Motif ID: MEIS3_TGIF2LX

Z-value: 0.419

Transcription factors associated with MEIS3_TGIF2LX:

Gene SymbolEntrez IDGene Name
MEIS3 ENSG00000105419.13 MEIS3
TGIF2LX ENSG00000153779.8 TGIF2LX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TGIF2LXhg19_v2_chrX_+_89176881_89176955-0.203.4e-01Click!
MEIS3hg19_v2_chr19_-_47922750_47922795-0.048.5e-01Click!


Activity profile for motif MEIS3_TGIF2LX.

activity profile for motif MEIS3_TGIF2LX


Sorted Z-values histogram for motif MEIS3_TGIF2LX

Sorted Z-values for motif MEIS3_TGIF2LX



Network of associatons between targets according to the STRING database.



First level regulatory network of MEIS3_TGIF2LX

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_32557610 0.997 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr11_+_86511549 0.818 ENST00000533902.2
 PRSS23
protease, serine, 23
chr19_+_17982747 0.688 ENST00000222248.3
 SLC5A5
solute carrier family 5 (sodium/iodide cotransporter), member 5
chr1_-_47655686 0.662 ENST00000294338.2
 PDZK1IP1
PDZK1 interacting protein 1
chr19_-_9092018 0.542 ENST00000397910.4
 MUC16
mucin 16, cell surface associated
chr1_+_79115503 0.499 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44


interferon-induced protein 44


chr3_-_122512619 0.495 ENST00000383659.1
ENST00000306103.2
 HSPBAP1

HSPB (heat shock 27kDa) associated protein 1

chr11_+_827553 0.390 ENST00000528542.2
ENST00000450448.1
 EFCAB4A

EF-hand calcium binding domain 4A

chr16_+_30212378 0.384 ENST00000569485.1
 SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr6_+_24495067 0.362 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
 ALDH5A1


aldehyde dehydrogenase 5 family, member A1


chr2_-_73460334 0.348 ENST00000258083.2
 PRADC1
protease-associated domain containing 1
chr6_-_52860171 0.324 ENST00000370963.4
 GSTA4
glutathione S-transferase alpha 4
chr13_+_96085847 0.322 ENST00000376873.3
 CLDN10
claudin 10
chr16_+_1306060 0.309 ENST00000397534.2
 TPSD1
tryptase delta 1
chr17_+_48172639 0.303 ENST00000503176.1
ENST00000503614.1
 PDK2

pyruvate dehydrogenase kinase, isozyme 2

chr16_+_69458428 0.299 ENST00000512062.1
ENST00000307892.8
 CYB5B

cytochrome b5 type B (outer mitochondrial membrane)

chr19_-_45826125 0.277 ENST00000221476.3
 CKM
creatine kinase, muscle
chr3_-_3221358 0.276 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
 CRBN



cereblon



chr11_-_82745238 0.271 ENST00000531021.1
 RAB30
RAB30, member RAS oncogene family
chr12_-_81763127 0.263 ENST00000541017.1
 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.0 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.1 0.7 GO:0015705 iodide transport(GO:0015705)
0.0 0.5 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.0 0.5 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 0.4 GO:0009450 acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.1 0.4 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1 0.3 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 0.3 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.3 GO:0032306 regulation of prostaglandin secretion(GO:0032306) positive regulation of prostaglandin secretion(GO:0032308)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.3 GO:0050812 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.2 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.1 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.2 GO:0009233 menaquinone metabolic process(GO:0009233)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.1 GO:1903517 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.2 GO:0055087 Ski complex(GO:0055087)
0.0 0.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0043196 varicosity(GO:0043196)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 0.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 0.4 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.1 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.2 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha