Motif ID: LEF1

Z-value: 0.946


Transcription factors associated with LEF1:

Gene SymbolEntrez IDGene Name
LEF1 ENSG00000138795.5 LEF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109088940_109089037,
hg19_v2_chr4_-_109087872_109087881		-0.164.6e-01Click!


Activity profile for motif LEF1.

activity profile for motif LEF1


Sorted Z-values histogram for motif LEF1

Sorted Z-values for motif LEF1



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_141747950 1.603 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_+_137514687 1.029 ENST00000394894.3
 KIF20A
kinesin family member 20A
chr5_-_146833485 1.017 ENST00000398514.3
 DPYSL3
dihydropyrimidinase-like 3
chr1_+_82266053 0.982 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
 LPHN2






latrophilin 2






chrX_+_38420783 0.957 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
 TSPAN7


tetraspanin 7


chr5_+_137514834 0.905 ENST00000508792.1
ENST00000504621.1
 KIF20A

kinesin family member 20A

chr2_-_1748214 0.826 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
 PXDN


peroxidasin homolog (Drosophila)


chr11_-_75017734 0.819 ENST00000532525.1
 ARRB1
arrestin, beta 1
chr3_-_112320749 0.751 ENST00000610103.1
 RP11-572C15.6
RP11-572C15.6
chr8_-_133772794 0.735 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
 TMEM71




transmembrane protein 71




chr14_-_61124977 0.728 ENST00000554986.1
 SIX1
SIX homeobox 1
chr3_-_112360116 0.728 ENST00000206423.3
ENST00000439685.2
 CCDC80

coiled-coil domain containing 80

chr7_-_148581251 0.692 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
 EZH2


enhancer of zeste homolog 2 (Drosophila)


chr2_+_162272605 0.683 ENST00000389554.3
 TBR1
T-box, brain, 1
chr7_-_148581360 0.683 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
 EZH2



enhancer of zeste homolog 2 (Drosophila)



chr7_-_19813192 0.645 ENST00000422233.1
ENST00000433641.1
 TMEM196

transmembrane protein 196

chr7_-_25268104 0.642 ENST00000222674.2
 NPVF
neuropeptide VF precursor
chr3_-_71179699 0.632 ENST00000497355.1
 FOXP1
forkhead box P1
chrX_-_80457385 0.623 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
 HMGN5


high mobility group nucleosome binding domain 5


chr4_+_95972822 0.619 ENST00000509540.1
ENST00000440890.2
 BMPR1B

bone morphogenetic protein receptor, type IB


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 2.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.3 1.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.5 1.4 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2 1.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.4 1.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.0 1.1 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.0 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 1.0 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 0.9 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.9 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 0.9 GO:0015816 glycine transport(GO:0015816)
0.3 0.8 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.3 0.8 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.8 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.0 0.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.8 GO:0008542 visual learning(GO:0008542)
0.2 0.7 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 1.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.4 GO:0045120 pronucleus(GO:0045120)
0.0 1.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.9 GO:0005638 lamin filament(GO:0005638)
0.1 0.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.1 0.7 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 0.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.9 GO:0043621 protein self-association(GO:0043621)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 1.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 1.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 1.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 0.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 0.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 0.8 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 0.7 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones