Motif ID: NFATC2_NFATC3

Z-value: 0.890

Transcription factors associated with NFATC2_NFATC3:

Gene SymbolEntrez IDGene Name
NFATC2 ENSG00000101096.15 NFATC2
NFATC3 ENSG00000072736.14 NFATC3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC2hg19_v2_chr20_-_50159198_50159299-0.583.2e-03Click!
NFATC3hg19_v2_chr16_+_68119247_68119293-0.223.0e-01Click!


Activity profile for motif NFATC2_NFATC3.

activity profile for motif NFATC2_NFATC3


Sorted Z-values histogram for motif NFATC2_NFATC3

Sorted Z-values for motif NFATC2_NFATC3



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC2_NFATC3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_74372662 3.261 ENST00000591651.1
ENST00000545180.1
 SPHK1

sphingosine kinase 1

chr7_-_41742697 2.698 ENST00000242208.4
 INHBA
inhibin, beta A
chr15_+_45722727 2.162 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
 C15orf48


chromosome 15 open reading frame 48


chr2_-_190044480 1.911 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr4_-_123377880 1.719 ENST00000226730.4
 IL2
interleukin 2
chr11_-_123065989 1.662 ENST00000448775.2
 CLMP
CXADR-like membrane protein
chr7_-_121944491 1.649 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
 FEZF1


FEZ family zinc finger 1


chr3_-_141747950 1.622 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_86159821 1.601 ENST00000369651.3
 NT5E
5'-nucleotidase, ecto (CD73)
chr5_+_135394840 1.585 ENST00000503087.1
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr6_+_151662815 1.441 ENST00000359755.5
 AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_205391178 1.437 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr2_-_216003127 1.419 ENST00000412081.1
ENST00000272895.7
 ABCA12

ATP-binding cassette, sub-family A (ABC1), member 12

chr6_+_86159765 1.368 ENST00000369646.3
ENST00000257770.3
 NT5E

5'-nucleotidase, ecto (CD73)

chr12_-_52585765 1.300 ENST00000313234.5
ENST00000394815.2
 KRT80

keratin 80

chr1_+_209602609 1.291 ENST00000458250.1
 MIR205HG
MIR205 host gene (non-protein coding)
chr1_+_209602771 1.277 ENST00000440276.1
 MIR205HG
MIR205 host gene (non-protein coding)
chr8_+_70404996 1.244 ENST00000402687.4
ENST00000419716.3
 SULF1

sulfatase 1

chr20_+_33759854 1.230 ENST00000216968.4
 PROCR
protein C receptor, endothelial
chr6_+_15246501 1.216 ENST00000341776.2
 JARID2
jumonji, AT rich interactive domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 268 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0030574 collagen catabolic process(GO:0030574)
0.0 3.5 GO:0070268 cornification(GO:0070268)
1.1 3.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.4 3.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.7 3.0 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.5 3.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.9 2.7 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 2.6 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.6 1.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 1.9 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.3 1.9 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 1.8 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.4 1.7 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.3 1.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 1.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.4 1.4 GO:0035627 ceramide transport(GO:0035627)
0.1 1.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 1.4 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 1.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.9 2.7 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 2.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 2.4 GO:0008091 spectrin(GO:0008091)
0.0 2.3 GO:0045095 keratin filament(GO:0045095)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.6 1.9 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.2 1.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.4 1.3 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 1.3 GO:0045180 basal cortex(GO:0045180)
0.0 1.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.0 GO:0030057 desmosome(GO:0030057)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 0.9 GO:0045160 myosin I complex(GO:0045160)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 3.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 3.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 3.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.9 2.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 2.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.5 GO:0005518 collagen binding(GO:0005518)
0.4 2.4 GO:0004882 androgen receptor activity(GO:0004882)
0.2 2.4 GO:0042731 PH domain binding(GO:0042731)
0.3 2.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 2.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.4 1.4 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.3 1.3 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 1.3 GO:0001968 fibronectin binding(GO:0001968)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.2 GO:0033038 bitter taste receptor activity(GO:0033038)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 5.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.3 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.2 3.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 2.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.7 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 3.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 3.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 2.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 2.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 2.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.0 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.2 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.0 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.0 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins