Motif ID: NFIX_NFIB

Z-value: 1.112

Transcription factors associated with NFIX_NFIB:

Gene SymbolEntrez IDGene Name
NFIB ENSG00000147862.10 NFIB
NFIX ENSG00000008441.12 NFIX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFIBhg19_v2_chr9_-_14180778_141808080.511.1e-02Click!
NFIXhg19_v2_chr19_+_13135386_131354350.395.9e-02Click!


Activity profile for motif NFIX_NFIB.

activity profile for motif NFIX_NFIB


Sorted Z-values histogram for motif NFIX_NFIB

Sorted Z-values for motif NFIX_NFIB



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX_NFIB

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_100354442 2.533 ENST00000475887.1
 GPR128
G protein-coupled receptor 128
chr4_-_16077741 2.424 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
 PROM1


prominin 1


chr17_+_1633755 2.262 ENST00000545662.1
 WDR81
WD repeat domain 81
chr2_-_158345462 2.208 ENST00000439355.1
ENST00000540637.1
 CYTIP

cytohesin 1 interacting protein

chr16_-_28621353 1.868 ENST00000567512.1
 SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr5_-_180018540 1.859 ENST00000292641.3
 SCGB3A1
secretoglobin, family 3A, member 1
chr20_+_31749574 1.841 ENST00000253362.2
 BPIFA2
BPI fold containing family A, member 2
chr6_+_43612750 1.819 ENST00000372165.4
ENST00000372163.4
 RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr20_+_31870927 1.617 ENST00000253354.1
 BPIFB1
BPI fold containing family B, member 1
chr4_+_15480828 1.598 ENST00000389652.5
 CC2D2A
coiled-coil and C2 domain containing 2A
chr11_+_101918153 1.548 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr17_+_68100989 1.502 ENST00000585558.1
ENST00000392670.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr9_+_127615733 1.470 ENST00000373574.1
 WDR38
WD repeat domain 38
chr3_+_100328433 1.459 ENST00000273352.3
 GPR128
G protein-coupled receptor 128
chr1_+_118148556 1.453 ENST00000369448.3
 FAM46C
family with sequence similarity 46, member C
chr1_-_161337662 1.446 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr2_+_26624775 1.428 ENST00000288710.2
 DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr22_-_36018569 1.423 ENST00000419229.1
ENST00000406324.1
 MB

myoglobin

chr1_+_230883179 1.413 ENST00000366666.2
 CAPN9
calpain 9
chr15_+_71228826 1.389 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
 LRRC49




leucine rich repeat containing 49





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 742 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 GO:0035082 axoneme assembly(GO:0035082)
0.3 6.0 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 6.0 GO:0001895 retina homeostasis(GO:0001895)
0.2 3.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.6 2.9 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.6 2.4 GO:2000768 positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 2.4 GO:0015671 oxygen transport(GO:0015671)
0.0 2.4 GO:0010107 potassium ion import(GO:0010107)
0.0 2.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.3 2.0 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 2.0 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 1.9 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 1.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 1.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 1.8 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 1.8 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.6 1.7 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.5 1.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 1.6 GO:0072313 metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2 4.1 GO:0036038 MKS complex(GO:0036038)
0.0 3.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 2.9 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.9 GO:0031526 brush border membrane(GO:0031526)
0.4 2.8 GO:0002177 manchette(GO:0002177)
0.1 2.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 2.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.0 GO:0031514 motile cilium(GO:0031514)
0.0 1.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.7 GO:0005844 polysome(GO:0005844)
0.2 1.6 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 1.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 1.5 GO:0016324 apical plasma membrane(GO:0016324)
0.5 1.4 GO:0005608 laminin-3 complex(GO:0005608)
0.1 1.4 GO:0005861 troponin complex(GO:0005861)
0.1 1.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 422 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 3.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 3.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 3.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 3.5 GO:0030246 carbohydrate binding(GO:0030246)
0.2 3.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 3.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.3 GO:0070330 aromatase activity(GO:0070330)
0.5 3.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 3.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 2.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.2 GO:0019843 rRNA binding(GO:0019843)
0.3 2.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 2.0 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.3 1.8 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 1.8 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 1.7 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 1.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 1.6 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 ST_ADRENERGIC Adrenergic Pathway
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.6 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.5 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.3 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.2 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.2 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 3.7 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 3.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.0 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.4 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.4 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 1.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 1.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres