Motif ID: MBD2

Z-value: 0.596


Transcription factors associated with MBD2:

Gene SymbolEntrez IDGene Name
MBD2 ENSG00000134046.7 MBD2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MBD2hg19_v2_chr18_-_51751132_517511580.106.4e-01Click!


Activity profile for motif MBD2.

activity profile for motif MBD2


Sorted Z-values histogram for motif MBD2

Sorted Z-values for motif MBD2



Network of associatons between targets according to the STRING database.



First level regulatory network of MBD2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_17659234 0.661 ENST00000466335.1
 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr20_-_56284816 0.569 ENST00000395819.3
ENST00000341744.3
 PMEPA1

prostate transmembrane protein, androgen induced 1

chr19_+_18496957 0.552 ENST00000252809.3
 GDF15
growth differentiation factor 15
chr6_-_43596899 0.419 ENST00000307126.5
ENST00000452781.1
 GTPBP2

GTP binding protein 2

chr19_+_39904168 0.408 ENST00000438123.1
ENST00000409797.2
ENST00000451354.2
 PLEKHG2


pleckstrin homology domain containing, family G (with RhoGef domain) member 2


chr19_-_19051103 0.346 ENST00000542541.2
ENST00000433218.2
 HOMER3

homer homolog 3 (Drosophila)

chr17_-_27278445 0.344 ENST00000268756.3
ENST00000584685.1
 PHF12

PHD finger protein 12

chrX_+_68725084 0.321 ENST00000252338.4
 FAM155B
family with sequence similarity 155, member B
chr19_+_56152262 0.320 ENST00000325333.5
ENST00000590190.1
 ZNF580

zinc finger protein 580

chr5_+_153570285 0.318 ENST00000425427.2
ENST00000297107.6
 GALNT10

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)

chr19_+_35491174 0.309 ENST00000317991.5
ENST00000504615.2
 GRAMD1A

GRAM domain containing 1A

chr12_+_122064673 0.302 ENST00000537188.1
 ORAI1
ORAI calcium release-activated calcium modulator 1
chr2_-_129076151 0.288 ENST00000259241.6
 HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr5_+_153570319 0.286 ENST00000377661.2
 GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr5_-_72744336 0.284 ENST00000499003.3
 FOXD1
forkhead box D1
chr14_+_74417192 0.279 ENST00000554320.1
 COQ6
coenzyme Q6 monooxygenase
chr1_-_43232649 0.277 ENST00000372526.2
ENST00000236040.4
ENST00000296388.5
ENST00000397054.3
 LEPRE1



leucine proline-enriched proteoglycan (leprecan) 1



chr3_+_88108381 0.269 ENST00000473136.1
 RP11-159G9.5
Uncharacterized protein
chr3_-_196295437 0.269 ENST00000429115.1
 WDR53
WD repeat domain 53
chr17_+_17942684 0.269 ENST00000376345.3
 GID4
GID complex subunit 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.6 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.6 GO:0060117 auditory receptor cell development(GO:0060117)
0.1 0.4 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.3 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.1 0.3 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.3 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.3 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.3 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.3 GO:0031643 positive regulation of myelination(GO:0031643)
0.1 0.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.3 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.0 0.2 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0097413 Lewy body(GO:0097413)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.3 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.3 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.3 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0071949 FAD binding(GO:0071949)
0.1 0.2 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.2 GO:0032427 GBD domain binding(GO:0032427)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.2 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins