Motif ID: MEF2B

Z-value: 0.745


Transcription factors associated with MEF2B:

Gene SymbolEntrez IDGene Name
MEF2B ENSG00000213999.11 MEF2B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MEF2Bhg19_v2_chr19_-_19302931_193029740.164.6e-01Click!


Activity profile for motif MEF2B.

activity profile for motif MEF2B


Sorted Z-values histogram for motif MEF2B

Sorted Z-values for motif MEF2B



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2B

PNG image of the network

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Top targets:


Showing 1 to 20 of 145 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_131200810 1.810 ENST00000536002.1
ENST00000544034.1
RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr2_+_233497931 1.179 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr16_+_84328252 1.056 ENST00000219454.5
WFDC1
WAP four-disulfide core domain 1
chr16_+_84328429 1.048 ENST00000568638.1
WFDC1
WAP four-disulfide core domain 1
chr2_-_86564776 0.857 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1


receptor accessory protein 1


chr8_+_1993173 0.809 ENST00000523438.1
MYOM2
myomesin 2
chr12_-_111358372 0.805 ENST00000548438.1
ENST00000228841.8
MYL2

myosin, light chain 2, regulatory, cardiac, slow

chr8_-_27115931 0.804 ENST00000523048.1
STMN4
stathmin-like 4
chrX_-_63450480 0.803 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr8_+_1993152 0.802 ENST00000262113.4
MYOM2
myomesin 2
chr18_+_12407895 0.763 ENST00000590956.1
ENST00000336990.4
ENST00000440960.1
ENST00000588729.1
SLMO1



slowmo homolog 1 (Drosophila)



chr17_-_39211463 0.707 ENST00000542910.1
ENST00000398477.1
KRTAP2-2

keratin associated protein 2-2

chr4_+_120056939 0.670 ENST00000307128.5
MYOZ2
myozenin 2
chr8_-_72268889 0.617 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chr8_-_72268968 0.609 ENST00000388740.3
EYA1
eyes absent homolog 1 (Drosophila)
chr17_+_42248063 0.603 ENST00000293414.1
ASB16
ankyrin repeat and SOCS box containing 16
chr6_+_123038689 0.603 ENST00000354275.2
ENST00000368446.1
PKIB

protein kinase (cAMP-dependent, catalytic) inhibitor beta

chr11_-_84634217 0.582 ENST00000524982.1
DLG2
discs, large homolog 2 (Drosophila)
chr4_+_8321882 0.576 ENST00000503186.1
ENST00000509453.1
RP11-774O3.1
RP11-774O3.2
RP11-774O3.1
RP11-774O3.2
chr11_-_84634447 0.573 ENST00000532653.1
DLG2
discs, large homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0061045 negative regulation of wound healing(GO:0061045)
0.2 1.9 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 1.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 1.2 GO:0046710 GDP metabolic process(GO:0046710)
0.2 0.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.7 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 0.5 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.2 0.5 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.2 0.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.5 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.1 0.5 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.5 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.1 0.4 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 0.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0032982 myosin filament(GO:0032982)
0.0 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.8 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.7 GO:0014704 intercalated disc(GO:0014704)
0.2 0.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0097546 ciliary base(GO:0097546)
0.0 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.4 GO:0005861 troponin complex(GO:0005861)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 0.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.8 GO:0031014 troponin T binding(GO:0031014)
0.1 0.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:0051373 FATZ binding(GO:0051373)
0.0 0.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.5 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.5 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.3 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.3 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs