Motif ID: MLXIPL

Z-value: 1.317


Transcription factors associated with MLXIPL:

Gene SymbolEntrez IDGene Name
MLXIPL ENSG00000009950.11 MLXIPL

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MLXIPLhg19_v2_chr7_-_73038867_73038878,
hg19_v2_chr7_-_73038822_73038862		0.341.1e-01Click!


Activity profile for motif MLXIPL.

activity profile for motif MLXIPL


Sorted Z-values histogram for motif MLXIPL

Sorted Z-values for motif MLXIPL



Network of associatons between targets according to the STRING database.



First level regulatory network of MLXIPL

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_2249308 1.806 ENST00000592877.1
ENST00000221496.4
 AMH

anti-Mullerian hormone

chr7_-_142247606 1.767 ENST00000390361.3
 TRBV7-3
T cell receptor beta variable 7-3
chr19_-_51472222 1.670 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr19_-_51017881 1.658 ENST00000601207.1
ENST00000598657.1
ENST00000376916.3
 ASPDH


aspartate dehydrogenase domain containing


chr1_-_47407097 1.609 ENST00000457840.2
 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr2_-_89545079 1.561 ENST00000468494.1
 IGKV2-30
immunoglobulin kappa variable 2-30
chr19_-_51472823 1.553 ENST00000310157.2
 KLK6
kallikrein-related peptidase 6
chr19_-_51472031 1.381 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chrX_-_153881842 1.334 ENST00000369585.3
ENST00000247306.4
 CTAG2

cancer/testis antigen 2

chr15_+_45406519 1.222 ENST00000323030.5
 DUOXA2
dual oxidase maturation factor 2
chr17_+_7942335 1.218 ENST00000380183.4
ENST00000572022.1
ENST00000380173.2
 ALOX15B


arachidonate 15-lipoxygenase, type B


chr1_+_150522222 1.215 ENST00000369039.5
 ADAMTSL4
ADAMTS-like 4
chr8_-_23261589 1.203 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2



lysyl oxidase-like 2



chr2_+_233925064 1.198 ENST00000359570.5
ENST00000538935.1
 INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr22_+_31477296 1.191 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
 SMTN




smoothelin




chr19_-_46526304 1.179 ENST00000008938.4
 PGLYRP1
peptidoglycan recognition protein 1
chr10_+_118187379 1.158 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr10_-_118928543 1.139 ENST00000419373.2
 RP11-501J20.2
RP11-501J20.2
chr2_-_113594279 1.138 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr17_+_74381343 1.134 ENST00000392496.3
 SPHK1
sphingosine kinase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 667 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 GO:0016540 protein autoprocessing(GO:0016540)
0.0 4.3 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.1 4.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 3.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 3.2 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 2.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 2.6 GO:0006939 smooth muscle contraction(GO:0006939)
0.6 2.3 GO:0003095 pressure natriuresis(GO:0003095)
0.4 2.3 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.7 2.0 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.7 2.0 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 2.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 1.9 GO:0015803 branched-chain amino acid transport(GO:0015803)
0.2 1.9 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.4 1.8 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.3 1.8 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1 1.7 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.0 1.7 GO:1901998 toxin transport(GO:1901998)
0.2 1.6 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 1.6 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.7 GO:0005610 laminin-5 complex(GO:0005610)
0.1 3.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 2.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.9 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 2.5 GO:0033391 chromatoid body(GO:0033391)
0.0 2.5 GO:0043197 dendritic spine(GO:0043197)
0.0 2.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.2 GO:0005604 basement membrane(GO:0005604)
0.2 1.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.8 GO:0030016 myofibril(GO:0030016)
0.0 1.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 1.6 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.1 1.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.6 GO:0042627 chylomicron(GO:0042627)
0.0 1.5 GO:0001533 cornified envelope(GO:0001533)
0.0 1.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.4 GO:0005861 troponin complex(GO:0005861)
0.0 1.3 GO:0031904 endosome lumen(GO:0031904)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 416 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.5 GO:0003924 GTPase activity(GO:0003924)
0.1 3.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 3.2 GO:0005179 hormone activity(GO:0005179)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.9 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 2.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.6 2.3 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 2.3 GO:0050699 WW domain binding(GO:0050699)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.1 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 2.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 2.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 1.9 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.1 1.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.8 GO:0019843 rRNA binding(GO:0019843)
0.1 1.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.7 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 6.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 3.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 2.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 2.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.1 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.0 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.9 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 1.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.8 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 1.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.6 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 4.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 3.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 3.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 2.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.9 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 1.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.7 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 1.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.6 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling