Motif ID: MZF1

Z-value: 0.620


Transcription factors associated with MZF1:

Gene SymbolEntrez IDGene Name
MZF1 ENSG00000099326.4 MZF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MZF1hg19_v2_chr19_-_59084922_59084947-0.009.9e-01Click!


Activity profile for motif MZF1.

activity profile for motif MZF1


Sorted Z-values histogram for motif MZF1

Sorted Z-values for motif MZF1



Network of associatons between targets according to the STRING database.



First level regulatory network of MZF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_150208320 1.111 ENST00000534220.1
 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr19_-_51472823 1.093 ENST00000310157.2
 KLK6
kallikrein-related peptidase 6
chr6_-_32157947 0.815 ENST00000375050.4
 PBX2
pre-B-cell leukemia homeobox 2
chr5_-_127873659 0.579 ENST00000262464.4
 FBN2
fibrillin 2
chr1_-_205419053 0.564 ENST00000367154.1
 LEMD1
LEM domain containing 1
chr11_-_2160180 0.525 ENST00000381406.4
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_-_114664180 0.512 ENST00000312719.5
 HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr17_+_39969183 0.510 ENST00000321562.4
 FKBP10
FK506 binding protein 10, 65 kDa
chr17_+_42634844 0.499 ENST00000315323.3
 FZD2
frizzled family receptor 2
chr17_+_76210267 0.493 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
 BIRC5



baculoviral IAP repeat containing 5



chr19_+_35645817 0.492 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr19_+_35645618 0.475 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr10_+_31608054 0.448 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
 ZEB1





zinc finger E-box binding homeobox 1





chr14_+_24867992 0.437 ENST00000382554.3
 NYNRIN
NYN domain and retroviral integrase containing
chr19_-_49015050 0.431 ENST00000600059.1
 LMTK3
lemur tyrosine kinase 3
chr2_-_72375167 0.409 ENST00000001146.2
 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr15_-_74501360 0.388 ENST00000323940.5
 STRA6
stimulated by retinoic acid 6
chr17_+_76210367 0.386 ENST00000592734.1
ENST00000587746.1
 BIRC5

baculoviral IAP repeat containing 5

chr2_-_216300784 0.384 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr1_+_66999268 0.382 ENST00000371039.1
ENST00000424320.1
 SGIP1

SH3-domain GRB2-like (endophilin) interacting protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0043486 histone exchange(GO:0043486)
0.1 1.2 GO:0016540 protein autoprocessing(GO:0016540)
0.3 1.0 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0 0.9 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 0.8 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.8 GO:0060346 bone trabecula formation(GO:0060346)
0.1 0.7 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.7 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.2 0.6 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 0.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.6 GO:1902617 response to fluoride(GO:1902617)
0.1 0.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.6 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.2 0.5 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 0.5 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.1 0.5 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 0.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.9 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.6 GO:0005916 fascia adherens(GO:0005916)
0.1 0.5 GO:0035976 AP1 complex(GO:0035976)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.4 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0016589 NURF complex(GO:0016589)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 1.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.8 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.6 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.5 GO:0016499 orexin receptor activity(GO:0016499)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 0.4 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.1 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.4 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.4 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.3 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants