Motif ID: NFATC4

Z-value: 1.054


Transcription factors associated with NFATC4:

Gene SymbolEntrez IDGene Name
NFATC4 ENSG00000100968.9 NFATC4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC4hg19_v2_chr14_+_24837226_24837547-0.424.3e-02Click!


Activity profile for motif NFATC4.

activity profile for motif NFATC4


Sorted Z-values histogram for motif NFATC4

Sorted Z-values for motif NFATC4



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_98703643 8.243 ENST00000477737.1
 VWA3B
von Willebrand factor A domain containing 3B
chr14_+_96949319 5.243 ENST00000554706.1
 AK7
adenylate kinase 7
chr1_-_161337662 4.268 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr11_+_101918153 3.652 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr14_+_96858433 3.102 ENST00000267584.4
 AK7
adenylate kinase 7
chr1_+_111889212 3.077 ENST00000369737.4
 PIFO
primary cilia formation
chr1_-_75139397 3.040 ENST00000326665.5
 C1orf173
chromosome 1 open reading frame 173
chr2_-_207629997 2.821 ENST00000454776.2
 MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr2_-_207630033 2.704 ENST00000449792.1
 MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr14_+_75536335 2.488 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
 ZC2HC1C



zinc finger, C2HC-type containing 1C



chr14_+_75536280 2.425 ENST00000238686.8
 ZC2HC1C
zinc finger, C2HC-type containing 1C
chr4_-_100356551 2.391 ENST00000209665.4
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr5_+_140254884 2.221 ENST00000398631.2
 PCDHA12
protocadherin alpha 12
chr10_-_116444371 2.217 ENST00000533213.2
ENST00000369252.4
 ABLIM1

actin binding LIM protein 1

chr9_-_80263220 2.196 ENST00000341700.6
 GNA14
guanine nucleotide binding protein (G protein), alpha 14
chr16_+_57769635 2.005 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
 KATNB1


katanin p80 (WD repeat containing) subunit B 1


chr12_-_71551652 1.949 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr11_-_62474803 1.925 ENST00000533982.1
ENST00000360796.5
 BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr21_-_34185944 1.914 ENST00000479548.1
 C21orf62
chromosome 21 open reading frame 62
chr1_-_159869912 1.909 ENST00000368099.4
 CCDC19
coiled-coil domain containing 19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
2.0 5.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.4 5.5 GO:0006108 malate metabolic process(GO:0006108)
0.2 2.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.5 2.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.6 1.9 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.5 1.9 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.1 1.9 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 1.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.3 1.7 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1 1.6 GO:0072189 ureter development(GO:0072189)
0.0 1.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 1.4 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.2 1.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 1.3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.4 1.2 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 1.2 GO:0006740 NADPH regeneration(GO:0006740)
0.1 1.2 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.1 1.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.7 GO:0005875 microtubule associated complex(GO:0005875)
0.1 2.3 GO:0035371 microtubule plus-end(GO:0035371)
0.2 1.9 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.8 GO:0005861 troponin complex(GO:0005861)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 1.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.4 GO:0071953 elastic fiber(GO:0071953)
0.1 1.4 GO:0097433 dense body(GO:0097433)
0.1 1.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.4 GO:1990391 DNA repair complex(GO:1990391)
0.2 1.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.4 1.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.0 1.1 GO:0042101 T cell receptor complex(GO:0042101)
0.2 1.0 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 1.0 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.5 GO:0004127 cytidylate kinase activity(GO:0004127)
1.5 5.9 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.8 5.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 3.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.3 2.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.5 1.8 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 1.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 1.3 GO:0008009 chemokine activity(GO:0008009)
0.4 1.2 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.2 GO:0000150 recombinase activity(GO:0000150)
0.0 1.2 GO:0031005 filamin binding(GO:0031005)
0.0 1.2 GO:0005521 lamin binding(GO:0005521)
0.2 1.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.2 1.1 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.1 1.0 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 1.0 GO:0004089 carbonate dehydratase activity(GO:0004089)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.6 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.5 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 2.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.8 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 1.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.7 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.2 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.1 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.0 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.0 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.6 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors