Motif ID: NFATC1

Z-value: 1.112


Transcription factors associated with NFATC1:

Gene SymbolEntrez IDGene Name
NFATC1 ENSG00000131196.13 NFATC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC1hg19_v2_chr18_+_77155856_771559390.592.2e-03Click!


Activity profile for motif NFATC1.

activity profile for motif NFATC1


Sorted Z-values histogram for motif NFATC1

Sorted Z-values for motif NFATC1



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_16085340 8.239 ENST00000508167.1
PROM1
prominin 1
chr4_-_16085314 8.219 ENST00000510224.1
PROM1
prominin 1
chr6_+_32407619 7.444 ENST00000395388.2
ENST00000374982.5
HLA-DRA

major histocompatibility complex, class II, DR alpha

chr4_-_100356291 5.970 ENST00000476959.1
ENST00000482593.1
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr14_-_92413727 4.783 ENST00000267620.10
FBLN5
fibulin 5
chr1_-_161337662 4.419 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr6_-_32920794 4.121 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA


XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha


Uncharacterized protein
chr5_-_54468974 3.882 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
CDC20B




cell division cycle 20B




chr1_-_36906474 3.473 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr14_-_92413353 3.435 ENST00000556154.1
FBLN5
fibulin 5
chr4_-_38806404 3.398 ENST00000308979.2
ENST00000505940.1
ENST00000515861.1
TLR1


toll-like receptor 1


chr9_+_124922171 3.162 ENST00000373764.3
ENST00000536616.1
MORN5

MORN repeat containing 5

chr1_+_151682909 3.004 ENST00000326413.3
ENST00000442233.2
RIIAD1
AL589765.1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr1_+_36549676 2.969 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr5_+_140261703 2.921 ENST00000409494.1
ENST00000289272.2
PCDHA13

protocadherin alpha 13

chr10_+_94590910 2.864 ENST00000371547.4
EXOC6
exocyst complex component 6
chrX_-_99665262 2.851 ENST00000373034.4
ENST00000255531.7
PCDH19

protocadherin 19

chr10_+_115511213 2.817 ENST00000361048.1
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr7_+_6793740 2.782 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
RSPH10B2



radial spoke head 10 homolog B2 (Chlamydomonas)



chr7_-_6010263 2.746 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 16.5 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
2.9 11.6 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 8.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 8.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 7.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
2.0 6.0 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 4.8 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.2 3.9 GO:0072189 ureter development(GO:0072189)
1.1 3.4 GO:0042495 detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 3.3 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 3.0 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 2.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.4 GO:0007379 segment specification(GO:0007379)
0.1 2.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 2.0 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 1.8 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 1.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 1.6 GO:0016575 histone deacetylation(GO:0016575)
0.1 1.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 1.5 GO:0036315 cellular response to sterol(GO:0036315)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 16.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.6 11.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.8 8.2 GO:0071953 elastic fiber(GO:0071953)
0.0 5.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 4.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.7 GO:0005923 bicellular tight junction(GO:0005923)
1.1 3.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 3.0 GO:0036126 sperm flagellum(GO:0036126)
0.1 2.9 GO:0000145 exocyst(GO:0000145)
0.1 2.0 GO:0031143 pseudopodium(GO:0031143)
0.0 2.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.4 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.3 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.2 1.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.1 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.1 GO:0030286 dynein complex(GO:0030286)
0.2 0.8 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.0 GO:0042805 actinin binding(GO:0042805)
0.4 12.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 11.0 GO:0008022 protein C-terminus binding(GO:0008022)
1.5 6.0 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 5.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 5.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 3.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.8 3.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 2.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.1 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.7 2.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.9 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 1.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 1.5 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.4 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.2 1.4 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 1.4 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 1.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 7.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 6.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 5.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 3.7 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.0 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.8 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.1 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_ATM_PATHWAY ATM pathway
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 5.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 4.2 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.1 3.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.9 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.3 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 1.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.9 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.9 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.7 REACTOME_XENOBIOTICS Genes involved in Xenobiotics