Motif ID: NFIL3

Z-value: 1.234


Transcription factors associated with NFIL3:

Gene SymbolEntrez IDGene Name
NFIL3 ENSG00000165030.3 NFIL3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFIL3hg19_v2_chr9_-_94186131_94186174-0.555.7e-03Click!


Activity profile for motif NFIL3.

activity profile for motif NFIL3


Sorted Z-values histogram for motif NFIL3

Sorted Z-values for motif NFIL3



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIL3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_70861647 7.642 ENST00000246895.4
ENST00000381060.2
 STATH

statherin

chr1_-_161337662 6.375 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr10_+_22634384 6.030 ENST00000376624.3
ENST00000376603.2
ENST00000376601.1
ENST00000538630.1
ENST00000456231.2
ENST00000313311.6
ENST00000435326.1
 SPAG6






sperm associated antigen 6






chr6_-_32557610 5.953 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr19_-_41388657 5.216 ENST00000301146.4
ENST00000291764.3
 CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr4_+_69962185 5.132 ENST00000305231.7
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr4_+_69962212 4.742 ENST00000508661.1
 UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr2_+_132286754 4.494 ENST00000434330.1
 CCDC74A
coiled-coil domain containing 74A
chr13_+_43355683 4.372 ENST00000537894.1
 FAM216B
family with sequence similarity 216, member B
chr13_-_39564993 4.312 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr4_+_69681710 4.218 ENST00000265403.7
ENST00000458688.2
 UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr19_-_41356347 3.870 ENST00000301141.5
 CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr19_+_41594377 3.558 ENST00000330436.3
 CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr5_-_35938674 3.439 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr5_-_149792295 3.420 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
 CD74



CD74 molecule, major histocompatibility complex, class II invariant chain



chr11_+_62104897 3.400 ENST00000415229.2
ENST00000535727.1
ENST00000301776.5
 ASRGL1


asparaginase like 1


chr2_+_132287237 3.343 ENST00000467992.2
 CCDC74A
coiled-coil domain containing 74A
chr6_+_150690028 3.228 ENST00000229447.5
ENST00000344419.3
 IYD

iodotyrosine deiodinase

chr12_+_7013897 3.225 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr12_+_7014064 3.209 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 315 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.5 9.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.5 7.6 GO:0046541 saliva secretion(GO:0046541)
1.1 7.4 GO:0009804 coumarin metabolic process(GO:0009804)
0.3 7.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 6.5 GO:0010107 potassium ion import(GO:0010107)
1.2 6.0 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.7 6.0 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
1.9 5.6 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 5.3 GO:0007286 spermatid development(GO:0007286)
0.5 5.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.4 4.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 4.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 3.5 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.7 3.4 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.4 3.4 GO:0006528 asparagine metabolic process(GO:0006528)
0.3 3.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 3.3 GO:0044458 motile cilium assembly(GO:0044458)
0.2 3.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.6 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.2 10.7 GO:0009925 basal plasma membrane(GO:0009925)
0.5 9.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 8.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 5.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
1.1 4.3 GO:0097224 sperm connecting piece(GO:0097224)
0.0 4.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 3.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.3 3.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 2.4 GO:0035580 specific granule lumen(GO:0035580)
0.1 2.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 1.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 1.8 GO:0036126 sperm flagellum(GO:0036126)
0.4 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 1.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.5 GO:0033270 paranode region of axon(GO:0033270)
0.2 1.4 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.4 GO:0097433 dense body(GO:0097433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 14.7 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.3 14.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
2.5 7.6 GO:0046848 hydroxyapatite binding(GO:0046848)
0.2 6.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 4.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 4.3 GO:0032027 myosin light chain binding(GO:0032027)
0.9 3.8 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 3.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.7 3.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.6 3.3 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 3.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 3.2 GO:0070888 E-box binding(GO:0070888)
1.0 3.0 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 3.0 GO:0008009 chemokine activity(GO:0008009)
0.6 2.5 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 2.4 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 2.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.3 2.2 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 2.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.8 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.1 ST_ADRENERGIC Adrenergic Pathway
0.1 1.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 1.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.1 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 1.0 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 0.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 14.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.5 9.5 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.3 6.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 4.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 3.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 2.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.3 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 2.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.9 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.7 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.5 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.3 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.1 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs