Motif ID: NANOG

Z-value: 0.436


Transcription factors associated with NANOG:

Gene SymbolEntrez IDGene Name
NANOG ENSG00000111704.6 NANOG

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NANOGhg19_v2_chr12_+_7941989_7942014-0.193.7e-01Click!


Activity profile for motif NANOG.

activity profile for motif NANOG


Sorted Z-values histogram for motif NANOG

Sorted Z-values for motif NANOG



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG

PNG image of the network

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Top targets:


Showing 1 to 20 of 185 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_47655686 0.565 ENST00000294338.2
 PDZK1IP1
PDZK1 interacting protein 1
chr8_+_22022800 0.544 ENST00000397814.3
 BMP1
bone morphogenetic protein 1
chr12_-_123187890 0.495 ENST00000328880.5
 HCAR2
hydroxycarboxylic acid receptor 2
chr12_-_123201337 0.487 ENST00000528880.2
 HCAR3
hydroxycarboxylic acid receptor 3
chr10_+_102891048 0.443 ENST00000467928.2
 TLX1
T-cell leukemia homeobox 1
chr16_+_640201 0.442 ENST00000563109.1
 RAB40C
RAB40C, member RAS oncogene family
chr22_+_42095497 0.311 ENST00000401548.3
ENST00000540833.1
ENST00000400107.1
ENST00000300398.4
 MEI1



meiosis inhibitor 1



chr6_-_33714752 0.304 ENST00000451316.1
 IP6K3
inositol hexakisphosphate kinase 3
chr6_-_33714667 0.297 ENST00000293756.4
 IP6K3
inositol hexakisphosphate kinase 3
chr6_-_30524951 0.251 ENST00000376621.3
 GNL1
guanine nucleotide binding protein-like 1
chr8_-_91095099 0.249 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr10_+_123923105 0.247 ENST00000368999.1
 TACC2
transforming, acidic coiled-coil containing protein 2
chr10_-_48390973 0.244 ENST00000224600.4
 RBP3
retinol binding protein 3, interstitial
chr10_+_123922941 0.240 ENST00000360561.3
 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_28520384 0.239 ENST00000305392.3
 PTAFR
platelet-activating factor receptor
chr15_+_41549105 0.238 ENST00000560965.1
 CHP1
calcineurin-like EF-hand protein 1
chrX_-_107019181 0.237 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
 TSC22D3



TSC22 domain family, member 3



chr4_+_166248775 0.237 ENST00000261507.6
ENST00000507013.1
ENST00000393766.2
ENST00000504317.1
 MSMO1



methylsterol monooxygenase 1



chr2_-_214016314 0.227 ENST00000434687.1
ENST00000374319.4
 IKZF2

IKAROS family zinc finger 2 (Helios)

chr8_+_22022653 0.224 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
 BMP1


bone morphogenetic protein 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0034380 cartilage condensation(GO:0001502) high-density lipoprotein particle assembly(GO:0034380)
0.0 0.6 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.5 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.3 GO:0045141 meiotic telomere clustering(GO:0045141)
0.1 0.2 GO:1904298 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
0.1 0.2 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0 0.2 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0 0.2 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.2 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0032242 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.1 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.1 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.1 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.0 0.1 GO:0001172 transcription, RNA-templated(GO:0001172)
0.0 0.1 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.2 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.6 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.1 0.2 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.2 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.0 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones