Motif ID: MAX_TFEB

Z-value: 0.643

Transcription factors associated with MAX_TFEB:

Gene SymbolEntrez IDGene Name
MAX ENSG00000125952.14 MAX
TFEB ENSG00000112561.13 TFEB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFEBhg19_v2_chr6_-_41701581_41701613-0.193.8e-01Click!
MAXhg19_v2_chr14_-_65569244_655694130.106.5e-01Click!


Activity profile for motif MAX_TFEB.

activity profile for motif MAX_TFEB


Sorted Z-values histogram for motif MAX_TFEB

Sorted Z-values for motif MAX_TFEB



Network of associatons between targets according to the STRING database.



First level regulatory network of MAX_TFEB

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_7137582 1.381 ENST00000575756.1
ENST00000575458.1
 DVL2

dishevelled segment polarity protein 2

chr12_+_50355647 1.347 ENST00000293599.6
 AQP5
aquaporin 5
chr9_-_124976185 0.936 ENST00000464484.2
 LHX6
LIM homeobox 6
chr17_-_7137857 0.854 ENST00000005340.5
 DVL2
dishevelled segment polarity protein 2
chr9_-_124976154 0.746 ENST00000482062.1
 LHX6
LIM homeobox 6
chr7_+_116593568 0.723 ENST00000446490.1
 ST7
suppression of tumorigenicity 7
chrX_-_34675391 0.709 ENST00000275954.3
 TMEM47
transmembrane protein 47
chr7_+_116593433 0.659 ENST00000323984.3
ENST00000393449.1
 ST7

suppression of tumorigenicity 7

chr5_+_133706865 0.657 ENST00000265339.2
 UBE2B
ubiquitin-conjugating enzyme E2B
chr2_-_133427767 0.624 ENST00000397463.2
 LYPD1
LY6/PLAUR domain containing 1
chr19_-_10764509 0.580 ENST00000591501.1
 ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr1_-_207119738 0.580 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr5_-_121413974 0.577 ENST00000231004.4
 LOX
lysyl oxidase
chr6_+_123110465 0.563 ENST00000539041.1
 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr6_-_80657292 0.545 ENST00000369816.4
 ELOVL4
ELOVL fatty acid elongase 4
chr3_-_19988462 0.531 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr6_+_123110302 0.523 ENST00000368440.4
 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr7_+_155090271 0.520 ENST00000476756.1
 INSIG1
insulin induced gene 1
chr7_+_106685079 0.517 ENST00000265717.4
 PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr1_-_154193009 0.500 ENST00000368518.1
ENST00000368519.1
ENST00000368521.5
 C1orf43


chromosome 1 open reading frame 43



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.2 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 1.7 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 1.3 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 1.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 1.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.1 1.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.0 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.3 0.9 GO:1904170 regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.3 0.8 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.8 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.1 0.8 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.8 GO:2000810 regulation of bicellular tight junction assembly(GO:2000810)
0.0 0.8 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 0.7 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.7 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.1 0.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 0.9 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 0.9 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.9 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.8 GO:0033503 HULC complex(GO:0033503)
0.1 0.8 GO:0070552 BRISC complex(GO:0070552)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.6 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.5 GO:0002177 manchette(GO:0002177)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.1 1.3 GO:0015250 water channel activity(GO:0015250)
0.0 1.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 1.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.8 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 0.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.6 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 0.5 GO:0004370 glycerol kinase activity(GO:0004370)
0.2 0.5 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.5 GO:0043398 HLH domain binding(GO:0043398)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.6 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.2 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade