Motif ID: NFAT5

Z-value: 0.753


Transcription factors associated with NFAT5:

Gene SymbolEntrez IDGene Name
NFAT5 ENSG00000102908.16 NFAT5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFAT5hg19_v2_chr16_+_69600058_69600111,
hg19_v2_chr16_+_69599861_69599887		0.538.2e-03Click!


Activity profile for motif NFAT5.

activity profile for motif NFAT5


Sorted Z-values histogram for motif NFAT5

Sorted Z-values for motif NFAT5



Network of associatons between targets according to the STRING database.



First level regulatory network of NFAT5

PNG image of the network

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Top targets:


Showing 1 to 20 of 170 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_24765248 2.874 ENST00000580774.1
ENST00000284224.8
 CHST9

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9

chr1_+_111888890 2.771 ENST00000369738.4
 PIFO
primary cilia formation
chr1_+_111889212 2.693 ENST00000369737.4
 PIFO
primary cilia formation
chr9_-_80263220 2.493 ENST00000341700.6
 GNA14
guanine nucleotide binding protein (G protein), alpha 14
chr20_-_44176060 2.342 ENST00000354280.4
ENST00000504988.1
 EPPIN
EPPIN-WFDC6
epididymal peptidase inhibitor
EPPIN-WFDC6 readthrough
chr20_-_44176391 2.119 ENST00000409554.1
 EPPIN
epididymal peptidase inhibitor
chr17_+_68071458 1.931 ENST00000589377.1
 KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 1.916 ENST00000283936.1
ENST00000392671.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr17_+_45908974 1.860 ENST00000269025.4
 LRRC46
leucine rich repeat containing 46
chr1_-_60539405 1.643 ENST00000450089.2
 C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 1.617 ENST00000371201.3
 C1orf87
chromosome 1 open reading frame 87
chr5_+_156712372 1.530 ENST00000541131.1
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr8_-_133772794 1.410 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
 TMEM71




transmembrane protein 71




chr1_+_54359854 1.344 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
 DIO1





deiodinase, iodothyronine, type I





chr16_+_2079637 1.262 ENST00000561844.1
 SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr20_-_44176013 1.232 ENST00000555685.1
 EPPIN
epididymal peptidase inhibitor
chr12_+_69742121 1.232 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
 LYZ


lysozyme


chr12_+_119772502 1.196 ENST00000536742.1
ENST00000327554.2
 CCDC60

coiled-coil domain containing 60

chr5_+_140186647 1.191 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4


protocadherin alpha 4


chr3_+_49027308 1.006 ENST00000383729.4
ENST00000343546.4
 P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.7 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.1 3.9 GO:0006536 glutamate metabolic process(GO:0006536)
0.1 3.8 GO:0010107 potassium ion import(GO:0010107)
0.1 2.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 2.5 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.2 1.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 1.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 1.3 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 1.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 1.0 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 1.0 GO:0002829 negative regulation of type 2 immune response(GO:0002829)
0.0 1.0 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.1 0.9 GO:0051601 exocyst localization(GO:0051601)
0.2 0.8 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.1 0.8 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.8 GO:0048286 lung alveolus development(GO:0048286)
0.1 0.7 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 0.7 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 5.5 GO:0036064 ciliary basal body(GO:0036064)
0.1 4.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.1 0.8 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.7 GO:0097418 neurofibrillary tangle(GO:0097418)
0.1 0.5 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 5.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 3.9 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.2 3.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 2.9 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 2.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 2.2 GO:0032947 protein complex scaffold(GO:0032947)
0.5 1.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 1.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 1.3 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 1.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.0 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.8 GO:0003796 lysozyme activity(GO:0003796)
0.2 0.7 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.5 GO:0000150 recombinase activity(GO:0000150)
0.0 0.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 2.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.9 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 2.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.5 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.5 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis