Motif ID: MECP2

Z-value: 1.958


Transcription factors associated with MECP2:

Gene SymbolEntrez IDGene Name
MECP2 ENSG00000169057.15 MECP2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MECP2hg19_v2_chrX_-_153363125_1533631820.252.3e-01Click!


Activity profile for motif MECP2.

activity profile for motif MECP2


Sorted Z-values histogram for motif MECP2

Sorted Z-values for motif MECP2



Network of associatons between targets according to the STRING database.



First level regulatory network of MECP2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_33877654 6.024 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3



formin homology 2 domain containing 3



chr19_-_51471362 5.476 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51471381 5.261 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr13_-_20806440 5.088 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6


gap junction protein, beta 6, 30kDa


chr1_-_17307173 4.413 ENST00000438542.1
ENST00000375535.3
 MFAP2

microfibrillar-associated protein 2

chr19_-_51472222 4.268 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr17_+_70117153 4.132 ENST00000245479.2
 SOX9
SRY (sex determining region Y)-box 9
chr21_-_44496441 4.026 ENST00000359624.3
ENST00000352178.5
 CBS

cystathionine-beta-synthase

chr19_-_51472031 3.988 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr1_+_150522222 3.943 ENST00000369039.5
 ADAMTSL4
ADAMTS-like 4
chr2_+_23608064 3.807 ENST00000486442.1
 KLHL29
kelch-like family member 29
chr1_-_6545502 3.716 ENST00000535355.1
 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr20_-_56284816 3.687 ENST00000395819.3
ENST00000341744.3
 PMEPA1

prostate transmembrane protein, androgen induced 1

chr2_-_224903995 3.502 ENST00000409304.1
ENST00000454956.1
ENST00000258405.4
 SERPINE2


serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2


chr18_-_28681950 3.402 ENST00000251081.6
 DSC2
desmocollin 2
chr9_+_131182697 3.357 ENST00000372838.4
ENST00000411852.1
 CERCAM

cerebral endothelial cell adhesion molecule

chr12_-_47473642 3.352 ENST00000266581.4
 AMIGO2
adhesion molecule with Ig-like domain 2
chr2_-_31360887 3.348 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
 GALNT14


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)


chr8_+_86376081 3.297 ENST00000285379.5
 CA2
carbonic anhydrase II
chr2_-_235405679 3.284 ENST00000390645.2
 ARL4C
ADP-ribosylation factor-like 4C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,405 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 22.5 GO:0016540 protein autoprocessing(GO:0016540)
0.1 10.0 GO:0070126 mitochondrial translational termination(GO:0070126)
0.4 9.9 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.2 9.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
2.5 7.6 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.1 7.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.4 6.7 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.3 6.7 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.4 6.4 GO:0051639 actin filament network formation(GO:0051639)
1.0 6.2 GO:0030421 defecation(GO:0030421)
0.4 6.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 6.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.2 6.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
2.0 5.9 GO:0046521 sphingoid catabolic process(GO:0046521)
0.7 5.9 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.4 5.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 5.9 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
1.4 5.8 GO:0006218 uridine catabolic process(GO:0006218)
0.1 5.7 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.5 5.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 459 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 54.2 GO:0005730 nucleolus(GO:0005730)
0.1 38.5 GO:0005925 focal adhesion(GO:0005925)
0.1 13.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 12.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 11.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.5 10.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 9.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 9.1 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 9.1 GO:0009986 cell surface(GO:0009986)
0.0 8.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 8.5 GO:0005811 lipid particle(GO:0005811)
0.0 8.3 GO:0019867 outer membrane(GO:0019867)
0.3 7.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 7.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 7.7 GO:0005922 connexon complex(GO:0005922)
0.1 7.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 7.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 7.1 GO:0030027 lamellipodium(GO:0030027)
0.2 7.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 6.7 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 765 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 17.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 16.2 GO:0045296 cadherin binding(GO:0045296)
0.0 15.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 14.7 GO:0002020 protease binding(GO:0002020)
0.1 12.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 11.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 11.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.6 10.0 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 9.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 8.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 8.1 GO:0061650 ubiquitin-like protein conjugating enzyme activity(GO:0061650)
2.5 7.6 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.3 6.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 6.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.5 6.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.3 6.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 6.0 GO:0001618 virus receptor activity(GO:0001618)
1.0 5.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 5.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 24.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.2 14.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 14.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 12.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 10.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 10.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 9.6 PID_E2F_PATHWAY E2F transcription factor network
0.3 9.0 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 8.8 PID_LKB1_PATHWAY LKB1 signaling events
0.1 8.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.3 8.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.2 7.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.2 7.5 PID_IGF1_PATHWAY IGF1 pathway
0.1 7.4 PID_CDC42_PATHWAY CDC42 signaling events
0.1 6.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 5.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 5.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 5.0 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 4.9 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 20.1 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.2 14.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 14.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 14.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.4 10.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 9.7 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.2 9.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 7.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.3 7.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 7.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.2 7.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 7.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 6.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 6.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 6.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 6.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 6.1 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 6.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 6.0 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling