Motif ID: MYBL2

Z-value: 1.912


Transcription factors associated with MYBL2:

Gene SymbolEntrez IDGene Name
MYBL2 ENSG00000101057.11 MYBL2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MYBL2hg19_v2_chr20_+_42295745_422957970.281.9e-01Click!


Activity profile for motif MYBL2.

activity profile for motif MYBL2


Sorted Z-values histogram for motif MYBL2

Sorted Z-values for motif MYBL2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYBL2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_50383096 6.162 ENST00000442887.1
ENST00000360165.3
 ZMYND10

zinc finger, MYND-type containing 10

chr9_+_72435709 3.994 ENST00000377197.3
ENST00000527647.1
 C9orf135

chromosome 9 open reading frame 135

chr1_+_91966384 3.585 ENST00000430031.2
ENST00000234626.6
 CDC7

cell division cycle 7

chr2_-_27712583 3.504 ENST00000260570.3
ENST00000359466.6
ENST00000416524.2
 IFT172


intraflagellar transport 172 homolog (Chlamydomonas)


chr2_+_201390843 3.499 ENST00000357799.4
ENST00000409203.3
 SGOL2

shugoshin-like 2 (S. pombe)

chr12_+_110906169 3.337 ENST00000377673.5
 FAM216A
family with sequence similarity 216, member A
chr1_+_85527987 3.230 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
 WDR63


WD repeat domain 63


chr1_+_171060018 3.173 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
 FMO3




flavin containing monooxygenase 3




chr12_-_58329819 3.156 ENST00000551421.1
 RP11-620J15.3
RP11-620J15.3
chr19_+_5914213 2.982 ENST00000222125.5
ENST00000452990.2
ENST00000588865.1
 CAPS


calcyphosine


chr11_+_101918153 2.920 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr1_+_91966656 2.840 ENST00000428239.1
ENST00000426137.1
 CDC7

cell division cycle 7

chr14_-_75536182 2.802 ENST00000555463.1
 ACYP1
acylphosphatase 1, erythrocyte (common) type
chr13_+_50589390 2.685 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr14_-_75530693 2.574 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
 ACYP1




acylphosphatase 1, erythrocyte (common) type




chr3_-_45957088 2.562 ENST00000539217.1
 LZTFL1
leucine zipper transcription factor-like 1
chr7_-_123174610 2.554 ENST00000324698.6
ENST00000434450.1
 IQUB

IQ motif and ubiquitin domain containing

chr6_+_163148161 2.526 ENST00000337019.3
ENST00000366889.2
 PACRG

PARK2 co-regulated

chr4_+_128802016 2.519 ENST00000270861.5
ENST00000515069.1
ENST00000513090.1
ENST00000507249.1
 PLK4



polo-like kinase 4



chr22_-_42342692 2.484 ENST00000404067.1
ENST00000402338.1
 CENPM

centromere protein M


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 6.9 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 6.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.8 6.4 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 5.6 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 5.3 GO:0003351 epithelial cilium movement(GO:0003351)
1.6 4.8 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.3 3.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 3.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.9 3.6 GO:0032053 ciliary basal body organization(GO:0032053)
0.3 3.5 GO:0061525 hindgut development(GO:0061525)
0.0 3.3 GO:0007224 smoothened signaling pathway(GO:0007224)
0.7 2.9 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 2.9 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 2.9 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 2.6 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.5 2.5 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.5 2.4 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.2 2.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 2.4 GO:0007099 centriole replication(GO:0007099)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0005814 centriole(GO:0005814)
0.1 7.4 GO:0005801 cis-Golgi network(GO:0005801)
0.2 6.9 GO:0034451 centriolar satellite(GO:0034451)
0.1 6.5 GO:0045171 intercellular bridge(GO:0045171)
0.2 6.2 GO:0035371 microtubule plus-end(GO:0035371)
0.1 5.3 GO:0030286 dynein complex(GO:0030286)
0.0 5.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.6 4.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 4.4 GO:0005874 microtubule(GO:0005874)
0.1 3.8 GO:0005876 spindle microtubule(GO:0005876)
0.7 3.6 GO:0098536 deuterosome(GO:0098536)
1.2 3.5 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 3.5 GO:0031514 motile cilium(GO:0031514)
0.0 3.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 3.2 GO:0036038 MKS complex(GO:0036038)
0.3 3.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 3.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.6 2.9 GO:0005879 axonemal microtubule(GO:0005879)
0.0 2.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 2.5 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 GO:0045503 dynein light chain binding(GO:0045503)
0.1 5.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.9 5.4 GO:0003998 acylphosphatase activity(GO:0003998)
0.5 4.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 3.7 GO:0008017 microtubule binding(GO:0008017)
0.1 3.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 2.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.3 2.4 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.3 2.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 2.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 2.3 GO:0050699 WW domain binding(GO:0050699)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 2.1 GO:0032143 single thymine insertion binding(GO:0032143)
0.2 2.1 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.4 2.0 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity(GO:0004306)
0.0 2.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 1.9 GO:0035174 histone serine kinase activity(GO:0035174)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 7.1 PID_PLK1_PATHWAY PLK1 signaling events
0.0 3.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 2.0 PID_MYC_PATHWAY C-MYC pathway
0.0 1.3 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.1 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 9.1 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 4.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 2.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.4 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.7 2.2 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.8 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.7 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.2 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 1.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 1.0 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.7 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors