Motif ID: LEF1

Z-value: 0.946


Transcription factors associated with LEF1:

Gene SymbolEntrez IDGene Name
LEF1 ENSG00000138795.5 LEF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109088940_109089037,
hg19_v2_chr4_-_109087872_109087881
-0.164.6e-01Click!


Activity profile for motif LEF1.

activity profile for motif LEF1


Sorted Z-values histogram for motif LEF1

Sorted Z-values for motif LEF1



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_141747950 1.603 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_+_137514687 1.029 ENST00000394894.3
KIF20A
kinesin family member 20A
chr5_-_146833485 1.017 ENST00000398514.3
DPYSL3
dihydropyrimidinase-like 3
chr1_+_82266053 0.982 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2






latrophilin 2






chrX_+_38420783 0.957 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7


tetraspanin 7


chr5_+_137514834 0.905 ENST00000508792.1
ENST00000504621.1
KIF20A

kinesin family member 20A

chr2_-_1748214 0.826 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
PXDN


peroxidasin homolog (Drosophila)


chr11_-_75017734 0.819 ENST00000532525.1
ARRB1
arrestin, beta 1
chr3_-_112320749 0.751 ENST00000610103.1
RP11-572C15.6
RP11-572C15.6
chr8_-_133772794 0.735 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71




transmembrane protein 71




chr14_-_61124977 0.728 ENST00000554986.1
SIX1
SIX homeobox 1
chr3_-_112360116 0.728 ENST00000206423.3
ENST00000439685.2
CCDC80

coiled-coil domain containing 80

chr7_-_148581251 0.692 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2


enhancer of zeste homolog 2 (Drosophila)


chr2_+_162272605 0.683 ENST00000389554.3
TBR1
T-box, brain, 1
chr7_-_148581360 0.683 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr7_-_19813192 0.645 ENST00000422233.1
ENST00000433641.1
TMEM196

transmembrane protein 196

chr7_-_25268104 0.642 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr3_-_71179699 0.632 ENST00000497355.1
FOXP1
forkhead box P1
chrX_-_80457385 0.623 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5


high mobility group nucleosome binding domain 5


chr4_+_95972822 0.619 ENST00000509540.1
ENST00000440890.2
BMPR1B

bone morphogenetic protein receptor, type IB

chr2_+_233734994 0.606 ENST00000331342.2
C2orf82
chromosome 2 open reading frame 82
chr5_+_54455946 0.603 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8


glutathione peroxidase 8 (putative)


chr9_-_23826298 0.602 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr9_-_27005686 0.591 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr3_-_71179988 0.591 ENST00000491238.1
FOXP1
forkhead box P1
chr6_-_153304148 0.575 ENST00000229758.3
FBXO5
F-box protein 5
chr1_+_47799542 0.575 ENST00000471289.2
ENST00000450808.2
CMPK1

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

chr20_+_37554955 0.575 ENST00000217429.4
FAM83D
family with sequence similarity 83, member D
chr3_+_111260856 0.572 ENST00000352690.4
CD96
CD96 molecule
chr5_+_161274940 0.550 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr3_+_19189946 0.545 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr6_-_153304697 0.540 ENST00000367241.3
FBXO5
F-box protein 5
chr5_+_161494521 0.536 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr9_+_101705893 0.533 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr14_+_54863667 0.512 ENST00000335183.6
CDKN3
cyclin-dependent kinase inhibitor 3
chr3_-_71353892 0.512 ENST00000484350.1
FOXP1
forkhead box P1
chr1_+_196743943 0.509 ENST00000471440.2
ENST00000391985.3
CFHR3

complement factor H-related 3

chr14_+_54863739 0.504 ENST00000541304.1
CDKN3
cyclin-dependent kinase inhibitor 3
chr3_-_141747439 0.503 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr14_+_54863682 0.501 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
CDKN3



cyclin-dependent kinase inhibitor 3



chrX_+_46937745 0.493 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN


regucalcin


chr1_-_205419053 0.488 ENST00000367154.1
LEMD1
LEM domain containing 1
chr10_-_69597915 0.480 ENST00000225171.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr7_+_7811992 0.479 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr6_-_64029879 0.476 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN


lengsin, lens protein with glutamine synthetase domain


chr2_-_86564776 0.469 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1


receptor accessory protein 1


chr2_-_47572105 0.468 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4



AC073283.4



chr1_+_196743912 0.466 ENST00000367425.4
CFHR3
complement factor H-related 3
chr3_+_39509163 0.463 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP


myelin-associated oligodendrocyte basic protein


chrX_-_48328631 0.460 ENST00000429543.1
ENST00000317669.5
SLC38A5

solute carrier family 38, member 5

chr17_-_46623441 0.457 ENST00000330070.4
HOXB2
homeobox B2
chr5_+_161494770 0.456 ENST00000414552.2
ENST00000361925.4
GABRG2

gamma-aminobutyric acid (GABA) A receptor, gamma 2

chrX_-_48328551 0.455 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chr1_-_226496772 0.446 ENST00000359525.2
ENST00000460719.1
LIN9

lin-9 homolog (C. elegans)

chr17_-_63557759 0.445 ENST00000307078.5
AXIN2
axin 2
chr10_+_114710425 0.442 ENST00000352065.5
ENST00000369395.1
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chrX_-_100183894 0.439 ENST00000328526.5
ENST00000372956.2
XKRX

XK, Kell blood group complex subunit-related, X-linked

chr12_-_16759711 0.438 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_157189180 0.431 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2




nuclear receptor subfamily 4, group A, member 2




chr9_-_94186131 0.429 ENST00000297689.3
NFIL3
nuclear factor, interleukin 3 regulated
chr8_-_16859690 0.427 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr5_+_126112794 0.421 ENST00000261366.5
ENST00000395354.1
LMNB1

lamin B1

chr11_-_41481135 0.419 ENST00000528697.1
ENST00000530763.1
LRRC4C

leucine rich repeat containing 4C

chr10_-_17171817 0.419 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr8_-_124553437 0.417 ENST00000517956.1
ENST00000443022.2
FBXO32

F-box protein 32

chr9_+_116638562 0.416 ENST00000374126.5
ENST00000288466.7
ZNF618

zinc finger protein 618

chr5_-_65017921 0.397 ENST00000381007.4
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr15_-_37392086 0.395 ENST00000561208.1
MEIS2
Meis homeobox 2
chr7_+_120628731 0.395 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr3_+_39509070 0.393 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP





myelin-associated oligodendrocyte basic protein





chr9_+_84304628 0.388 ENST00000437181.1
RP11-154D17.1
RP11-154D17.1
chr11_-_85430163 0.385 ENST00000529581.1
ENST00000533577.1
SYTL2

synaptotagmin-like 2

chr11_-_85430204 0.384 ENST00000389958.3
ENST00000527794.1
SYTL2

synaptotagmin-like 2

chr15_-_74495188 0.384 ENST00000563965.1
ENST00000395105.4
STRA6

stimulated by retinoic acid 6

chrX_+_95939711 0.381 ENST00000373049.4
ENST00000324765.8
DIAPH2

diaphanous-related formin 2

chrX_+_95939638 0.378 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2


diaphanous-related formin 2


chr19_+_751122 0.376 ENST00000215582.6
MISP
mitotic spindle positioning
chr7_+_73245193 0.370 ENST00000340958.2
CLDN4
claudin 4
chr5_+_172068232 0.367 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B


neuralized E3 ubiquitin protein ligase 1B


chr2_+_58655461 0.366 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1


long intergenic non-protein coding RNA 1122


chr21_-_32185570 0.364 ENST00000329621.4
KRTAP8-1
keratin associated protein 8-1
chr11_+_5410607 0.359 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr19_+_13906250 0.357 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr8_-_93107696 0.355 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1


runt-related transcription factor 1; translocated to, 1 (cyclin D-related)


chr13_-_36429763 0.352 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr6_+_135502466 0.349 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr7_-_25702669 0.345 ENST00000446840.1
AC003090.1
AC003090.1
chr20_+_30555805 0.341 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr7_-_99698338 0.340 ENST00000354230.3
ENST00000425308.1
MCM7

minichromosome maintenance complex component 7

chr2_+_27665232 0.339 ENST00000543753.1
ENST00000288873.3
KRTCAP3

keratinocyte associated protein 3

chr5_-_137674000 0.334 ENST00000510119.1
ENST00000513970.1
CDC25C

cell division cycle 25C

chr3_-_148804275 0.332 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF



helicase-like transcription factor



chr7_+_28452130 0.330 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chr6_+_135502408 0.330 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB


v-myb avian myeloblastosis viral oncogene homolog


chr17_+_80416050 0.328 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF


nuclear prelamin A recognition factor


chr13_-_24895566 0.325 ENST00000422229.2
AL359736.1
protein PCOTH isoform 1
chr13_+_30002741 0.322 ENST00000380808.2
MTUS2
microtubule associated tumor suppressor candidate 2
chr17_-_43025005 0.320 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
KIF18B


kinesin family member 18B


chrY_-_15591485 0.320 ENST00000382896.4
ENST00000537580.1
ENST00000540140.1
ENST00000545955.1
ENST00000538878.1
UTY




ubiquitously transcribed tetratricopeptide repeat containing, Y-linked




chr3_-_147124547 0.319 ENST00000491672.1
ENST00000383075.3
ZIC4

Zic family member 4

chr2_+_27665289 0.313 ENST00000407293.1
KRTCAP3
keratinocyte associated protein 3
chr2_+_176994408 0.312 ENST00000429017.1
ENST00000313173.4
ENST00000544999.1
HOXD8


homeobox D8


chr9_+_133971909 0.309 ENST00000247291.3
ENST00000372302.1
ENST00000372300.1
ENST00000372298.1
AIF1L



allograft inflammatory factor 1-like



chr12_+_1738363 0.309 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr18_-_74728998 0.308 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP










myelin basic protein










chr5_+_31193847 0.308 ENST00000514738.1
ENST00000265071.2
CDH6

cadherin 6, type 2, K-cadherin (fetal kidney)

chr6_-_15586238 0.305 ENST00000462989.2
DTNBP1
dystrobrevin binding protein 1
chr4_-_23891658 0.305 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_+_71494461 0.303 ENST00000396073.3
ENAM
enamelin
chr17_+_79679299 0.303 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr9_+_133971863 0.301 ENST00000372309.3
AIF1L
allograft inflammatory factor 1-like
chr11_+_112832133 0.300 ENST00000524665.1
NCAM1
neural cell adhesion molecule 1
chr10_+_114710211 0.299 ENST00000349937.2
ENST00000369397.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr7_-_29234802 0.297 ENST00000449801.1
ENST00000409850.1
CPVL

carboxypeptidase, vitellogenic-like

chr18_+_72922710 0.297 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr3_+_182983090 0.296 ENST00000465010.1
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr13_+_24144509 0.295 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chrX_-_135962876 0.290 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX



RNA binding motif protein, X-linked



chr19_-_49864746 0.290 ENST00000598810.1
TEAD2
TEA domain family member 2
chr12_-_16761007 0.289 ENST00000354662.1
ENST00000441439.2
LMO3

LIM domain only 3 (rhombotin-like 2)

chrX_-_43832711 0.286 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr5_+_170846640 0.282 ENST00000274625.5
FGF18
fibroblast growth factor 18
chr11_-_57298187 0.281 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
TIMM10


translocase of inner mitochondrial membrane 10 homolog (yeast)


chr14_+_85996471 0.281 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr2_+_70056762 0.273 ENST00000282570.3
GMCL1
germ cell-less, spermatogenesis associated 1
chr16_+_70332956 0.271 ENST00000288071.6
ENST00000393657.2
ENST00000355992.3
ENST00000567706.1
DDX19B


RP11-529K1.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B


Uncharacterized protein
chr15_-_37393406 0.270 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2


Meis homeobox 2


chrX_+_69488155 0.269 ENST00000374495.3
ARR3
arrestin 3, retinal (X-arrestin)
chr4_+_96012614 0.269 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr18_-_74207146 0.266 ENST00000443185.2
ZNF516
zinc finger protein 516
chr21_+_39628852 0.264 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr7_+_129847688 0.264 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chr1_+_100111580 0.263 ENST00000605497.1
PALMD
palmdelphin
chr1_-_216896780 0.263 ENST00000459955.1
ENST00000366937.1
ENST00000408911.3
ENST00000391890.3
ESRRG



estrogen-related receptor gamma



chr11_-_75917569 0.263 ENST00000322563.3
WNT11
wingless-type MMTV integration site family, member 11
chrX_+_54835493 0.262 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr6_-_112575838 0.262 ENST00000455073.1
LAMA4
laminin, alpha 4
chr12_+_54378923 0.262 ENST00000303460.4
HOXC10
homeobox C10
chr14_+_61201445 0.260 ENST00000261245.4
ENST00000539616.2
MNAT1

MNAT CDK-activating kinase assembly factor 1

chr15_-_37391614 0.260 ENST00000219869.9
MEIS2
Meis homeobox 2
chr21_+_33784670 0.259 ENST00000300255.2
EVA1C
eva-1 homolog C (C. elegans)
chrX_+_37545012 0.259 ENST00000378616.3
XK
X-linked Kx blood group (McLeod syndrome)
chr11_-_66445219 0.256 ENST00000525754.1
ENST00000531969.1
ENST00000524637.1
ENST00000531036.2
ENST00000310046.4
RBM4B




RNA binding motif protein 4B




chr17_+_79679369 0.252 ENST00000350690.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr7_-_47621736 0.251 ENST00000311160.9
TNS3
tensin 3
chr17_-_79849438 0.251 ENST00000331204.4
ENST00000505490.2
ALYREF

Aly/REF export factor

chr12_+_54402790 0.249 ENST00000040584.4
HOXC8
homeobox C8
chr10_+_114710516 0.248 ENST00000542695.1
ENST00000346198.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr8_-_93107827 0.248 ENST00000520724.1
ENST00000518844.1
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr15_+_50474385 0.247 ENST00000267842.5
SLC27A2
solute carrier family 27 (fatty acid transporter), member 2
chr3_+_141105235 0.247 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr15_-_41120896 0.246 ENST00000299174.5
ENST00000427255.2
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr16_-_22385901 0.245 ENST00000268383.2
CDR2
cerebellar degeneration-related protein 2, 62kDa
chr4_+_95128748 0.245 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr22_-_32860427 0.244 ENST00000534972.1
ENST00000397450.1
ENST00000397452.1
BPIFC


BPI fold containing family C


chr15_-_101792137 0.244 ENST00000254190.3
CHSY1
chondroitin sulfate synthase 1
chr21_+_35552978 0.244 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310


long intergenic non-protein coding RNA 310


chr1_+_84630367 0.244 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr19_-_48048518 0.243 ENST00000595558.1
ENST00000263351.5
ZNF541

zinc finger protein 541

chrX_+_36254051 0.242 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr22_-_23484246 0.241 ENST00000216036.4
RTDR1
rhabdoid tumor deletion region gene 1
chr18_-_24445729 0.241 ENST00000383168.4
AQP4
aquaporin 4
chr6_+_143929307 0.239 ENST00000427704.2
ENST00000305766.6
PHACTR2

phosphatase and actin regulator 2

chr4_-_70505358 0.239 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
UGT2A2


UDP glucuronosyltransferase 2 family, polypeptide A2


chr2_+_204732666 0.238 ENST00000295854.6
ENST00000472206.1
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr6_+_90604188 0.236 ENST00000369352.1
GJA10
gap junction protein, alpha 10, 62kDa
chr2_-_175629164 0.235 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1


cholinergic receptor, nicotinic, alpha 1 (muscle)


chr8_+_63161491 0.232 ENST00000523211.1
ENST00000524201.1
NKAIN3

Na+/K+ transporting ATPase interacting 3

chr4_-_123377880 0.232 ENST00000226730.4
IL2
interleukin 2
chr4_+_102734967 0.232 ENST00000444316.2
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr11_+_112130988 0.232 ENST00000595053.1
AP002884.2
LOC100132686 protein; Uncharacterized protein
chr17_-_56065484 0.230 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr16_-_3350614 0.228 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr5_-_96478466 0.227 ENST00000274382.4
LIX1
Lix1 homolog (chicken)
chr1_+_223101757 0.226 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr1_+_215256467 0.225 ENST00000391894.2
ENST00000444842.2
KCNK2

potassium channel, subfamily K, member 2

chr2_+_172864490 0.224 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr10_-_101380121 0.223 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr3_-_33686925 0.221 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2


cytoplasmic linker associated protein 2


chr1_-_226496898 0.221 ENST00000481685.1
LIN9
lin-9 homolog (C. elegans)
chr11_+_65408273 0.221 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chr1_-_156542328 0.220 ENST00000361170.2
IQGAP3
IQ motif containing GTPase activating protein 3
chr11_+_126081662 0.219 ENST00000528985.1
ENST00000529731.1
ENST00000360194.4
ENST00000530043.1
FAM118B



family with sequence similarity 118, member B



chr12_+_9067123 0.218 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr5_+_93954039 0.215 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr8_+_79578282 0.214 ENST00000263849.4
ZC2HC1A
zinc finger, C2HC-type containing 1A
chr11_+_112832202 0.214 ENST00000534015.1
NCAM1
neural cell adhesion molecule 1
chr9_-_113341985 0.213 ENST00000374469.1
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr7_-_41742697 0.213 ENST00000242208.4
INHBA
inhibin, beta A
chr11_-_85430088 0.212 ENST00000533057.1
ENST00000533892.1
SYTL2

synaptotagmin-like 2

chr1_+_100111479 0.212 ENST00000263174.4
PALMD
palmdelphin
chr3_+_107244229 0.211 ENST00000456419.1
ENST00000402163.2
BBX

bobby sox homolog (Drosophila)

chr2_+_179184955 0.211 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr10_+_114709999 0.210 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2






transcription factor 7-like 2 (T-cell specific, HMG-box)






chr17_-_39637392 0.210 ENST00000246639.2
ENST00000393989.1
KRT35

keratin 35

chr4_+_95129061 0.210 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_+_174577070 0.209 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr11_-_8285405 0.209 ENST00000335790.3
ENST00000534484.1
LMO1

LIM domain only 1 (rhombotin 1)

chr11_+_7273181 0.208 ENST00000318881.6
SYT9
synaptotagmin IX
chr7_-_22233442 0.208 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.4 1.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.3 1.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.3 0.8 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.3 0.8 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 1.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.2 0.6 GO:0021569 rhombomere 3 development(GO:0021569)
0.2 0.6 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.2 0.7 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2 0.9 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 0.5 GO:1903625 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.1 0.4 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.6 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.1 0.5 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.7 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.5 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 0.4 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 0.7 GO:0021764 amygdala development(GO:0021764)
0.1 0.3 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.2 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.3 GO:0060775 mediolateral intercalation(GO:0060031) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775)
0.1 0.3 GO:0031133 regulation of axon diameter(GO:0031133)
0.1 0.9 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 1.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.4 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 1.0 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 0.2 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.1 0.8 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.1 0.2 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.1 0.6 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 0.2 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 1.0 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 0.9 GO:0015816 glycine transport(GO:0015816)
0.1 0.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.3 GO:0048286 lung alveolus development(GO:0048286)
0.1 0.2 GO:0060931 sinoatrial node cell development(GO:0060931)
0.1 0.2 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 0.4 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.4 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.2 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 0.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.2 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.1 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.1 0.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.3 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.2 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 2.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 0.2 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.1 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.2 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 1.1 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.7 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.4 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:2000809 positive regulation of presynaptic membrane organization(GO:1901631) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.0 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.0 0.4 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.3 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.5 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.2 GO:1904396 regulation of neuromuscular junction development(GO:1904396)
0.0 0.3 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.3 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.1 GO:0003358 noradrenergic neuron development(GO:0003358)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.2 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.0 0.1 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.3 GO:0097106 postsynaptic density organization(GO:0097106)
0.0 0.2 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.5 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.1 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:0035948 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:0072708 response to sorbitol(GO:0072708) cellular response to sorbitol(GO:0072709)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.3 GO:0007512 adult heart development(GO:0007512)
0.0 0.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.0 0.3 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.3 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.2 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.2 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.0 GO:0048880 sensory system development(GO:0048880)
0.0 0.1 GO:2001270 regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.0 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.2 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.2 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.1 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.0 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.1 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:1904783 positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.0 0.1 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.1 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 2.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.1 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.1 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763) regulation of glutamate metabolic process(GO:2000211)
0.0 0.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0031936 DNA replication-dependent nucleosome assembly(GO:0006335) negative regulation of chromatin silencing(GO:0031936) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:0050893 sensory processing(GO:0050893)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.3 GO:0051923 sulfation(GO:0051923)
0.0 0.6 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.0 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.0 0.8 GO:0008542 visual learning(GO:0008542)
0.0 0.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.0 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 0.1 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.2 GO:0007625 grooming behavior(GO:0007625)
0.0 0.3 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.1 GO:0060346 bone trabecula formation(GO:0060346)
0.0 0.6 GO:0051310 metaphase plate congression(GO:0051310)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.9 GO:0005638 lamin filament(GO:0005638)
0.1 0.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 1.4 GO:0045120 pronucleus(GO:0045120)
0.1 0.7 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.1 0.2 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.3 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 1.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.3 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.0 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0005605 basal lamina(GO:0005605)
0.0 0.0 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 1.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 1.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 0.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.2 0.6 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.2 0.6 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.2 0.8 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.2 1.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.6 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.5 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.5 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 1.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 1.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.3 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 1.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.3 GO:0002046 opsin binding(GO:0002046)
0.1 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.4 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.1 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.9 GO:0043621 protein self-association(GO:0043621)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.4 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 2.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 0.7 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors