Motif ID: MEIS2

Z-value: 1.179


Transcription factors associated with MEIS2:

Gene SymbolEntrez IDGene Name
MEIS2 ENSG00000134138.15 MEIS2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MEIS2hg19_v2_chr15_-_37391614_37391683-0.048.6e-01Click!


Activity profile for motif MEIS2.

activity profile for motif MEIS2


Sorted Z-values histogram for motif MEIS2

Sorted Z-values for motif MEIS2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEIS2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_65769392 5.160 ENST00000555736.1
 CTD-2509G16.5
CTD-2509G16.5
chr1_+_78956651 4.018 ENST00000370757.3
ENST00000370756.3
 PTGFR

prostaglandin F receptor (FP)

chr19_-_9092018 3.975 ENST00000397910.4
 MUC16
mucin 16, cell surface associated
chr1_-_152131703 3.931 ENST00000316073.3
 RPTN
repetin
chr6_+_32407619 3.868 ENST00000395388.2
ENST00000374982.5
 HLA-DRA

major histocompatibility complex, class II, DR alpha

chr3_+_13610216 3.428 ENST00000492059.1
 FBLN2
fibulin 2
chr6_-_32498046 3.408 ENST00000374975.3
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr3_+_63638339 3.369 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr5_-_35938674 3.139 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr6_-_33048483 3.054 ENST00000419277.1
 HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr4_+_69962185 2.792 ENST00000305231.7
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr9_-_34381536 2.711 ENST00000379126.3
ENST00000379127.1
ENST00000379133.3
 C9orf24


chromosome 9 open reading frame 24


chr14_-_107078851 2.670 ENST00000390628.2
 IGHV1-58
immunoglobulin heavy variable 1-58
chr4_+_69962212 2.608 ENST00000508661.1
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr12_+_109826524 2.585 ENST00000431443.2
 MYO1H
myosin IH
chr4_-_149365827 2.430 ENST00000344721.4
 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr19_-_9003586 2.381 ENST00000380951.5
 MUC16
mucin 16, cell surface associated
chr11_+_27062272 2.336 ENST00000529202.1
ENST00000533566.1
 BBOX1

butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1

chr11_+_27062860 2.120 ENST00000528583.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr20_+_31870927 2.097 ENST00000253354.1
 BPIFB1
BPI fold containing family B, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 733 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0031295 T cell costimulation(GO:0031295)
0.0 8.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 8.0 GO:0016266 O-glycan processing(GO:0016266)
0.6 6.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 6.0 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 6.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
1.3 5.0 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 5.0 GO:0090383 phagosome acidification(GO:0090383)
0.1 4.6 GO:0035082 axoneme assembly(GO:0035082)
0.2 4.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 4.0 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.4 3.9 GO:0006824 cobalt ion transport(GO:0006824)
0.4 3.5 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 3.0 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 3.0 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.3 2.9 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.4 2.8 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.9 2.7 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.1 2.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 2.7 GO:0034198 cellular response to amino acid starvation(GO:0034198)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 19.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 11.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 4.7 GO:0043202 lysosomal lumen(GO:0043202)
0.2 4.4 GO:0097512 cardiac myofibril(GO:0097512)
0.3 3.5 GO:0072687 meiotic spindle(GO:0072687)
0.1 3.5 GO:0030286 dynein complex(GO:0030286)
0.1 3.3 GO:0031012 extracellular matrix(GO:0031012)
0.2 3.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.7 GO:0036038 MKS complex(GO:0036038)
0.0 2.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.3 GO:0036126 sperm flagellum(GO:0036126)
0.0 2.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.9 GO:0097542 ciliary tip(GO:0097542)
0.0 1.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 476 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 8.2 GO:0042605 peptide antigen binding(GO:0042605)
1.7 6.8 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 5.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 5.0 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 5.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 4.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 4.1 GO:0005212 structural constituent of eye lens(GO:0005212)
1.3 3.9 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.2 3.9 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 3.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 3.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 3.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.3 3.1 GO:0031419 cobalamin binding(GO:0031419)
0.2 2.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 2.6 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.3 2.5 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.1 2.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 2.5 GO:0002020 protease binding(GO:0002020)
0.1 2.4 GO:0004017 adenylate kinase activity(GO:0004017)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.8 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 4.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 3.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 3.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.0 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 ST_ADRENERGIC Adrenergic Pathway
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4 10.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 8.8 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.3 6.7 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 4.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 4.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 4.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.4 4.3 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 4.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.9 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 3.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 3.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 2.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 2.7 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 2.7 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 2.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)