Motif ID: MESP1

Z-value: 1.109


Transcription factors associated with MESP1:

Gene SymbolEntrez IDGene Name
MESP1 ENSG00000166823.5 MESP1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MESP1hg19_v2_chr15_-_90294523_90294541-0.183.9e-01Click!


Activity profile for motif MESP1.

activity profile for motif MESP1


Sorted Z-values histogram for motif MESP1

Sorted Z-values for motif MESP1



Network of associatons between targets according to the STRING database.



First level regulatory network of MESP1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_167098059 4.995 ENST00000392764.1
ENST00000474464.1
ENST00000392766.2
ENST00000485651.1
 ZBBX



zinc finger, B-box domain containing



chr4_-_16085340 4.983 ENST00000508167.1
 PROM1
prominin 1
chr4_-_16085314 4.964 ENST00000510224.1
 PROM1
prominin 1
chr11_+_73358594 4.254 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
 PLEKHB1


pleckstrin homology domain containing, family B (evectins) member 1


chr3_+_63638339 3.906 ENST00000343837.3
ENST00000469440.1
 SNTN

sentan, cilia apical structure protein

chr20_+_56725952 2.978 ENST00000371168.3
 C20orf85
chromosome 20 open reading frame 85
chr1_-_46089718 2.957 ENST00000421127.2
ENST00000343901.2
ENST00000528266.1
 CCDC17


coiled-coil domain containing 17


chr16_-_776431 2.886 ENST00000293889.6
 CCDC78
coiled-coil domain containing 78
chr3_-_50383096 2.790 ENST00000442887.1
ENST00000360165.3
 ZMYND10

zinc finger, MYND-type containing 10

chr10_+_22634384 2.777 ENST00000376624.3
ENST00000376603.2
ENST00000376601.1
ENST00000538630.1
ENST00000456231.2
ENST00000313311.6
ENST00000435326.1
 SPAG6






sperm associated antigen 6






chr17_+_4981535 2.745 ENST00000318833.3
 ZFP3
ZFP3 zinc finger protein
chr19_-_7990991 2.547 ENST00000318978.4
 CTXN1
cortexin 1
chr1_-_46089639 2.453 ENST00000445048.2
 CCDC17
coiled-coil domain containing 17
chr1_-_75139397 2.335 ENST00000326665.5
 C1orf173
chromosome 1 open reading frame 173
chr5_+_156693159 2.260 ENST00000347377.6
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr22_-_50970506 2.251 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chr4_-_177116772 2.225 ENST00000280191.2
 SPATA4
spermatogenesis associated 4
chr16_-_21289627 2.212 ENST00000396023.2
ENST00000415987.2
 CRYM

crystallin, mu

chr2_-_230579185 2.160 ENST00000341772.4
 DNER
delta/notch-like EGF repeat containing
chr14_+_96949319 2.141 ENST00000554706.1
 AK7
adenylate kinase 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 285 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 9.9 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.0 4.9 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.4 4.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 3.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 3.3 GO:0007602 phototransduction(GO:0007602)
0.4 2.9 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 2.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 2.7 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 2.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 2.2 GO:0007220 Notch receptor processing(GO:0007220)
0.2 2.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 2.1 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.6 1.9 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 1.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.8 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.3 1.7 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 1.6 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 1.6 GO:0002209 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.1 1.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 1.5 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 3.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.9 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 3.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.6 2.9 GO:0098536 deuterosome(GO:0098536)
0.1 2.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.2 1.6 GO:0070695 FHF complex(GO:0070695)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 1.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.2 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.3 GO:0042805 actinin binding(GO:0042805)
1.0 4.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 3.5 GO:0019003 GDP binding(GO:0019003)
0.1 2.9 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.6 2.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 2.1 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 2.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 2.0 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.9 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 1.8 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 1.7 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.7 GO:0005112 Notch binding(GO:0005112)
0.0 1.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 1.6 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.3 1.5 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity(GO:0004306)
0.1 1.5 GO:0036374 glutathione hydrolase activity(GO:0036374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.0 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 0.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.7 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 0.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 0.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 1.9 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 1.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis