Motif ID: MIXL1_GSX1_BSX_MEOX2_LHX4

Z-value: 0.668

Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4:

Gene SymbolEntrez IDGene Name
BSX ENSG00000188909.4 BSX
GSX1 ENSG00000169840.4 GSX1
LHX4 ENSG00000121454.4 LHX4
MEOX2 ENSG00000106511.5 MEOX2
MIXL1 ENSG00000185155.7 MIXL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LHX4hg19_v2_chr1_+_180199393_1801994260.511.1e-02Click!
MEOX2hg19_v2_chr7_-_15726296_157264370.272.0e-01Click!
MIXL1hg19_v2_chr1_+_226411319_2264113660.213.2e-01Click!
GSX1hg19_v2_chr13_+_28366780_28366780-0.048.6e-01Click!


Activity profile for motif MIXL1_GSX1_BSX_MEOX2_LHX4.

activity profile for motif MIXL1_GSX1_BSX_MEOX2_LHX4


Sorted Z-values histogram for motif MIXL1_GSX1_BSX_MEOX2_LHX4

Sorted Z-values for motif MIXL1_GSX1_BSX_MEOX2_LHX4



Network of associatons between targets according to the STRING database.



First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_152386732 4.792 ENST00000271835.3
 CRNN
cornulin
chr4_+_69313145 3.402 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr17_-_38859996 1.820 ENST00000264651.2
 KRT24
keratin 24
chr4_-_69111401 1.755 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr10_+_17270214 1.570 ENST00000544301.1
 VIM
vimentin
chr12_+_107712173 1.449 ENST00000280758.5
ENST00000420571.2
 BTBD11

BTB (POZ) domain containing 11

chr16_-_30122717 1.335 ENST00000566613.1
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr2_+_158114051 1.210 ENST00000259056.4
 GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr11_+_33061543 1.196 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1


t-complex 11, testis-specific-like 1


chr1_+_62439037 1.154 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr18_+_29027696 1.114 ENST00000257189.4
 DSG3
desmoglein 3
chr3_-_108248169 1.100 ENST00000273353.3
 MYH15
myosin, heavy chain 15
chr12_-_30887948 1.070 ENST00000433722.2
 CAPRIN2
caprin family member 2
chr2_-_208031943 1.039 ENST00000421199.1
ENST00000457962.1
 KLF7

Kruppel-like factor 7 (ubiquitous)

chr7_-_28220354 1.016 ENST00000283928.5
 JAZF1
JAZF zinc finger 1
chr6_-_66417107 0.967 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
 EYS



eyes shut homolog (Drosophila)



chr12_-_10978957 0.960 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr2_-_216003127 0.948 ENST00000412081.1
ENST00000272895.7
 ABCA12

ATP-binding cassette, sub-family A (ABC1), member 12

chr9_+_12693336 0.902 ENST00000381137.2
ENST00000388918.5
 TYRP1

tyrosinase-related protein 1

chr6_-_32157947 0.859 ENST00000375050.4
 PBX2
pre-B-cell leukemia homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 297 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0031424 keratinization(GO:0031424)
0.0 4.5 GO:0009408 response to heat(GO:0009408)
0.0 3.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.6 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 1.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 1.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.2 1.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 1.2 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.2 1.1 GO:0097338 response to clozapine(GO:0097338)
0.0 1.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.1 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 1.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 1.1 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 1.1 GO:0006023 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.1 1.0 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 1.0 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.3 0.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.4 GO:0005882 intermediate filament(GO:0005882)
0.1 2.9 GO:0001533 cornified envelope(GO:0001533)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.3 GO:0001772 immunological synapse(GO:0001772)
0.1 1.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.9 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.8 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.0 GO:0005549 odorant binding(GO:0005549)
0.0 2.0 GO:0035064 methylated histone binding(GO:0035064)
0.3 1.9 GO:1990254 keratin filament binding(GO:1990254)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.4 GO:0003823 antigen binding(GO:0003823)
0.0 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.0 GO:0015026 coreceptor activity(GO:0015026)
0.2 0.9 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.1 0.9 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.9 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.8 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.1 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 1.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.0 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.0 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.9 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism