Motif ID: MAZ_ZNF281_GTF2F1

Z-value: 1.630

Transcription factors associated with MAZ_ZNF281_GTF2F1:

Gene SymbolEntrez IDGene Name
GTF2F1 ENSG00000125651.9 GTF2F1
MAZ ENSG00000103495.9 MAZ
ZNF281 ENSG00000162702.7 ZNF281

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MAZhg19_v2_chr16_+_29817841_298179170.321.3e-01Click!
GTF2F1hg19_v2_chr19_-_6393216_63932290.184.1e-01Click!
ZNF281hg19_v2_chr1_-_200379180_200379191-0.145.1e-01Click!


Activity profile for motif MAZ_ZNF281_GTF2F1.

activity profile for motif MAZ_ZNF281_GTF2F1


Sorted Z-values histogram for motif MAZ_ZNF281_GTF2F1

Sorted Z-values for motif MAZ_ZNF281_GTF2F1



Network of associatons between targets according to the STRING database.



First level regulatory network of MAZ_ZNF281_GTF2F1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471381 3.590 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr1_-_205419053 3.353 ENST00000367154.1
 LEMD1
LEM domain containing 1
chr19_-_51471362 3.259 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_+_35645618 3.236 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr19_-_51487071 3.160 ENST00000391807.1
ENST00000593904.1
 KLK7

kallikrein-related peptidase 7

chr14_+_24540731 3.094 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
 CPNE6




copine VI (neuronal)




chr19_-_49015050 3.080 ENST00000600059.1
 LMTK3
lemur tyrosine kinase 3
chr19_-_42573650 3.012 ENST00000593562.1
 GRIK5
glutamate receptor, ionotropic, kainate 5
chr1_-_20812690 2.909 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_+_35645817 2.852 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr17_+_70117153 2.821 ENST00000245479.2
 SOX9
SRY (sex determining region Y)-box 9
chr12_+_4382917 2.793 ENST00000261254.3
 CCND2
cyclin D2
chr19_-_51456344 2.694 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr7_-_41740181 2.689 ENST00000442711.1
 INHBA
inhibin, beta A
chr20_-_62103862 2.426 ENST00000344462.4
ENST00000357249.2
ENST00000359125.2
ENST00000360480.3
ENST00000370224.1
ENST00000344425.5
ENST00000354587.3
ENST00000359689.1
 KCNQ2







potassium voltage-gated channel, KQT-like subfamily, member 2







chr2_-_216300784 2.411 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr1_+_211432700 2.303 ENST00000452621.2
 RCOR3
REST corepressor 3
chr19_-_51456321 2.279 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr2_+_79740118 2.206 ENST00000496558.1
ENST00000451966.1
 CTNNA2

catenin (cadherin-associated protein), alpha 2

chr19_-_51487282 2.182 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
 KLK7


kallikrein-related peptidase 7



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,203 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 12.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.5 11.2 GO:0016540 protein autoprocessing(GO:0016540)
0.1 8.7 GO:0030574 collagen catabolic process(GO:0030574)
0.2 7.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.3 7.4 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 6.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.0 6.0 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.7 6.0 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.5 4.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 4.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.2 4.1 GO:0001502 cartilage condensation(GO:0001502)
0.8 4.0 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 4.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.5 3.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 3.7 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.3 3.7 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.3 3.6 GO:0034465 response to carbon monoxide(GO:0034465)
0.2 3.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 3.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.4 3.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 369 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.5 GO:0005615 extracellular space(GO:0005615)
1.8 12.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 10.5 GO:0009986 cell surface(GO:0009986)
0.1 10.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 8.8 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 7.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 7.0 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.2 6.2 GO:0030673 axolemma(GO:0030673)
0.3 6.1 GO:0005861 troponin complex(GO:0005861)
0.0 5.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 5.6 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 5.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 5.2 GO:0002102 podosome(GO:0002102)
0.1 5.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 4.6 GO:0043197 dendritic spine(GO:0043197)
0.7 4.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 4.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 4.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.3 3.9 GO:0097512 cardiac myofibril(GO:0097512)
0.0 3.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 662 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 24.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 8.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 7.8 GO:0005096 GTPase activator activity(GO:0005096)
0.5 6.8 GO:0031014 troponin T binding(GO:0031014)
0.0 5.8 GO:0005178 integrin binding(GO:0005178)
0.1 5.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 5.1 GO:0051015 actin filament binding(GO:0051015)
0.1 4.7 GO:0030506 ankyrin binding(GO:0030506)
0.5 4.4 GO:0043426 MRF binding(GO:0043426)
0.3 4.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.5 4.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 4.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.2 4.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 4.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 4.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 4.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 3.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 3.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 3.7 GO:0005212 structural constituent of eye lens(GO:0005212)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 16.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 13.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 10.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 9.1 NABA_COLLAGENS Genes encoding collagen proteins
0.2 9.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 4.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 4.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 4.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.7 PID_INSULIN_PATHWAY Insulin Pathway
0.2 3.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.4 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 3.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 11.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 10.9 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 9.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 7.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 5.4 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 5.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 5.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 5.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 4.8 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 4.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 3.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 3.6 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 3.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.1 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 3.1 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 2.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 2.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB