Motif ID: MAFF_MAFG

Z-value: 1.281

Transcription factors associated with MAFF_MAFG:

Gene SymbolEntrez IDGene Name
MAFF ENSG00000185022.7 MAFF
MAFG ENSG00000197063.6 MAFG

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MAFFhg19_v2_chr22_+_38609538_38609547-0.546.3e-03Click!
MAFGhg19_v2_chr17_-_79885576_79885624-0.368.0e-02Click!


Activity profile for motif MAFF_MAFG.

activity profile for motif MAFF_MAFG


Sorted Z-values histogram for motif MAFF_MAFG

Sorted Z-values for motif MAFF_MAFG



Network of associatons between targets according to the STRING database.



First level regulatory network of MAFF_MAFG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_2709527 14.194 ENST00000250784.8
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr1_+_85527987 7.691 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
 WDR63


WD repeat domain 63


chr19_+_5914213 6.978 ENST00000222125.5
ENST00000452990.2
ENST00000588865.1
 CAPS


calcyphosine


chr12_+_111051902 6.265 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
 TCTN1



tectonic family member 1



chr5_-_54468974 5.605 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
 CDC20B




cell division cycle 20B




chrY_+_2709906 5.240 ENST00000430575.1
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr6_+_33043703 4.862 ENST00000418931.2
ENST00000535465.1
 HLA-DPB1

major histocompatibility complex, class II, DP beta 1

chr17_-_61512545 4.614 ENST00000585153.1
 CYB561
cytochrome b561
chr4_-_16077741 4.250 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
 PROM1


prominin 1


chr6_-_43478239 4.166 ENST00000372441.1
 LRRC73
leucine rich repeat containing 73
chr16_+_30211181 4.015 ENST00000395138.2
 SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr16_+_80574854 3.861 ENST00000305904.6
ENST00000568035.1
 DYNLRB2

dynein, light chain, roadblock-type 2

chr16_+_4838412 3.822 ENST00000589327.1
 SMIM22
small integral membrane protein 22
chr4_+_15480828 3.580 ENST00000389652.5
 CC2D2A
coiled-coil and C2 domain containing 2A
chr5_+_140019079 3.403 ENST00000252100.6
 TMCO6
transmembrane and coiled-coil domains 6
chr1_-_109655355 3.311 ENST00000369945.3
 C1orf194
chromosome 1 open reading frame 194
chr11_-_5248294 3.281 ENST00000335295.4
 HBB
hemoglobin, beta
chr1_-_109655377 3.182 ENST00000369948.3
 C1orf194
chromosome 1 open reading frame 194
chr2_+_120189422 3.168 ENST00000306406.4
 TMEM37
transmembrane protein 37
chr7_-_154863264 2.970 ENST00000395731.2
ENST00000543018.1
 HTR5A-AS1

HTR5A antisense RNA 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 10.6 GO:0007018 microtubule-based movement(GO:0007018)
1.4 9.8 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 6.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.3 6.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 5.8 GO:0022900 electron transport chain(GO:0022900)
0.1 4.9 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
1.1 4.2 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.6 4.0 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 4.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 3.7 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 3.7 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.0 3.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.8 3.3 GO:0030185 nitric oxide transport(GO:0030185)
0.0 2.8 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 2.7 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.9 2.6 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.6 2.5 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.2 2.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 2.2 GO:0030593 neutrophil chemotaxis(GO:0030593)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.2 GO:0005844 polysome(GO:0005844)
0.5 9.8 GO:0036038 MKS complex(GO:0036038)
0.1 8.8 GO:0030286 dynein complex(GO:0030286)
0.5 5.0 GO:0036157 outer dynein arm(GO:0036157)
0.2 4.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 3.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 3.5 GO:0032993 protein-DNA complex(GO:0032993)
0.8 3.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 2.9 GO:0005871 kinesin complex(GO:0005871)
0.4 2.6 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.2 2.5 GO:0097433 dense body(GO:0097433)
0.1 2.5 GO:0097225 sperm midpiece(GO:0097225)
0.3 2.4 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 1.7 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 1.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.5 GO:0019843 rRNA binding(GO:0019843)
0.3 7.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.7 5.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 5.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 5.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 4.8 GO:0042605 peptide antigen binding(GO:0042605)
1.2 4.6 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 4.1 GO:0003777 microtubule motor activity(GO:0003777)
0.7 4.0 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.3 4.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.3 3.8 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.0 3.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.9 GO:0005262 calcium channel activity(GO:0005262)
0.3 2.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 2.6 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.6 2.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 2.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 2.1 GO:0019894 kinesin binding(GO:0019894)
0.7 2.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 4.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 0.9 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.8 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.7 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.0 PID_TRAIL_PATHWAY TRAIL signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.2 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 5.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 4.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 4.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 3.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.1 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 1.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.9 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.9 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 0.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases