Motif ID: MSX2

Z-value: 0.335


Transcription factors associated with MSX2:

Gene SymbolEntrez IDGene Name
MSX2 ENSG00000120149.7 MSX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MSX2hg19_v2_chr5_+_174151536_1741516100.125.9e-01Click!


Activity profile for motif MSX2.

activity profile for motif MSX2


Sorted Z-values histogram for motif MSX2

Sorted Z-values for motif MSX2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_54967187 0.519 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA













aurora kinase A













chr12_-_120315074 0.502 ENST00000261833.7
ENST00000392521.2
CIT

citron (rho-interacting, serine/threonine kinase 21)

chr12_+_53662073 0.386 ENST00000553219.1
ENST00000257934.4
ESPL1

extra spindle pole bodies homolog 1 (S. cerevisiae)

chr8_+_1993173 0.378 ENST00000523438.1
MYOM2
myomesin 2
chr8_+_1993152 0.376 ENST00000262113.4
MYOM2
myomesin 2
chr12_+_53662110 0.309 ENST00000552462.1
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr17_-_38574169 0.258 ENST00000423485.1
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr10_-_99447024 0.220 ENST00000370626.3
AVPI1
arginine vasopressin-induced 1
chr6_+_130339710 0.205 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr11_+_33061543 0.185 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1


t-complex 11, testis-specific-like 1


chr1_-_197115818 0.181 ENST00000367409.4
ENST00000294732.7
ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr6_+_53948328 0.176 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr1_-_232651312 0.176 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr6_-_111927062 0.168 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr2_-_55646957 0.167 ENST00000263630.8
CCDC88A
coiled-coil domain containing 88A
chr2_-_55647057 0.161 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr12_+_9102632 0.158 ENST00000539240.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr10_-_105110831 0.155 ENST00000337211.4
PCGF6
polycomb group ring finger 6
chr19_+_42817450 0.147 ENST00000301204.3
TMEM145
transmembrane protein 145
chr10_-_105110890 0.145 ENST00000369847.3
PCGF6
polycomb group ring finger 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 0.7 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.2 0.5 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.1 0.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.2 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.1 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.1 GO:0033504 floor plate development(GO:0033504)
0.0 0.1 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.1 0.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.3 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)

Gene overrepresentation in molecular_function category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.3 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.0 GO:0033149 FFAT motif binding(GO:0033149)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection