Motif ID: MEF2D_MEF2A

Z-value: 0.629

Transcription factors associated with MEF2D_MEF2A:

Gene SymbolEntrez IDGene Name
MEF2A ENSG00000068305.13 MEF2A
MEF2D ENSG00000116604.13 MEF2D

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MEF2Ahg19_v2_chr15_+_100106155_100106243-0.291.7e-01Click!
MEF2Dhg19_v2_chr1_-_156460391_1564604170.174.3e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2D_MEF2A

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_131200810 1.324 ENST00000536002.1
ENST00000544034.1
RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr2_+_233497931 0.827 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr1_-_201391149 0.823 ENST00000555948.1
ENST00000556362.1
TNNI1

troponin I type 1 (skeletal, slow)

chr7_-_113559104 0.795 ENST00000284601.3
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr14_+_24540731 0.731 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
CPNE6




copine VI (neuronal)




chr3_-_108248169 0.651 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr3_+_35683651 0.617 ENST00000187397.4
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_-_121944491 0.576 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr17_+_37821593 0.568 ENST00000578283.1
TCAP
titin-cap
chr4_-_23891658 0.529 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr17_+_7184986 0.510 ENST00000317370.8
ENST00000571308.1
SLC2A4

solute carrier family 2 (facilitated glucose transporter), member 4

chr9_-_104145795 0.488 ENST00000259407.2
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr11_-_19223523 0.476 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr17_+_34538310 0.450 ENST00000444414.1
ENST00000378350.4
ENST00000389068.5
ENST00000588929.1
ENST00000589079.1
ENST00000589336.1
ENST00000400702.4
ENST00000591167.1
ENST00000586598.1
ENST00000591637.1
ENST00000378352.4
ENST00000358756.5
CCL4L1











chemokine (C-C motif) ligand 4-like 1











chr3_+_138067666 0.435 ENST00000475711.1
ENST00000464896.1
MRAS

muscle RAS oncogene homolog

chr1_-_25756638 0.423 ENST00000349320.3
RHCE
Rh blood group, CcEe antigens
chr17_-_72855989 0.419 ENST00000293190.5
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr11_+_129245796 0.413 ENST00000281437.4
BARX2
BARX homeobox 2
chr2_-_211168332 0.401 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr3_+_138067314 0.398 ENST00000423968.2
MRAS
muscle RAS oncogene homolog

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 1.0 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 0.9 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.7 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 0.5 GO:0019530 taurine metabolic process(GO:0019530)
0.0 0.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 0.4 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.4 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.0 0.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.4 GO:0090050 peptidyl-lysine deacetylation(GO:0034983) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.4 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.4 GO:0015695 organic cation transport(GO:0015695)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.0 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.3 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0005861 troponin complex(GO:0005861)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0097440 apical dendrite(GO:0097440)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.0 0.3 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.3 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.2 GO:0042022 interleukin-12 receptor complex(GO:0042022)
0.1 0.2 GO:0031674 I band(GO:0031674)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 0.8 GO:0051373 FATZ binding(GO:0051373)
0.0 0.7 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 0.6 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.5 GO:0031433 telethonin binding(GO:0031433)
0.0 0.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.3 GO:0042835 BRE binding(GO:0042835)
0.0 0.3 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.3 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol