Motif ID: MSX1

Z-value: 0.412


Transcription factors associated with MSX1:

Gene SymbolEntrez IDGene Name
MSX1 ENSG00000163132.6 MSX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MSX1hg19_v2_chr4_+_4861385_4861398-0.164.5e-01Click!


Activity profile for motif MSX1.

activity profile for motif MSX1


Sorted Z-values histogram for motif MSX1

Sorted Z-values for motif MSX1



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_26240561 0.955 ENST00000377745.2
 HIST1H4F
histone cluster 1, H4f
chr2_-_158345462 0.766 ENST00000439355.1
ENST00000540637.1
 CYTIP

cytohesin 1 interacting protein

chr3_-_123339418 0.663 ENST00000583087.1
 MYLK
myosin light chain kinase
chr3_-_123339343 0.650 ENST00000578202.1
 MYLK
myosin light chain kinase
chr3_-_123512688 0.620 ENST00000475616.1
 MYLK
myosin light chain kinase
chr2_-_209028300 0.614 ENST00000304502.4
 CRYGA
crystallin, gamma A
chr11_-_102496063 0.431 ENST00000260228.2
 MMP20
matrix metallopeptidase 20
chr2_-_145278475 0.408 ENST00000558170.2
 ZEB2
zinc finger E-box binding homeobox 2
chr1_-_160492994 0.390 ENST00000368055.1
ENST00000368057.3
ENST00000368059.3
 SLAMF6


SLAM family member 6


chr7_-_56101826 0.342 ENST00000421626.1
 PSPH
phosphoserine phosphatase
chr2_-_169746878 0.307 ENST00000282074.2
 SPC25
SPC25, NDC80 kinetochore complex component
chrY_-_2655644 0.307 ENST00000525526.2
ENST00000534739.2
ENST00000383070.1
 SRY


sex determining region Y


chr13_-_88323218 0.304 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
 MIR4500HG


MIR4500 host gene (non-protein coding)


chr1_+_158985457 0.302 ENST00000567661.1
ENST00000474473.1
 IFI16

interferon, gamma-inducible protein 16

chr6_-_76072719 0.297 ENST00000370020.1
 FILIP1
filamin A interacting protein 1
chr17_-_8113542 0.279 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
 AURKB


aurora kinase B


chr10_-_29923893 0.268 ENST00000355867.4
 SVIL
supervillin
chr21_+_33671264 0.259 ENST00000339944.4
 MRAP
melanocortin 2 receptor accessory protein
chr10_+_17270214 0.253 ENST00000544301.1
 VIM
vimentin
chr4_+_169013666 0.252 ENST00000359299.3
 ANXA10
annexin A10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.4 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.4 GO:0001787 natural killer cell proliferation(GO:0001787)
0.1 0.3 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.3 GO:2000020 positive regulation of male gonad development(GO:2000020)
0.0 0.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 0.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.2 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.0 0.1 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.1 GO:1904760 peptidyl-serine ADP-ribosylation(GO:0018312) myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.0 0.1 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.1 GO:0071284 cellular response to lead ion(GO:0071284) positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:1990523 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0042611 MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection