Motif ID: LMX1B_MNX1_RAX2

Z-value: 0.590

Transcription factors associated with LMX1B_MNX1_RAX2:

Gene SymbolEntrez IDGene Name
LMX1B ENSG00000136944.13 LMX1B
MNX1 ENSG00000130675.10 MNX1
RAX2 ENSG00000173976.11 RAX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MNX1hg19_v2_chr7_-_156803329_156803362-0.405.4e-02Click!
RAX2hg19_v2_chr19_-_3772209_37722360.125.7e-01Click!
LMX1Bhg19_v2_chr9_+_129376722_129376748-0.067.8e-01Click!


Activity profile for motif LMX1B_MNX1_RAX2.

activity profile for motif LMX1B_MNX1_RAX2


Sorted Z-values histogram for motif LMX1B_MNX1_RAX2

Sorted Z-values for motif LMX1B_MNX1_RAX2



Network of associatons between targets according to the STRING database.



First level regulatory network of LMX1B_MNX1_RAX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_152386732 4.338 ENST00000271835.3
 CRNN
cornulin
chr4_+_69313145 2.538 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr12_-_28122980 1.730 ENST00000395868.3
ENST00000534890.1
 PTHLH

parathyroid hormone-like hormone

chr4_+_169013666 1.659 ENST00000359299.3
 ANXA10
annexin A10
chr7_+_134464376 1.498 ENST00000454108.1
ENST00000361675.2
 CALD1

caldesmon 1

chr2_+_158114051 1.488 ENST00000259056.4
 GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr5_+_31193847 1.447 ENST00000514738.1
ENST00000265071.2
 CDH6

cadherin 6, type 2, K-cadherin (fetal kidney)

chr12_-_28123206 1.443 ENST00000542963.1
ENST00000535992.1
 PTHLH

parathyroid hormone-like hormone

chr11_+_33061543 1.374 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1


t-complex 11, testis-specific-like 1


chr7_+_134464414 1.321 ENST00000361901.2
 CALD1
caldesmon 1
chr17_-_38859996 1.307 ENST00000264651.2
 KRT24
keratin 24
chr12_+_26348582 1.042 ENST00000535504.1
 SSPN
sarcospan
chr4_-_57547454 1.033 ENST00000556376.2
 HOPX
HOP homeobox
chr4_-_57547870 1.020 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
 HOPX



HOP homeobox



chr6_+_151646800 0.942 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chr15_+_93443419 0.941 ENST00000557381.1
ENST00000420239.2
 CHD2

chromodomain helicase DNA binding protein 2

chr17_-_64225508 0.920 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_107642348 0.904 ENST00000393561.1
 LAMB1
laminin, beta 1
chr12_-_89746173 0.887 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr4_+_169418255 0.887 ENST00000505667.1
ENST00000511948.1
 PALLD

palladin, cytoskeletal associated protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0009408 response to heat(GO:0009408)
0.1 3.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 3.1 GO:0070268 cornification(GO:0070268)
0.1 1.6 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 1.5 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.3 GO:0031424 keratinization(GO:0031424)
0.2 1.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 1.1 GO:0003334 keratinocyte development(GO:0003334)
0.1 1.0 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.3 0.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.9 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.2 0.8 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.8 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.8 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.8 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.7 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.7 GO:0019532 oxalate transport(GO:0019532)
0.0 0.6 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0030478 actin cap(GO:0030478)
0.0 2.0 GO:0045095 keratin filament(GO:0045095)
0.0 1.9 GO:0005882 intermediate filament(GO:0005882)
0.0 1.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 1.1 GO:0031523 Myb complex(GO:0031523)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.3 0.9 GO:0005607 laminin-2 complex(GO:0005607)
0.1 0.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 0.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 0.7 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.5 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 2.8 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 1.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.9 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.8 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 0.7 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.6 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.6 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.7 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.4 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions