Motif ID: MLX_USF2_USF1_PAX2

Z-value: 0.797

Transcription factors associated with MLX_USF2_USF1_PAX2:

Gene SymbolEntrez IDGene Name
MLX ENSG00000108788.7 MLX
PAX2 ENSG00000075891.17 PAX2
USF1 ENSG00000158773.10 USF1
USF2 ENSG00000105698.11 USF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MLXhg19_v2_chr17_+_40719073_40719092-0.452.7e-02Click!
USF1hg19_v2_chr1_-_161014731_1610147880.135.6e-01Click!
PAX2hg19_v2_chr10_+_102505468_102505546-0.106.4e-01Click!
USF2hg19_v2_chr19_+_35759824_35759891-0.077.3e-01Click!


Activity profile for motif MLX_USF2_USF1_PAX2.

activity profile for motif MLX_USF2_USF1_PAX2


Sorted Z-values histogram for motif MLX_USF2_USF1_PAX2

Sorted Z-values for motif MLX_USF2_USF1_PAX2



Network of associatons between targets according to the STRING database.



First level regulatory network of MLX_USF2_USF1_PAX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_19988462 4.121 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr1_-_42921915 4.061 ENST00000372565.3
ENST00000433602.2
 ZMYND12

zinc finger, MYND-type containing 12

chr19_-_10764509 3.912 ENST00000591501.1
 ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr1_-_207119738 3.826 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr12_+_50355647 3.234 ENST00000293599.6
 AQP5
aquaporin 5
chr17_+_72270380 2.661 ENST00000582036.1
ENST00000307504.5
 DNAI2

dynein, axonemal, intermediate chain 2

chr17_+_72270429 2.586 ENST00000311014.6
 DNAI2
dynein, axonemal, intermediate chain 2
chr16_+_84178874 2.252 ENST00000378553.5
 DNAAF1
dynein, axonemal, assembly factor 1
chr12_-_63328817 2.115 ENST00000228705.6
 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr5_+_172483347 2.029 ENST00000522692.1
ENST00000296953.2
ENST00000540014.1
ENST00000520420.1
 CREBRF



CREB3 regulatory factor



chr1_+_183605200 1.896 ENST00000304685.4
 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr8_+_75896731 1.839 ENST00000262207.4
 CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr11_+_65479702 1.823 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
 KAT5





K(lysine) acetyltransferase 5





chr14_-_54420133 1.728 ENST00000559501.1
ENST00000558984.1
 BMP4

bone morphogenetic protein 4

chr17_+_17876127 1.702 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
 LRRC48









leucine rich repeat containing 48









chr19_+_5720666 1.685 ENST00000381624.3
ENST00000381614.2
 CATSPERD

catsper channel auxiliary subunit delta

chrX_+_55744228 1.683 ENST00000262850.7
 RRAGB
Ras-related GTP binding B
chr3_-_122512619 1.681 ENST00000383659.1
ENST00000306103.2
 HSPBAP1

HSPB (heat shock 27kDa) associated protein 1

chr2_-_220108309 1.676 ENST00000409640.1
 GLB1L
galactosidase, beta 1-like
chr7_+_106685079 1.661 ENST00000265717.4
 PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 347 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.6 GO:0036158 outer dynein arm assembly(GO:0036158)
1.2 6.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.6 5.3 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.4 3.9 GO:0015889 cobalamin transport(GO:0015889)
0.1 3.1 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.6 3.0 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 2.7 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.2 2.5 GO:0060155 platelet dense granule organization(GO:0060155)
0.7 2.0 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 2.0 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.6 1.8 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.4 1.8 GO:0006740 NADPH regeneration(GO:0006740)
0.6 1.7 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.2 1.7 GO:0097338 response to clozapine(GO:0097338)
0.1 1.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 1.7 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.7 GO:0016266 O-glycan processing(GO:0016266)
0.4 1.6 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.3 1.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.2 GO:0036157 outer dynein arm(GO:0036157)
0.8 4.8 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 4.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.5 3.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 3.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 3.0 GO:0043202 lysosomal lumen(GO:0043202)
0.1 2.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 2.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 2.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 2.0 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 1.7 GO:0036128 CatSper complex(GO:0036128)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.7 GO:0031514 motile cilium(GO:0031514)
0.2 1.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 1.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 GO:0005507 copper ion binding(GO:0005507)
0.2 5.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 3.9 GO:0031419 cobalamin binding(GO:0031419)
0.5 3.8 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 3.7 GO:0050681 androgen receptor binding(GO:0050681)
1.1 3.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 3.2 GO:0015250 water channel activity(GO:0015250)
0.1 2.5 GO:0070840 dynein complex binding(GO:0070840)
0.0 2.5 GO:0042393 histone binding(GO:0042393)
0.2 2.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.3 1.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.6 1.8 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.6 1.8 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 1.8 GO:0051287 NAD binding(GO:0051287)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 1.7 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.2 1.7 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.7 GO:0070700 co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700)
0.1 1.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 4.3 PID_MYC_PATHWAY C-MYC pathway
0.0 4.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 3.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.3 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.2 PID_ATM_PATHWAY ATM pathway
0.0 1.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 2.5 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ Genes involved in Cyclin E associated events during G1/S transition
0.0 2.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.0 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.9 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.5 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.2 REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 1.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.7 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.7 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases