 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
0.0 | 0.1 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
0.0 | 0.6 | GO:0038092 | nodal signaling pathway(GO:0038092) |
0.0 | 0.1 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
0.0 | 0.2 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
0.0 | 0.3 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
0.0 | 0.3 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.0 | 0.2 | GO:1905247 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247) |
0.0 | 0.5 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
0.0 | 0.4 | GO:0007625 | grooming behavior(GO:0007625) |
0.0 | 0.1 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
0.0 | 0.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.0 | 0.4 | GO:0006020 | inositol metabolic process(GO:0006020) |
0.0 | 0.4 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
0.0 | 0.2 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
0.0 | 0.1 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
0.0 | 1.3 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
0.0 | 0.4 | GO:0048149 | behavioral response to ethanol(GO:0048149) |
0.0 | 0.2 | GO:0010694 | transcription from mitochondrial promoter(GO:0006390) positive regulation of alkaline phosphatase activity(GO:0010694) |
0.0 | 0.2 | GO:0002115 | store-operated calcium entry(GO:0002115) |
0.0 | 0.1 | GO:0090166 | Golgi disassembly(GO:0090166) |
0.0 | 0.4 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
0.0 | 0.1 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
0.0 | 0.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
0.0 | 0.0 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
0.0 | 0.2 | GO:0046626 | regulation of insulin receptor signaling pathway(GO:0046626) |
0.0 | 0.3 | GO:0033197 | response to vitamin E(GO:0033197) |
0.0 | 0.2 | GO:0072718 | response to cisplatin(GO:0072718) |
0.0 | 0.3 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
0.0 | 0.1 | GO:0072233 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
0.0 | 0.1 | GO:1903301 | regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301) |
0.0 | 0.2 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
0.0 | 0.4 | GO:0031167 | rRNA methylation(GO:0031167) |
0.0 | 0.1 | GO:1902214 | regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
0.0 | 0.3 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
0.0 | 0.2 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
0.0 | 0.1 | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052) |
0.0 | 0.5 | GO:0009081 | branched-chain amino acid metabolic process(GO:0009081) |
0.0 | 0.2 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.0 | 0.3 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
0.0 | 0.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
0.0 | 0.2 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
0.0 | 1.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
0.0 | 0.1 | GO:0034244 | negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
0.0 | 0.2 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
0.0 | 0.4 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
0.0 | 0.4 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
0.0 | 0.1 | GO:0042756 | drinking behavior(GO:0042756) |
0.0 | 0.3 | GO:0031507 | heterochromatin assembly(GO:0031507) |
0.0 | 0.1 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
0.0 | 0.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
0.0 | 0.1 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
0.0 | 1.0 | GO:0010830 | regulation of myotube differentiation(GO:0010830) |
0.0 | 0.1 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.0 | 0.2 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
0.0 | 0.1 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
0.0 | 0.6 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
0.0 | 0.1 | GO:0055072 | iron ion homeostasis(GO:0055072) |
0.0 | 0.3 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
0.0 | 0.1 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
0.0 | 0.2 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
0.0 | 0.6 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
0.0 | 0.0 | GO:0006424 | glutamyl-tRNA aminoacylation(GO:0006424) |
0.0 | 0.2 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
0.0 | 0.1 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
0.0 | 0.2 | GO:0010764 | negative regulation of fibroblast migration(GO:0010764) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 3.0 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
0.3 | 1.0 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
0.2 | 1.2 | GO:1990769 | proximal neuron projection(GO:1990769) |
0.2 | 1.8 | GO:0044294 | dendritic growth cone(GO:0044294) |
0.2 | 0.6 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
0.2 | 0.8 | GO:0005667 | transcription factor complex(GO:0005667) |
0.2 | 3.0 | GO:0000124 | SAGA complex(GO:0000124) |
0.2 | 1.9 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
0.2 | 0.6 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
0.1 | 1.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
0.1 | 0.6 | GO:0060187 | cell pole(GO:0060187) |
0.1 | 1.7 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.1 | 1.6 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
0.1 | 0.5 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
0.1 | 0.5 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.1 | 0.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
0.1 | 2.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.1 | 1.2 | GO:0097433 | dense body(GO:0097433) |
0.1 | 0.6 | GO:1990393 | 3M complex(GO:1990393) |
0.1 | 0.9 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
0.1 | 1.0 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.1 | 2.0 | GO:0097386 | glial cell projection(GO:0097386) |
0.1 | 0.9 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.1 | 0.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.1 | 0.3 | GO:0035061 | interchromatin granule(GO:0035061) |
0.1 | 0.4 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
0.1 | 0.5 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
0.1 | 0.5 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
0.1 | 0.7 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
0.1 | 0.4 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
0.1 | 0.4 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
0.1 | 0.5 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
0.1 | 1.3 | GO:0042641 | actomyosin(GO:0042641) |
0.1 | 0.5 | GO:0001739 | sex chromatin(GO:0001739) |
0.0 | 0.9 | GO:0042405 | nuclear inclusion body(GO:0042405) |
0.0 | 1.0 | GO:0097225 | sperm midpiece(GO:0097225) |
0.0 | 0.4 | GO:0072487 | MSL complex(GO:0072487) |
0.0 | 0.3 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
0.0 | 0.3 | GO:1990130 | Iml1 complex(GO:1990130) |
0.0 | 0.3 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
0.0 | 1.3 | GO:0016580 | Sin3 complex(GO:0016580) |
0.0 | 0.7 | GO:0016461 | unconventional myosin complex(GO:0016461) |
0.0 | 0.2 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
0.0 | 0.1 | GO:0032044 | DSIF complex(GO:0032044) |
0.0 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
0.0 | 0.5 | GO:0016328 | lateral plasma membrane(GO:0016328) |
0.0 | 1.0 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
0.0 | 0.5 | GO:0071439 | clathrin complex(GO:0071439) |
0.0 | 0.5 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.2 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
0.0 | 0.3 | GO:0005677 | chromatin silencing complex(GO:0005677) |
0.0 | 0.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
0.0 | 0.2 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.0 | 0.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
0.0 | 0.1 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
0.0 | 0.2 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
0.0 | 0.2 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.0 | 0.2 | GO:0035859 | Seh1-associated complex(GO:0035859) |
0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.0 | 0.0 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 2.0 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
0.0 | 0.5 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.2 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
0.0 | 0.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 0.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 0.1 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.1 | GO:0016011 | dystroglycan complex(GO:0016011) |
0.0 | 0.7 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 0.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.0 | 0.2 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
0.0 | 0.2 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.0 | 0.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.0 | 0.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 3.5 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
0.8 | 3.0 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
0.5 | 1.6 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.5 | 2.0 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
0.3 | 0.9 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
0.2 | 0.6 | GO:0015403 | thiamine uptake transmembrane transporter activity(GO:0015403) |
0.2 | 0.5 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
0.2 | 1.8 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.1 | 0.5 | GO:0043398 | HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763) |
0.1 | 0.9 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
0.1 | 1.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.1 | 2.1 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.1 | 0.4 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
0.1 | 0.4 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
0.1 | 0.2 | GO:0004019 | adenylosuccinate synthase activity(GO:0004019) |
0.1 | 0.5 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
0.1 | 0.6 | GO:0043559 | insulin binding(GO:0043559) |
0.1 | 0.4 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
0.1 | 1.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.1 | 0.4 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
0.1 | 0.5 | GO:0016403 | dimethylargininase activity(GO:0016403) |
0.1 | 0.5 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.1 | 0.3 | GO:1990460 | leptin receptor binding(GO:1990460) |
0.1 | 0.3 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
0.1 | 0.2 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
0.1 | 0.6 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
0.1 | 0.8 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
0.1 | 0.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.0 | 0.2 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
0.0 | 0.4 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.0 | 0.4 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
0.0 | 1.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.0 | 0.5 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 3.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 1.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 0.6 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
0.0 | 0.3 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.0 | 0.5 | GO:0038132 | neuregulin binding(GO:0038132) |
0.0 | 0.2 | GO:1901375 | acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375) |
0.0 | 0.3 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
0.0 | 0.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.0 | 0.4 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.0 | 1.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 0.3 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
0.0 | 0.5 | GO:0019903 | protein phosphatase binding(GO:0019903) |
0.0 | 0.7 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
0.0 | 0.5 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
0.0 | 0.8 | GO:0035173 | histone kinase activity(GO:0035173) |
0.0 | 1.0 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
0.0 | 0.2 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
0.0 | 0.9 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.3 | GO:0071253 | connexin binding(GO:0071253) |
0.0 | 0.1 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
0.0 | 1.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.3 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 0.5 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
0.0 | 0.5 | GO:0009881 | photoreceptor activity(GO:0009881) |
0.0 | 0.2 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.0 | 0.3 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.0 | 0.8 | GO:0008143 | poly(A) binding(GO:0008143) |
0.0 | 0.3 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
0.0 | 0.1 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
0.0 | 0.2 | GO:0050816 | phosphothreonine binding(GO:0050816) |
0.0 | 0.6 | GO:0051117 | ATPase binding(GO:0051117) |
0.0 | 2.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 0.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.0 | 1.0 | GO:0017046 | peptide hormone binding(GO:0017046) |
0.0 | 0.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.1 | GO:0061665 | SUMO ligase activity(GO:0061665) |
0.0 | 0.4 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
0.0 | 0.1 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
0.0 | 0.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.0 | 0.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.3 | GO:0003680 | AT DNA binding(GO:0003680) |
0.0 | 0.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.7 | GO:0070840 | dynein complex binding(GO:0070840) |
0.0 | 0.4 | GO:0000339 | RNA cap binding(GO:0000339) |
0.0 | 0.4 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
0.0 | 0.4 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 0.5 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.0 | 0.3 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 1.3 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
0.0 | 0.1 | GO:0000832 | inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) inositol hexakisphosphate kinase activity(GO:0000828) inositol heptakisphosphate kinase activity(GO:0000829) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
0.0 | 0.1 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
0.0 | 2.1 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.0 | 0.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
0.0 | 0.2 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
0.0 | 0.5 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
0.0 | 0.0 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 0.2 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
0.0 | 6.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.0 | 0.3 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
0.0 | 0.3 | GO:0033613 | activating transcription factor binding(GO:0033613) |
0.0 | 1.2 | GO:0051287 | NAD binding(GO:0051287) |
0.0 | 0.1 | GO:0097677 | STAT family protein binding(GO:0097677) |
0.0 | 0.0 | GO:0033149 | FFAT motif binding(GO:0033149) |
0.0 | 0.1 | GO:0015288 | porin activity(GO:0015288) |
0.0 | 0.0 | GO:0031177 | acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177) |
0.0 | 0.1 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
0.0 | 0.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.0 | 0.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.0 | 0.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.3 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 0.0 | GO:0004818 | glutamate-tRNA ligase activity(GO:0004818) |
0.0 | 0.1 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.0 | 0.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.0 | 0.1 | GO:0048156 | tau protein binding(GO:0048156) |
0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.0 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.1 | 1.8 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
0.1 | 2.0 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 0.2 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
0.0 | 2.9 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 1.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 1.4 | PID_IFNG_PATHWAY | IFN-gamma pathway |
0.0 | 0.5 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 0.3 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
0.0 | 0.3 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
0.0 | 0.6 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.0 | 0.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
0.0 | 0.3 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.0 | 1.3 | PID_CDC42_PATHWAY | CDC42 signaling events |
0.0 | 0.9 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.0 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.1 | 2.1 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
0.1 | 0.2 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.0 | 1.2 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.0 | 0.5 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
0.0 | 1.0 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
0.0 | 1.1 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.0 | 1.7 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.0 | 0.6 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.0 | 0.7 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 0.1 | REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
0.0 | 0.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
0.0 | 0.2 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
0.0 | 0.8 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.0 | 0.4 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
0.0 | 0.8 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
0.0 | 1.5 | REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
0.0 | 3.3 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
0.0 | 0.5 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.0 | 0.5 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
0.0 | 1.2 | REACTOME_CIRCADIAN_CLOCK | Genes involved in Circadian Clock |
0.0 | 0.5 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
0.0 | 0.6 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.0 | 0.2 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
0.0 | 1.0 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 0.4 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
0.0 | 1.9 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |