Motif ID: LHX8

Z-value: 0.664


Transcription factors associated with LHX8:

Gene SymbolEntrez IDGene Name
LHX8 ENSG00000162624.10 LHX8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LHX8hg19_v2_chr1_+_75600567_75600567,
hg19_v2_chr1_+_75594119_75594119		-0.554.9e-03Click!


Activity profile for motif LHX8.

activity profile for motif LHX8


Sorted Z-values histogram for motif LHX8

Sorted Z-values for motif LHX8



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX8

PNG image of the network

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Top targets:


Showing 1 to 20 of 198 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_137028534 2.285 ENST00000348225.2
 PTN
pleiotrophin
chr7_-_137028498 2.118 ENST00000393083.2
 PTN
pleiotrophin
chr11_+_101918153 1.927 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr3_-_112693865 1.737 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
 CD200R1


CD200 receptor 1


chr12_-_71551652 1.713 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr22_-_50970919 1.679 ENST00000329363.4
ENST00000437588.1
 ODF3B

outer dense fiber of sperm tails 3B

chr4_-_110723134 1.545 ENST00000510800.1
ENST00000512148.1
 CFI

complement factor I

chr3_-_151102529 1.523 ENST00000302632.3
 P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_-_71551868 1.522 ENST00000247829.3
 TSPAN8
tetraspanin 8
chr4_-_110723194 1.482 ENST00000394635.3
 CFI
complement factor I
chr16_-_53737795 1.459 ENST00000262135.4
ENST00000564374.1
ENST00000566096.1
 RPGRIP1L


RPGRIP1-like


chr16_-_53737722 1.449 ENST00000569716.1
ENST00000562588.1
ENST00000562230.1
ENST00000379925.3
ENST00000563746.1
ENST00000568653.3
 RPGRIP1L





RPGRIP1-like





chr3_-_112693759 1.337 ENST00000440122.2
ENST00000490004.1
 CD200R1

CD200 receptor 1

chr4_-_110723335 1.336 ENST00000394634.2
 CFI
complement factor I
chr8_+_99076750 1.299 ENST00000545282.1
 C8orf47
chromosome 8 open reading frame 47
chr8_+_17354617 1.227 ENST00000470360.1
 SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr22_+_23487513 1.038 ENST00000263116.2
ENST00000341989.4
 RAB36

RAB36, member RAS oncogene family

chr8_+_99076509 1.015 ENST00000318528.3
 C8orf47
chromosome 8 open reading frame 47
chr5_-_75008244 0.951 ENST00000510798.1
ENST00000446329.2
 POC5

POC5 centriolar protein

chrX_-_117119243 0.881 ENST00000539496.1
ENST00000469946.1
 KLHL13

kelch-like family member 13


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.4 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 4.1 GO:0030449 regulation of complement activation(GO:0030449)
0.0 3.0 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 2.9 GO:0021670 lateral ventricle development(GO:0021670)
0.7 2.1 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.2 1.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 1.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 1.0 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.8 GO:0071305 cellular response to vitamin D(GO:0071305)
0.2 0.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720)
0.1 0.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.2 0.6 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.2 0.6 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 0.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 0.5 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.5 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.5 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0031594 neuromuscular junction(GO:0031594)
0.6 2.9 GO:0005879 axonemal microtubule(GO:0005879)
0.0 1.8 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.3 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.6 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 4.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 3.1 GO:0005178 integrin binding(GO:0005178)
1.0 2.9 GO:0031862 prostanoid receptor binding(GO:0031862)
0.5 2.1 GO:0005289 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.1 1.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 1.3 GO:0032027 myosin light chain binding(GO:0032027)
0.1 1.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 0.6 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 0.6 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 3.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.5 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation