Motif ID: KLF6

Z-value: 1.033


Transcription factors associated with KLF6:

Gene SymbolEntrez IDGene Name
KLF6 ENSG00000067082.10 KLF6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF6hg19_v2_chr10_-_3827417_3827473-0.481.7e-02Click!


Activity profile for motif KLF6.

activity profile for motif KLF6


Sorted Z-values histogram for motif KLF6

Sorted Z-values for motif KLF6



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_67465016 3.505 ENST00000326152.5
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr6_-_29595779 3.027 ENST00000355973.3
ENST00000377012.4
GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr13_+_35516390 2.583 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA


neurobeachin


chr6_+_19837592 2.326 ENST00000378700.3
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr17_-_42277203 2.278 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr7_+_106685079 2.110 ENST00000265717.4
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr16_+_69600209 1.951 ENST00000566899.1
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69599861 1.666 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr19_+_45504688 1.665 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr16_+_69599899 1.500 ENST00000567239.1
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69600058 1.282 ENST00000393742.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_+_24495067 1.249 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
ALDH5A1


aldehyde dehydrogenase 5 family, member A1


chr8_-_110656995 1.239 ENST00000276646.9
ENST00000533065.1
SYBU

syntabulin (syntaxin-interacting)

chr3_-_19988462 1.199 ENST00000344838.4
EFHB
EF-hand domain family, member B
chr11_+_45907177 1.186 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr3_-_113415441 1.180 ENST00000491165.1
ENST00000316407.4
KIAA2018

KIAA2018

chr12_-_112450915 1.169 ENST00000437003.2
ENST00000552374.2
ENST00000550831.3
ENST00000354825.3
ENST00000549537.2
ENST00000355445.3
TMEM116





transmembrane protein 116





chr9_-_37465396 1.117 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr1_+_151254738 1.049 ENST00000336715.6
ENST00000324048.5
ENST00000368879.2
ZNF687


zinc finger protein 687


chr17_-_7145475 1.047 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABARAP


GABA(A) receptor-associated protein


chr10_+_45869652 1.043 ENST00000542434.1
ENST00000374391.2
ALOX5

arachidonate 5-lipoxygenase

chr17_-_7120498 1.018 ENST00000485100.1
DLG4
discs, large homolog 4 (Drosophila)
chr11_+_71238313 0.980 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr5_+_42423872 0.978 ENST00000230882.4
ENST00000357703.3
GHR

growth hormone receptor

chr6_+_17281573 0.945 ENST00000379052.5
RBM24
RNA binding motif protein 24
chr11_-_108464465 0.898 ENST00000525344.1
EXPH5
exophilin 5
chr22_-_17602143 0.872 ENST00000331437.3
CECR6
cat eye syndrome chromosome region, candidate 6
chr3_-_121740969 0.870 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
ILDR1


immunoglobulin-like domain containing receptor 1


chr15_-_75743915 0.834 ENST00000394949.4
SIN3A
SIN3 transcription regulator family member A
chr1_+_87797351 0.808 ENST00000370542.1
LMO4
LIM domain only 4
chr19_-_40931891 0.806 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr1_+_151693984 0.805 ENST00000479191.1
RIIAD1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
chr1_-_236445251 0.798 ENST00000354619.5
ENST00000327333.8
ERO1LB

ERO1-like beta (S. cerevisiae)

chr6_+_36164487 0.791 ENST00000357641.6
BRPF3
bromodomain and PHD finger containing, 3
chr2_-_27603582 0.790 ENST00000323703.6
ENST00000436006.1
ZNF513

zinc finger protein 513

chr1_-_227505289 0.789 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr9_-_130742792 0.781 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr2_-_73460334 0.772 ENST00000258083.2
PRADC1
protease-associated domain containing 1
chr6_+_32811885 0.770 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAPSAR1




PSMB9
TAP1 and PSMB8 antisense RNA 1




proteasome (prosome, macropain) subunit, beta type, 9
chr22_-_17602200 0.768 ENST00000399875.1
CECR6
cat eye syndrome chromosome region, candidate 6
chr17_-_1928621 0.762 ENST00000331238.6
RTN4RL1
reticulon 4 receptor-like 1
chr10_+_76586348 0.760 ENST00000372724.1
ENST00000287239.4
ENST00000372714.1
KAT6B


K(lysine) acetyltransferase 6B


chr11_-_108464321 0.736 ENST00000265843.4
EXPH5
exophilin 5
chr20_+_48807351 0.729 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr19_+_8455200 0.717 ENST00000601897.1
ENST00000594216.1
RAB11B

RAB11B, member RAS oncogene family

chr17_-_42276574 0.716 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr5_-_107717058 0.715 ENST00000359660.5
FBXL17
F-box and leucine-rich repeat protein 17
chr8_-_101321584 0.714 ENST00000523167.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr6_-_33285505 0.711 ENST00000431845.2
ZBTB22
zinc finger and BTB domain containing 22
chr1_-_182361327 0.710 ENST00000331872.6
ENST00000311223.5
GLUL

glutamate-ammonia ligase

chr11_+_64009072 0.699 ENST00000535135.1
ENST00000394540.3
FKBP2

FK506 binding protein 2, 13kDa

chr1_+_6845497 0.694 ENST00000473578.1
ENST00000557126.1
CAMTA1

calmodulin binding transcription activator 1

chr3_+_49449636 0.689 ENST00000273590.3
TCTA
T-cell leukemia translocation altered
chr8_-_101322132 0.681 ENST00000523481.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr7_+_128828713 0.673 ENST00000249373.3
SMO
smoothened, frizzled family receptor
chr17_+_53342311 0.652 ENST00000226067.5
HLF
hepatic leukemia factor
chr7_-_72936608 0.642 ENST00000404251.1
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr1_-_182360498 0.640 ENST00000417584.2
GLUL
glutamate-ammonia ligase
chr8_+_67976593 0.640 ENST00000262210.5
ENST00000412460.1
CSPP1

centrosome and spindle pole associated protein 1

chr2_+_85766280 0.634 ENST00000306434.3
MAT2A
methionine adenosyltransferase II, alpha
chr2_-_220436248 0.631 ENST00000265318.4
OBSL1
obscurin-like 1
chr11_+_45918092 0.629 ENST00000395629.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr4_+_26862400 0.628 ENST00000467011.1
ENST00000412829.2
STIM2

stromal interaction molecule 2

chr19_-_47734448 0.620 ENST00000439096.2
BBC3
BCL2 binding component 3
chr20_-_21378666 0.611 ENST00000351817.4
NKX2-4
NK2 homeobox 4
chr17_-_42298201 0.608 ENST00000527034.1
UBTF
upstream binding transcription factor, RNA polymerase I
chr5_+_67511524 0.604 ENST00000521381.1
ENST00000521657.1
PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

chr1_-_182360918 0.603 ENST00000339526.4
GLUL
glutamate-ammonia ligase
chr10_+_124768482 0.598 ENST00000368869.4
ENST00000358776.4
ACADSB

acyl-CoA dehydrogenase, short/branched chain

chr12_+_72233487 0.593 ENST00000482439.2
ENST00000550746.1
ENST00000491063.1
ENST00000319106.8
ENST00000485960.2
ENST00000393309.3
TBC1D15





TBC1 domain family, member 15





chr19_-_55691472 0.591 ENST00000537500.1
SYT5
synaptotagmin V
chr6_+_32811861 0.584 ENST00000453426.1
TAPSAR1
TAP1 and PSMB8 antisense RNA 1
chr17_-_7120525 0.581 ENST00000447163.1
ENST00000399506.2
ENST00000302955.6
DLG4


discs, large homolog 4 (Drosophila)


chr20_-_40247133 0.576 ENST00000373233.3
ENST00000309279.7
CHD6

chromodomain helicase DNA binding protein 6

chr2_-_219433014 0.576 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37




ubiquitin specific peptidase 37




chr7_-_99774945 0.571 ENST00000292377.2
GPC2
glypican 2
chr15_-_75744014 0.566 ENST00000394947.3
ENST00000565264.1
SIN3A

SIN3 transcription regulator family member A

chr6_-_32811771 0.563 ENST00000395339.3
ENST00000374882.3
PSMB8

proteasome (prosome, macropain) subunit, beta type, 8

chr3_-_50540854 0.563 ENST00000423994.2
ENST00000424201.2
ENST00000479441.1
ENST00000429770.1
CACNA2D2



calcium channel, voltage-dependent, alpha 2/delta subunit 2



chr1_-_169455169 0.562 ENST00000367804.4
ENST00000236137.5
SLC19A2

solute carrier family 19 (thiamine transporter), member 2

chr19_-_55691614 0.561 ENST00000592470.1
ENST00000354308.3
SYT5

synaptotagmin V

chr16_-_68482440 0.558 ENST00000219334.5
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr1_-_227505826 0.557 ENST00000334218.5
ENST00000366766.2
ENST00000366764.2
CDC42BPA


CDC42 binding protein kinase alpha (DMPK-like)


chr16_-_49315731 0.556 ENST00000219197.6
CBLN1
cerebellin 1 precursor
chr17_-_79008373 0.555 ENST00000577066.1
ENST00000573167.1
BAIAP2-AS1

BAIAP2 antisense RNA 1 (head to head)

chr3_-_88108192 0.555 ENST00000309534.6
CGGBP1
CGG triplet repeat binding protein 1
chr1_-_23670817 0.551 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr17_+_2240916 0.544 ENST00000574563.1
SGSM2
small G protein signaling modulator 2
chr1_+_21835858 0.543 ENST00000539907.1
ENST00000540617.1
ENST00000374840.3
ALPL


alkaline phosphatase, liver/bone/kidney


chr3_+_88108381 0.542 ENST00000473136.1
RP11-159G9.5
Uncharacterized protein
chr9_-_95896550 0.539 ENST00000375446.4
NINJ1
ninjurin 1
chr13_-_45010939 0.539 ENST00000261489.2
TSC22D1
TSC22 domain family, member 1
chr4_+_88928777 0.532 ENST00000237596.2
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr4_+_26862431 0.522 ENST00000465503.1
STIM2
stromal interaction molecule 2
chr14_-_39901618 0.520 ENST00000554932.1
ENST00000298097.7
FBXO33

F-box protein 33

chr11_-_133826852 0.516 ENST00000533871.2
ENST00000321016.8
IGSF9B

immunoglobulin superfamily, member 9B

chr17_+_30264014 0.512 ENST00000322652.5
ENST00000580398.1
SUZ12

SUZ12 polycomb repressive complex 2 subunit

chr19_-_10764509 0.510 ENST00000591501.1
ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr12_+_124196865 0.507 ENST00000330342.3
ATP6V0A2
ATPase, H+ transporting, lysosomal V0 subunit a2
chr11_-_72492903 0.506 ENST00000537947.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr12_+_56473628 0.499 ENST00000549282.1
ENST00000549061.1
ENST00000267101.3
ERBB3


v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3


chr22_+_31608219 0.493 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
LIMK2


LIM domain kinase 2


chr11_+_64008525 0.490 ENST00000449942.2
FKBP2
FK506 binding protein 2, 13kDa
chr1_+_43148059 0.489 ENST00000321358.7
ENST00000332220.6
YBX1

Y box binding protein 1

chr11_+_57365150 0.489 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1




serpin peptidase inhibitor, clade G (C1 inhibitor), member 1




chr11_+_65479462 0.488 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
KAT5


K(lysine) acetyltransferase 5


chr1_+_40839369 0.487 ENST00000372718.3
SMAP2
small ArfGAP2
chr12_+_110152033 0.487 ENST00000538780.1
FAM222A
family with sequence similarity 222, member A
chr14_+_89029253 0.482 ENST00000251038.5
ENST00000359301.3
ENST00000302216.8
ZC3H14


zinc finger CCCH-type containing 14


chr11_+_68228186 0.481 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3












protein phosphatase 6, regulatory subunit 3












chr19_-_11456905 0.480 ENST00000588560.1
ENST00000592952.1
TMEM205

transmembrane protein 205

chr1_+_33722080 0.480 ENST00000483388.1
ENST00000539719.1
ZNF362

zinc finger protein 362

chr19_+_48673949 0.478 ENST00000328759.7
C19orf68
chromosome 19 open reading frame 68
chr14_-_23770683 0.477 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
PPP1R3E




protein phosphatase 1, regulatory subunit 3E




chr22_-_38484922 0.476 ENST00000428572.1
BAIAP2L2
BAI1-associated protein 2-like 2
chr21_+_43639211 0.475 ENST00000450121.1
ENST00000398449.3
ENST00000361802.2
ABCG1


ATP-binding cassette, sub-family G (WHITE), member 1


chr1_+_36023035 0.474 ENST00000373253.3
NCDN
neurochondrin
chr12_+_112451120 0.463 ENST00000261735.3
ENST00000455836.1
ERP29

endoplasmic reticulum protein 29

chr1_-_35395178 0.460 ENST00000373347.1
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr1_-_165324983 0.456 ENST00000367893.4
LMX1A
LIM homeobox transcription factor 1, alpha
chr3_-_141868357 0.456 ENST00000489671.1
ENST00000475734.1
ENST00000467072.1
ENST00000499676.2
TFDP2



transcription factor Dp-2 (E2F dimerization partner 2)



chr1_-_23670813 0.453 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chrX_+_130192318 0.452 ENST00000370922.1
ARHGAP36
Rho GTPase activating protein 36
chr13_-_41768654 0.451 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr1_+_6845578 0.451 ENST00000467404.2
ENST00000439411.2
CAMTA1

calmodulin binding transcription activator 1

chr10_+_70587279 0.449 ENST00000298596.6
ENST00000399169.4
ENST00000399165.4
ENST00000399162.2
STOX1



storkhead box 1



chr4_+_26862313 0.448 ENST00000467087.1
ENST00000382009.3
ENST00000237364.5
STIM2


stromal interaction molecule 2


chr18_+_60190226 0.448 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr1_+_113615794 0.442 ENST00000361127.5
LRIG2
leucine-rich repeats and immunoglobulin-like domains 2
chr19_-_11456872 0.439 ENST00000586218.1
TMEM205
transmembrane protein 205
chrX_+_40944871 0.439 ENST00000378308.2
ENST00000324545.8
USP9X

ubiquitin specific peptidase 9, X-linked

chr15_+_43803143 0.439 ENST00000382031.1
MAP1A
microtubule-associated protein 1A
chr2_+_24714729 0.435 ENST00000406961.1
ENST00000405141.1
NCOA1

nuclear receptor coactivator 1

chr1_+_114472481 0.435 ENST00000369555.2
HIPK1
homeodomain interacting protein kinase 1
chr9_-_6007787 0.435 ENST00000399933.3
ENST00000381461.2
ENST00000513355.2
KIAA2026


KIAA2026


chr17_-_80231557 0.435 ENST00000392334.2
ENST00000314028.6
CSNK1D

casein kinase 1, delta

chr2_-_97405775 0.434 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
LMAN2L




lectin, mannose-binding 2-like




chr19_+_50094866 0.432 ENST00000418929.2
PRR12
proline rich 12
chr15_-_45480153 0.431 ENST00000560471.1
ENST00000560540.1
SHF

Src homology 2 domain containing F

chr14_-_21945057 0.431 ENST00000397762.1
RAB2B
RAB2B, member RAS oncogene family
chr15_-_56035177 0.428 ENST00000389286.4
ENST00000561292.1
PRTG

protogenin

chr19_-_5978144 0.422 ENST00000340578.6
ENST00000541471.1
ENST00000591736.1
ENST00000587479.1
RANBP3



RAN binding protein 3



chr5_-_81046904 0.422 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr1_-_23670752 0.420 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR




heterogeneous nuclear ribonucleoprotein R




chr11_+_117070037 0.419 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN


transgelin


chr12_+_52445191 0.412 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1





nuclear receptor subfamily 4, group A, member 1





chr1_-_114301960 0.411 ENST00000369598.1
ENST00000369600.1
PHTF1

putative homeodomain transcription factor 1

chr14_+_93897272 0.409 ENST00000393151.2
UNC79
unc-79 homolog (C. elegans)
chr1_-_114302086 0.408 ENST00000369604.1
ENST00000357783.2
PHTF1

putative homeodomain transcription factor 1

chr3_-_53080047 0.408 ENST00000482396.1
ENST00000358080.2
ENST00000296295.6
ENST00000394752.3
SFMBT1



Scm-like with four mbt domains 1



chr19_-_5978090 0.407 ENST00000592621.1
ENST00000034275.8
ENST00000591092.1
ENST00000591333.1
ENST00000590623.1
ENST00000439268.2
ENST00000587159.1
RANBP3






RAN binding protein 3






chr5_+_56111361 0.403 ENST00000399503.3
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr12_+_10365404 0.402 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1





GABA(A) receptor-associated protein like 1





chr11_+_45868957 0.399 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr1_+_156698234 0.396 ENST00000368218.4
ENST00000368216.4
RRNAD1

ribosomal RNA adenine dimethylase domain containing 1

chr8_+_74206829 0.395 ENST00000240285.5
RDH10
retinol dehydrogenase 10 (all-trans)
chr20_+_60813535 0.395 ENST00000358053.2
ENST00000313733.3
ENST00000439951.2
OSBPL2


oxysterol binding protein-like 2


chr3_-_88108212 0.390 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr2_+_42275153 0.390 ENST00000294964.5
PKDCC
protein kinase domain containing, cytoplasmic
chr22_-_30783075 0.384 ENST00000215798.6
RNF215
ring finger protein 215
chr11_-_72492878 0.382 ENST00000535054.1
ENST00000545082.1
STARD10

StAR-related lipid transfer (START) domain containing 10

chr7_+_90225796 0.382 ENST00000380050.3
CDK14
cyclin-dependent kinase 14
chr2_+_74781828 0.381 ENST00000340004.6
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr18_+_3449695 0.381 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr19_+_50084561 0.380 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr1_+_114472222 0.377 ENST00000369558.1
ENST00000369561.4
HIPK1

homeodomain interacting protein kinase 1

chr12_-_96184533 0.376 ENST00000343702.4
ENST00000344911.4
NTN4

netrin 4

chr1_-_154531095 0.372 ENST00000292211.4
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr2_+_10442993 0.371 ENST00000423674.1
ENST00000307845.3
HPCAL1

hippocalcin-like 1

chr5_-_81046841 0.370 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2


single-stranded DNA binding protein 2


chr15_-_43882353 0.369 ENST00000453080.1
ENST00000360301.4
ENST00000360135.4
ENST00000417085.1
ENST00000431962.1
ENST00000334933.4
ENST00000381879.4
ENST00000420765.1
PPIP5K1







diphosphoinositol pentakisphosphate kinase 1







chr6_+_35227449 0.369 ENST00000373953.3
ENST00000440666.2
ENST00000339411.5
ZNF76


zinc finger protein 76


chr6_+_83777374 0.369 ENST00000349129.2
ENST00000237163.5
ENST00000536812.1
DOPEY1


dopey family member 1


chr6_-_137113604 0.366 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr6_+_21593972 0.360 ENST00000244745.1
ENST00000543472.1
SOX4

SRY (sex determining region Y)-box 4

chr15_+_44084040 0.360 ENST00000249786.4
SERF2
small EDRK-rich factor 2
chrX_-_128788914 0.359 ENST00000429967.1
ENST00000307484.6
APLN

apelin

chr2_-_71454185 0.356 ENST00000244221.8
PAIP2B
poly(A) binding protein interacting protein 2B
chr17_-_27278304 0.356 ENST00000577226.1
PHF12
PHD finger protein 12
chr2_-_97535708 0.354 ENST00000305476.5
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr20_+_35201857 0.353 ENST00000373874.2
TGIF2
TGFB-induced factor homeobox 2
chr18_-_72265035 0.353 ENST00000585279.1
ENST00000580048.1
LINC00909

long intergenic non-protein coding RNA 909

chr13_+_88324870 0.353 ENST00000325089.6
SLITRK5
SLIT and NTRK-like family, member 5
chr5_+_56469843 0.348 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr17_+_38498594 0.346 ENST00000394081.3
RARA
retinoic acid receptor, alpha
chr15_-_72410109 0.343 ENST00000564571.1
MYO9A
myosin IXA
chr5_+_56469939 0.336 ENST00000506184.2
GPBP1
GC-rich promoter binding protein 1
chr15_+_96873921 0.334 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr9_-_130517522 0.332 ENST00000373274.3
ENST00000420366.1
SH2D3C

SH2 domain containing 3C

chr6_-_143266297 0.330 ENST00000367603.2
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr1_+_6845384 0.327 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr10_-_103603523 0.324 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr17_+_36861735 0.322 ENST00000378137.5
ENST00000325718.7
MLLT6

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6

chr3_-_171178157 0.320 ENST00000465393.1
ENST00000436636.2
ENST00000369326.5
ENST00000538048.1
ENST00000341852.6
TNIK




TRAF2 and NCK interacting kinase




chr9_-_120177342 0.320 ENST00000361209.2
ASTN2
astrotactin 2
chr16_-_11681023 0.318 ENST00000570904.1
ENST00000574701.1
LITAF

lipopolysaccharide-induced TNF factor

chr5_+_56469775 0.318 ENST00000424459.3
GPBP1
GC-rich promoter binding protein 1
chr6_-_31697563 0.312 ENST00000375789.2
ENST00000416410.1
DDAH2

dimethylarginine dimethylaminohydrolase 2

chr17_-_42298331 0.312 ENST00000343638.5
UBTF
upstream binding transcription factor, RNA polymerase I
chr15_-_83316254 0.312 ENST00000567678.1
ENST00000450751.2
CPEB1

cytoplasmic polyadenylation element binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.5 2.3 GO:0060741 prostate gland stromal morphogenesis(GO:0060741) seminal vesicle development(GO:0061107)
0.4 1.6 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.3 2.1 GO:0097338 response to clozapine(GO:0097338)
0.3 1.0 GO:0009726 detection of endogenous stimulus(GO:0009726)
0.2 1.0 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 4.1 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.2 1.6 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.2 1.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 0.7 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.2 1.2 GO:0009450 acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.2 0.5 GO:0071529 cementum mineralization(GO:0071529)
0.2 7.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 1.6 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.2 0.6 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.4 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.1 0.6 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 0.7 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228) ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) metanephric renal vesicle formation(GO:0072093)
0.1 0.4 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.4 GO:0032240 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.1 1.0 GO:2001300 lipoxin metabolic process(GO:2001300)
0.1 0.5 GO:0043335 protein unfolding(GO:0043335)
0.1 0.7 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1 0.6 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.1 0.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.5 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.1 0.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0021553 olfactory nerve development(GO:0021553)
0.1 0.8 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.3 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 0.9 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 1.0 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 0.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 2.9 GO:0016578 histone deubiquitination(GO:0016578)
0.1 1.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.3 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.1 0.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 1.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.4 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.3 GO:1903281 positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.1 0.5 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.6 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.1 3.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 1.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.5 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.1 0.9 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.1 1.2 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.3 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) histone H3-K36 dimethylation(GO:0097676)
0.1 0.9 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.6 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.6 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.1 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 0.8 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 0.7 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.1 0.3 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.3 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.4 GO:0060431 primary lung bud formation(GO:0060431)
0.1 0.3 GO:0090034 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.1 0.2 GO:1902824 positive regulation of late endosome to lysosome transport(GO:1902824)
0.1 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.2 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 0.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.6 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.1 1.0 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.1 0.2 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.1 0.6 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.6 GO:0042048 olfactory behavior(GO:0042048)
0.1 0.2 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.9 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.1 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.1 0.4 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.3 GO:0009052 D-ribose metabolic process(GO:0006014) pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0 0.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.6 GO:0006685 sphingomyelin catabolic process(GO:0006685) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.6 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.4 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.5 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0060988 lipid tube assembly(GO:0060988)
0.0 0.3 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.2 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.5 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.2 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.2 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.2 GO:0060157 urea transport(GO:0015840) urinary bladder development(GO:0060157)
0.0 1.4 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.6 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.5 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.2 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.0 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.2 GO:0015870 acetylcholine transport(GO:0015870)
0.0 0.2 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.2 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.1 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 2.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.1 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.2 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.0 0.5 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.4 GO:0007625 grooming behavior(GO:0007625)
0.0 0.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 1.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.4 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.2 GO:0010694 transcription from mitochondrial promoter(GO:0006390) positive regulation of alkaline phosphatase activity(GO:0010694)
0.0 0.2 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.4 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.0 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.0 0.3 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.2 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.1 GO:1903301 regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.4 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:1902214 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 0.3 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.5 GO:0009081 branched-chain amino acid metabolic process(GO:0009081)
0.0 0.2 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 1.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.1 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.2 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.4 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 0.1 GO:0042756 drinking behavior(GO:0042756)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)
0.0 0.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 1.0 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.0 0.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.1 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 0.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.6 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 0.0 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.2 GO:0010764 negative regulation of fibroblast migration(GO:0010764)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 1.0 GO:0070195 growth hormone receptor complex(GO:0070195)
0.2 1.2 GO:1990769 proximal neuron projection(GO:1990769)
0.2 1.8 GO:0044294 dendritic growth cone(GO:0044294)
0.2 0.6 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.2 0.8 GO:0005667 transcription factor complex(GO:0005667)
0.2 3.0 GO:0000124 SAGA complex(GO:0000124)
0.2 1.9 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2 0.6 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 1.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.6 GO:0060187 cell pole(GO:0060187)
0.1 1.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.6 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.5 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.9 GO:0061689 tricellular tight junction(GO:0061689)
0.1 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.2 GO:0097433 dense body(GO:0097433)
0.1 0.6 GO:1990393 3M complex(GO:1990393)
0.1 0.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 2.0 GO:0097386 glial cell projection(GO:0097386)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.3 GO:0042641 actomyosin(GO:0042641)
0.1 0.5 GO:0001739 sex chromatin(GO:0001739)
0.0 0.9 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.0 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.0 1.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.5 GO:0071439 clathrin complex(GO:0071439)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0035859 Seh1-associated complex(GO:0035859)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.0 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 2.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.7 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.8 3.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.5 1.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.5 2.0 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.3 0.9 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.2 0.6 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.2 0.5 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 1.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.5 GO:0043398 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
0.1 0.9 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 1.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.4 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.6 GO:0043559 insulin binding(GO:0043559)
0.1 0.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.4 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.5 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.3 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 0.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.6 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.8 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.5 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 1.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.5 GO:0034056 estrogen response element binding(GO:0034056)
0.0 3.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.5 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.3 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.7 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.8 GO:0035173 histone kinase activity(GO:0035173)
0.0 1.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 1.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.5 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0051117 ATPase binding(GO:0051117)
0.0 2.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.0 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.4 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 1.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.1 GO:0000832 inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) inositol hexakisphosphate kinase activity(GO:0000828) inositol heptakisphosphate kinase activity(GO:0000829) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 2.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 6.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.2 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.0 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.0 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.0 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 2.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.4 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.9 PID_IL12_2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 1.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.1 REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.4 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.8 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.5 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 3.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.2 REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock
0.0 0.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.4 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production