Motif ID: MNT_HEY1_HEY2

Z-value: 0.596

Transcription factors associated with MNT_HEY1_HEY2:

Gene SymbolEntrez IDGene Name
HEY1 ENSG00000164683.12 HEY1
HEY2 ENSG00000135547.4 HEY2
MNT ENSG00000070444.10 MNT

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MNThg19_v2_chr17_-_2304365_2304412-0.546.8e-03Click!
HEY1hg19_v2_chr8_-_80680078_806801010.331.2e-01Click!
HEY2hg19_v2_chr6_+_126070726_1260707680.262.2e-01Click!


Activity profile for motif MNT_HEY1_HEY2.

activity profile for motif MNT_HEY1_HEY2


Sorted Z-values histogram for motif MNT_HEY1_HEY2

Sorted Z-values for motif MNT_HEY1_HEY2



Network of associatons between targets according to the STRING database.



First level regulatory network of MNT_HEY1_HEY2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_17354617 1.260 ENST00000470360.1
 SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr8_+_17354587 1.112 ENST00000494857.1
ENST00000522656.1
 SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr9_-_124976185 0.948 ENST00000464484.2
 LHX6
LIM homeobox 6
chr9_-_124976154 0.886 ENST00000482062.1
 LHX6
LIM homeobox 6
chr13_+_35516390 0.864 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr6_+_73331918 0.837 ENST00000402622.2
ENST00000355635.3
ENST00000403813.2
ENST00000414165.2
 KCNQ5



potassium voltage-gated channel, KQT-like subfamily, member 5



chr1_-_109656439 0.801 ENST00000369949.4
 C1orf194
chromosome 1 open reading frame 194
chr17_-_17109579 0.781 ENST00000321560.3
 PLD6
phospholipase D family, member 6
chr3_-_19988462 0.750 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr12_-_58146128 0.724 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
 CDK4


cyclin-dependent kinase 4


chr8_-_110656995 0.704 ENST00000276646.9
ENST00000533065.1
 SYBU

syntabulin (syntaxin-interacting)

chr6_-_39197226 0.677 ENST00000359534.3
 KCNK5
potassium channel, subfamily K, member 5
chr1_-_42921915 0.636 ENST00000372565.3
ENST00000433602.2
 ZMYND12

zinc finger, MYND-type containing 12

chr12_-_58146048 0.636 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
 CDK4




cyclin-dependent kinase 4




chr3_-_71834318 0.612 ENST00000353065.3
 PROK2
prokineticin 2
chr1_+_150254936 0.607 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
 C1orf51


chromosome 1 open reading frame 51


chr11_+_65479702 0.595 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
 KAT5





K(lysine) acetyltransferase 5





chr15_+_45315302 0.594 ENST00000267814.9
 SORD
sorbitol dehydrogenase
chr8_+_75896731 0.589 ENST00000262207.4
 CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr3_+_113666748 0.587 ENST00000330212.3
ENST00000498275.1
 ZDHHC23

zinc finger, DHHC-type containing 23


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 291 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.4 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.2 2.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 1.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 1.4 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1 1.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 1.3 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.1 GO:0000732 strand displacement(GO:0000732)
0.2 0.8 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021)
0.1 0.8 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.8 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 0.7 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.1 0.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.7 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.6 GO:0006059 hexitol metabolic process(GO:0006059)
0.2 0.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.6 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.1 0.6 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.6 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0031519 PcG protein complex(GO:0031519)
0.2 1.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 1.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.3 GO:0097433 dense body(GO:0097433)
0.0 1.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.0 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.0 GO:0033391 chromatoid body(GO:0033391)
0.1 0.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.8 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.1 0.6 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 0.5 GO:0036128 CatSper complex(GO:0036128)
0.1 0.5 GO:0005827 polar microtubule(GO:0005827)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.4 GO:1902937 inward rectifier potassium channel complex(GO:1902937)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.4 GO:0005289 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.0 2.2 GO:0030332 cyclin binding(GO:0030332)
0.0 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.2 0.8 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.1 0.8 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 0.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.8 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 0.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.2 PID_MYC_PATHWAY C-MYC pathway
0.0 1.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.2 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.8 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.4 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation