Motif ID: KLF8

Z-value: 0.901


Transcription factors associated with KLF8:

Gene SymbolEntrez IDGene Name
KLF8 ENSG00000102349.10 KLF8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF8hg19_v2_chrX_+_56258844_562588820.655.2e-04Click!


Activity profile for motif KLF8.

activity profile for motif KLF8


Sorted Z-values histogram for motif KLF8

Sorted Z-values for motif KLF8



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487282 2.173 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
 KLK7


kallikrein-related peptidase 7


chr19_-_51456198 2.140 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr2_-_241396131 2.101 ENST00000404327.3
 AC110619.2
Uncharacterized protein
chr19_-_51466681 2.009 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chr22_+_38071615 1.860 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr2_-_241396106 1.734 ENST00000404891.1
 AC110619.2
Uncharacterized protein
chr2_+_95691445 1.729 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
 MAL


mal, T-cell differentiation protein


chr11_-_568369 1.722 ENST00000534540.1
ENST00000528245.1
ENST00000500447.1
ENST00000533920.1
 MIR210HG



MIR210 host gene (non-protein coding)



chr2_+_95691417 1.697 ENST00000309988.4
 MAL
mal, T-cell differentiation protein
chr19_+_917287 1.689 ENST00000592648.1
ENST00000234371.5
 KISS1R

KISS1 receptor

chr19_-_51456321 1.644 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr19_-_51456344 1.622 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr8_+_86376081 1.435 ENST00000285379.5
 CA2
carbonic anhydrase II
chr21_-_47352477 1.398 ENST00000593412.1
 PRED62
Uncharacterized protein
chr19_-_51471381 1.390 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51504411 1.234 ENST00000593490.1
 KLK8
kallikrein-related peptidase 8
chr9_+_128509624 1.143 ENST00000342287.5
ENST00000373487.4
 PBX3

pre-B-cell leukemia homeobox 3

chr6_-_4135693 1.047 ENST00000495548.1
ENST00000380125.2
ENST00000465828.1
 ECI2


enoyl-CoA delta isomerase 2


chr17_+_42081914 1.004 ENST00000293404.3
ENST00000589767.1
 NAGS

N-acetylglutamate synthase

chr1_+_150522222 0.998 ENST00000369039.5
 ADAMTSL4
ADAMTS-like 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 887 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 8.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 4.5 GO:0070268 cornification(GO:0070268)
0.3 3.6 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 3.3 GO:0016540 protein autoprocessing(GO:0016540)
0.0 3.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 2.4 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.6 2.2 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.3 2.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.2 2.1 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 2.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 2.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 2.0 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.4 1.9 GO:0002317 plasma cell differentiation(GO:0002317)
0.2 1.8 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 1.8 GO:0001778 plasma membrane repair(GO:0001778)
0.3 1.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 1.7 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 1.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.5 1.6 GO:0042938 dipeptide transport(GO:0042938)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 261 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 4.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 3.9 GO:0001533 cornified envelope(GO:0001533)
0.0 2.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 2.4 GO:0030673 axolemma(GO:0030673)
0.0 2.4 GO:0001726 ruffle(GO:0001726)
0.0 2.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 2.2 GO:0005811 lipid particle(GO:0005811)
0.2 2.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.1 1.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.3 1.5 GO:0032449 CBM complex(GO:0032449)
0.2 1.5 GO:0005610 laminin-5 complex(GO:0005610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 509 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.7 GO:0005179 hormone activity(GO:0005179)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.0 GO:0051015 actin filament binding(GO:0051015)
0.2 3.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 3.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.7 GO:0002020 protease binding(GO:0002020)
0.0 2.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 2.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 2.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.0 GO:0048185 activin binding(GO:0048185)
0.1 2.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 1.9 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.5 1.9 GO:0030395 lactose binding(GO:0030395)
0.1 1.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 1.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.8 GO:0008199 ferric iron binding(GO:0008199)
0.1 1.8 GO:0019841 retinol binding(GO:0019841)
0.0 1.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 7.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 3.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 2.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.0 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 4.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 4.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.8 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 3.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 2.7 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 2.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 2.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 2.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 1.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.5 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.4 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.4 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism