Motif ID: LHX2

Z-value: 0.373


Transcription factors associated with LHX2:

Gene SymbolEntrez IDGene Name
LHX2 ENSG00000106689.6 LHX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LHX2hg19_v2_chr9_+_126777676_126777700,
hg19_v2_chr9_+_126773880_126773895		-0.145.0e-01Click!


Activity profile for motif LHX2.

activity profile for motif LHX2


Sorted Z-values histogram for motif LHX2

Sorted Z-values for motif LHX2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_38859996 1.770 ENST00000264651.2
 KRT24
keratin 24
chr18_+_29027696 1.305 ENST00000257189.4
 DSG3
desmoglein 3
chr4_+_69313145 1.246 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr6_-_131291572 0.782 ENST00000529208.1
 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr6_+_53883790 0.710 ENST00000509997.1
 MLIP
muscular LMNA-interacting protein
chr9_+_105757590 0.677 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr19_+_15838834 0.638 ENST00000305899.3
 OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr1_+_152975488 0.606 ENST00000542696.1
 SPRR3
small proline-rich protein 3
chr3_+_57882024 0.586 ENST00000494088.1
 SLMAP
sarcolemma associated protein
chr6_+_53883708 0.541 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
 MLIP


muscular LMNA-interacting protein


chr19_+_42212501 0.493 ENST00000398599.4
 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr11_-_62323702 0.459 ENST00000530285.1
 AHNAK
AHNAK nucleoprotein
chr14_-_34420259 0.447 ENST00000250457.3
ENST00000547327.2
 EGLN3

egl-9 family hypoxia-inducible factor 3

chr6_+_26199737 0.436 ENST00000359985.1
 HIST1H2BF
histone cluster 1, H2bf
chr19_+_42212526 0.434 ENST00000221992.6
ENST00000405816.1
ENST00000598976.1
ENST00000435837.2
 CEACAM5

CEA

carcinoembryonic antigen-related cell adhesion molecule 5

Uncharacterized protein

chr4_-_109541539 0.428 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
 RPL34-AS1


RPL34 antisense RNA 1 (head to head)


chr18_+_34124507 0.428 ENST00000591635.1
 FHOD3
formin homology 2 domain containing 3
chr1_+_62439037 0.414 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr1_+_192127578 0.412 ENST00000367460.3
 RGS18
regulator of G-protein signaling 18
chr14_+_56584414 0.408 ENST00000559044.1
 PELI2
pellino E3 ubiquitin protein ligase family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0070268 cornification(GO:0070268)
0.0 0.9 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.1 0.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.8 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.7 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.6 GO:0031424 keratinization(GO:0031424)
0.1 0.4 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.3 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.2 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0005882 intermediate filament(GO:0005882)
0.0 1.3 GO:0030057 desmosome(GO:0030057)
0.0 0.9 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.8 GO:0008091 spectrin(GO:0008091)
0.2 0.7 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0001533 cornified envelope(GO:0001533)
0.1 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.8 GO:0042731 PH domain binding(GO:0042731)
0.0 0.7 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.6 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.5 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.4 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.4 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0017166 vinculin binding(GO:0017166)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.2 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins