Motif ID: MEF2B
Z-value: 0.745
Transcription factors associated with MEF2B:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| MEF2B | ENSG00000213999.11 | MEF2B |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2B | hg19_v2_chr19_-_19302931_19302974 | 0.16 | 4.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.2 | 0.9 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.2 | 0.5 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.2 | 0.5 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.2 | 0.5 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.1 | 1.2 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.1 | 0.5 | GO:0032972 | diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972) |
| 0.1 | 0.4 | GO:0071288 | cellular response to mercury ion(GO:0071288) |
| 0.1 | 0.3 | GO:0050894 | determination of affect(GO:0050894) |
| 0.1 | 0.8 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.1 | 0.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.1 | 0.5 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.1 | 0.4 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.2 | GO:0015862 | uridine transport(GO:0015862) |
| 0.0 | 0.3 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) ERK5 cascade(GO:0070375) |
| 0.0 | 0.9 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.0 | 0.5 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.0 | 0.2 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.0 | 0.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.1 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.0 | 0.2 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.0 | 0.6 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.2 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.0 | 0.7 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.0 | 0.3 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 1.2 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 0.0 | 0.1 | GO:0060023 | soft palate development(GO:0060023) |
| 0.0 | 0.1 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883) |
| 0.0 | 0.1 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.0 | 0.3 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.0 | 0.2 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 1.8 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 2.1 | GO:0061045 | negative regulation of wound healing(GO:0061045) |
| 0.0 | 0.1 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598) |
| 0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.8 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 0.2 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.0 | 0.0 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.0 | 0.4 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.4 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.0 | 0.1 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.0 | 0.1 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.0 | 0.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.0 | 0.0 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.5 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 0.5 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.1 | 0.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 1.6 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.4 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.1 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 0.5 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.2 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 0.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 0.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.1 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.0 | 0.4 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.1 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 0.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.2 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.5 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.7 | GO:0014704 | intercalated disc(GO:0014704) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.2 | 0.5 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 0.7 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.1 | 0.3 | GO:0031877 | somatostatin receptor binding(GO:0031877) |
| 0.1 | 0.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 0.3 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.1 | 0.9 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 0.5 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.1 | 1.6 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 0.3 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.1 | 0.8 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 0.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.1 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.0 | 0.2 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 0.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.3 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 0.3 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 1.2 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.2 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.0 | 0.6 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 0.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 2.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.1 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.0 | 0.5 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.5 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.1 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.0 | 0.1 | GO:0042835 | BRE binding(GO:0042835) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.0 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.5 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.5 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
