Motif ID: KLF6

Z-value: 1.033


Transcription factors associated with KLF6:

Gene SymbolEntrez IDGene Name
KLF6 ENSG00000067082.10 KLF6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF6hg19_v2_chr10_-_3827417_3827473-0.481.7e-02Click!


Activity profile for motif KLF6.

activity profile for motif KLF6


Sorted Z-values histogram for motif KLF6

Sorted Z-values for motif KLF6



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_67465016 3.505 ENST00000326152.5
 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr6_-_29595779 3.027 ENST00000355973.3
ENST00000377012.4
 GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr13_+_35516390 2.583 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr6_+_19837592 2.326 ENST00000378700.3
 ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr17_-_42277203 2.278 ENST00000587097.1
 ATXN7L3
ataxin 7-like 3
chr7_+_106685079 2.110 ENST00000265717.4
 PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr16_+_69600209 1.951 ENST00000566899.1
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69599861 1.666 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr19_+_45504688 1.665 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
 RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr16_+_69599899 1.500 ENST00000567239.1
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69600058 1.282 ENST00000393742.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_+_24495067 1.249 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
 ALDH5A1


aldehyde dehydrogenase 5 family, member A1


chr8_-_110656995 1.239 ENST00000276646.9
ENST00000533065.1
 SYBU

syntabulin (syntaxin-interacting)

chr3_-_19988462 1.199 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr11_+_45907177 1.186 ENST00000241014.2
 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr3_-_113415441 1.180 ENST00000491165.1
ENST00000316407.4
 KIAA2018

KIAA2018

chr12_-_112450915 1.169 ENST00000437003.2
ENST00000552374.2
ENST00000550831.3
ENST00000354825.3
ENST00000549537.2
ENST00000355445.3
 TMEM116





transmembrane protein 116





chr9_-_37465396 1.117 ENST00000307750.4
 ZBTB5
zinc finger and BTB domain containing 5
chr1_+_151254738 1.049 ENST00000336715.6
ENST00000324048.5
ENST00000368879.2
 ZNF687


zinc finger protein 687


chr17_-_7145475 1.047 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
 GABARAP


GABA(A) receptor-associated protein



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 4.1 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.1 3.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 2.9 GO:0016578 histone deubiquitination(GO:0016578)
0.5 2.3 GO:0060741 prostate gland stromal morphogenesis(GO:0060741) seminal vesicle development(GO:0061107)
0.3 2.1 GO:0097338 response to clozapine(GO:0097338)
0.0 2.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.5 2.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.2 1.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.4 1.6 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 1.6 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.2 1.6 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 1.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 1.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 1.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 1.4 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 1.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 1.2 GO:0009450 acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.1 1.2 GO:0048681 negative regulation of axon regeneration(GO:0048681)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 3.0 GO:0000124 SAGA complex(GO:0000124)
0.1 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.0 GO:0097386 glial cell projection(GO:0097386)
0.0 2.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 1.9 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2 1.8 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.6 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 1.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.3 GO:0042641 actomyosin(GO:0042641)
0.0 1.3 GO:0016580 Sin3 complex(GO:0016580)
0.2 1.2 GO:1990769 proximal neuron projection(GO:1990769)
0.1 1.2 GO:0097433 dense body(GO:0097433)
0.3 1.0 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.0 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.9 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.2 3.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.8 3.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 2.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 2.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 2.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 2.0 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 1.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.5 1.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 1.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.2 GO:0051287 NAD binding(GO:0051287)
0.0 1.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 1.0 GO:0017046 peptide hormone binding(GO:0017046)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.4 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 3.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.5 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 1.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.2 REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock
0.0 1.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.8 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism