ISMARA results: LHX3

Motif ID: LHX3

Z-value: 0.347

Transcription factors associated with LHX3:

Gene Symbol	Entrez ID	Gene Name
LHX3	ENSG00000107187.11	LHX3

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
LHX3	hg19_v2_chr9_-_139094988_139095012, hg19_v2_chr9_-_139096955_139096979	-0.39	5.7e-02	Click!

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Top targets:

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Showing 1 to 20 of 139 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrX_-_13835147	0.402	ENST00000493677.1 ENST00000355135.2	GPM6B	glycoprotein M6B
chr9_-_75567962	0.361	ENST00000297785.3 ENST00000376939.1	ALDH1A1	aldehyde dehydrogenase 1 family, member A1
chr12_-_10282836	0.357	ENST00000304084.8 ENST00000353231.5 ENST00000525605.1	CLEC7A	C-type lectin domain family 7, member A
chr19_+_11457232	0.298	ENST00000587531.1	CCDC159	coiled-coil domain containing 159
chr12_-_10282681	0.276	ENST00000533022.1	CLEC7A	C-type lectin domain family 7, member A
chr12_-_10282742	0.273	ENST00000298523.5 ENST00000396484.2 ENST00000310002.4	CLEC7A	C-type lectin domain family 7, member A
chr17_+_68071458	0.264	ENST00000589377.1	KCNJ16	potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389	0.254	ENST00000283936.1 ENST00000392671.1	KCNJ16	potassium inwardly-rectifying channel, subfamily J, member 16
chr19_+_49199209	0.247	ENST00000522966.1 ENST00000425340.2 ENST00000391876.4	FUT2	fucosyltransferase 2 (secretor status included)
chr19_+_50016411	0.219	ENST00000426395.3 ENST00000600273.1 ENST00000599988.1	FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr3_-_141747950	0.216	ENST00000497579.1	TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)
chrX_+_9431324	0.214	ENST00000407597.2 ENST00000424279.1 ENST00000536365.1 ENST00000441088.1 ENST00000380961.1 ENST00000415293.1	TBL1X	transducin (beta)-like 1X-linked
chr19_+_50016610	0.213	ENST00000596975.1	FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr17_-_39093672	0.192	ENST00000209718.3 ENST00000436344.3 ENST00000485751.1	KRT23	keratin 23 (histone deacetylase inducible)
chr11_+_27015628	0.187	ENST00000318627.2	FIBIN	fin bud initiation factor homolog (zebrafish)
chr11_-_63376013	0.178	ENST00000540943.1	PLA2G16	phospholipase A2, group XVI
chr19_-_49149553	0.172	ENST00000084798.4	CA11	carbonic anhydrase XI
chr2_+_26624775	0.171	ENST00000288710.2	DRC1	dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr18_+_72201664	0.161	ENST00000358821.3	CNDP1	carnosine dipeptidase 1 (metallopeptidase M20 family)
chr18_-_53303123	0.157	ENST00000569357.1 ENST00000565124.1 ENST00000398339.1	TCF4	transcription factor 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 17 of 17 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.5	GO:0010107	potassium ion import(GO:0010107)
0.1	0.4	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0	0.4	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.4	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.2	GO:0030242	pexophagy(GO:0030242)
0.0	0.2	GO:0019317	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.2	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0034239	macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0	0.1	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.0	0.1	GO:1901860	positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.0	0.1	GO:0034343	microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0	0.1	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:1901675	negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0	0.1	GO:0097068	response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)

Gene overrepresentation in cellular_component category:

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Showing 1 to 2 of 2 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0097224	sperm connecting piece(GO:0097224)
0.0	0.1	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)

Gene overrepresentation in molecular_function category:

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Showing 1 to 16 of 16 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0	0.5	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	0.4	GO:0019770	IgG receptor activity(GO:0019770)
0.1	0.4	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.3	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.2	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.2	GO:0008417	fucosyltransferase activity(GO:0008417)
0.0	0.2	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0	0.1	GO:0008808	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0	0.1	GO:0005477	pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0	0.1	GO:0050294	flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0	0.1	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004666	prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 3 of 3 entries

Total log-likelihood	Term	Description
0.5	REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4	REACTOME_ETHANOL_OXIDATION	Genes involved in Ethanol oxidation
0.1	REACTOME_ACYL_CHAIN_REMODELLING_OF_PG	Genes involved in Acyl chain remodelling of PG