Motif ID: MYBL1

Z-value: 0.866


Transcription factors associated with MYBL1:

Gene SymbolEntrez IDGene Name
MYBL1 ENSG00000185697.12 MYBL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MYBL1hg19_v2_chr8_-_67525524_67525543-0.424.2e-02Click!


Activity profile for motif MYBL1.

activity profile for motif MYBL1


Sorted Z-values histogram for motif MYBL1

Sorted Z-values for motif MYBL1



Network of associatons between targets according to the STRING database.



First level regulatory network of MYBL1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_55672037 2.661 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr6_+_28109703 2.270 ENST00000457389.2
ENST00000330236.6
 ZKSCAN8

zinc finger with KRAB and SCAN domains 8

chr16_-_21289627 2.015 ENST00000396023.2
ENST00000415987.2
 CRYM

crystallin, mu

chr2_-_73460334 1.845 ENST00000258083.2
 PRADC1
protease-associated domain containing 1
chr17_-_6735012 1.695 ENST00000535086.1
 TEKT1
tektin 1
chr6_+_26240561 1.584 ENST00000377745.2
 HIST1H4F
histone cluster 1, H4f
chr6_-_32557610 1.475 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr3_+_58223228 1.213 ENST00000478253.1
ENST00000295962.4
 ABHD6

abhydrolase domain containing 6

chr1_+_85527987 1.185 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
 WDR63


WD repeat domain 63


chr3_-_51975942 1.100 ENST00000232888.6
 RRP9
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
chr4_+_15471489 1.083 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
 CC2D2A








coiled-coil and C2 domain containing 2A








chr18_-_71814999 1.044 ENST00000269500.5
 FBXO15
F-box protein 15
chr18_-_71815051 1.038 ENST00000582526.1
ENST00000419743.2
 FBXO15

F-box protein 15

chr5_+_140186647 0.924 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4


protocadherin alpha 4


chr4_-_177116772 0.877 ENST00000280191.2
 SPATA4
spermatogenesis associated 4
chr3_-_49314640 0.868 ENST00000436325.1
 C3orf62
chromosome 3 open reading frame 62
chr6_-_133119668 0.853 ENST00000275227.4
ENST00000538764.1
 SLC18B1

solute carrier family 18, subfamily B, member 1

chr1_-_227505289 0.836 ENST00000366765.3
 CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr1_+_171217622 0.826 ENST00000433267.1
ENST00000367750.3
 FMO1

flavin containing monooxygenase 1

chr15_+_66797627 0.825 ENST00000565627.1
ENST00000564179.1
 ZWILCH

zwilch kinetochore protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0044458 motile cilium assembly(GO:0044458)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 1.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 1.7 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.3 1.5 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 1.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.3 1.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 1.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 1.2 GO:0034969 histone arginine methylation(GO:0034969)
0.2 1.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.3 1.0 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 1.0 GO:2000111 positive regulation of macrophage apoptotic process(GO:2000111)
0.0 0.9 GO:0042073 intraciliary transport(GO:0042073)
0.1 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.8 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.8 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 0.7 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.2 0.7 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.7 GO:0036126 sperm flagellum(GO:0036126)
0.4 1.5 GO:1990423 RZZ complex(GO:1990423)
0.0 1.3 GO:0030286 dynein complex(GO:0030286)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 1.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.1 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.0 1.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.0 GO:0005879 axonemal microtubule(GO:0005879)
0.1 1.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 0.6 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0042605 peptide antigen binding(GO:0042605)
0.5 2.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 1.6 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 1.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.0 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 0.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.7 GO:0010181 FMN binding(GO:0010181)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.6 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.6 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.5 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 0.2 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.1 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.1 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL