Motif ID: NFKB2

Z-value: 0.544


Transcription factors associated with NFKB2:

Gene SymbolEntrez IDGene Name
NFKB2 ENSG00000077150.13 NFKB2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFKB2hg19_v2_chr10_+_104155450_1041554790.386.8e-02Click!


Activity profile for motif NFKB2.

activity profile for motif NFKB2


Sorted Z-values histogram for motif NFKB2

Sorted Z-values for motif NFKB2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_58131931 1.265 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr4_-_74864386 1.089 ENST00000296027.4
 CXCL5
chemokine (C-X-C motif) ligand 5
chr22_-_37640456 0.988 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
 RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr1_-_186649543 0.982 ENST00000367468.5
 PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr22_-_37640277 0.957 ENST00000401529.3
ENST00000249071.6
 RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr5_+_7654057 0.941 ENST00000537121.1
 ADCY2
adenylate cyclase 2 (brain)
chr8_+_86376081 0.841 ENST00000285379.5
 CA2
carbonic anhydrase II
chr1_-_6545502 0.779 ENST00000535355.1
 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chrX_+_103173457 0.771 ENST00000419165.1
 TMSB15B
thymosin beta 15B
chr3_-_50340996 0.743 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1





hyaluronoglucosaminidase 1





chr20_+_43803517 0.704 ENST00000243924.3
 PI3
peptidase inhibitor 3, skin-derived
chr4_+_17812525 0.700 ENST00000251496.2
 NCAPG
non-SMC condensin I complex, subunit G
chrX_+_64887512 0.647 ENST00000360270.5
 MSN
moesin
chr19_+_48824711 0.645 ENST00000599704.1
 EMP3
epithelial membrane protein 3
chr8_+_54793454 0.604 ENST00000276500.4
 RGS20
regulator of G-protein signaling 20
chr18_+_21529811 0.590 ENST00000588004.1
 LAMA3
laminin, alpha 3
chr3_+_111718173 0.580 ENST00000494932.1
 TAGLN3
transgelin 3
chr8_+_54793425 0.578 ENST00000522225.1
 RGS20
regulator of G-protein signaling 20
chr1_-_38100539 0.540 ENST00000401069.1
 RSPO1
R-spondin 1
chr19_-_41859814 0.512 ENST00000221930.5
 TGFB1
transforming growth factor, beta 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.3 1.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 1.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.0 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 0.9 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.9 GO:0006270 DNA replication initiation(GO:0006270)
0.3 0.8 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.8 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.8 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0 0.8 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.8 GO:0070207 protein homotrimerization(GO:0070207)
0.2 0.7 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.7 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.7 GO:0007620 copulation(GO:0007620)
0.0 0.7 GO:0006734 NADH metabolic process(GO:0006734)
0.2 0.6 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.1 0.6 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.6 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.9 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.9 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.9 GO:0045178 basal part of cell(GO:0045178)
0.1 0.8 GO:0070435 Shc-EGFR complex(GO:0070435)
0.1 0.7 GO:0000796 condensin complex(GO:0000796)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.0 0.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.5 GO:0045160 myosin I complex(GO:0045160)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.3 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.3 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.1 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 1.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.8 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 0.8 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.8 GO:0004568 chitinase activity(GO:0004568)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.4 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.4 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.4 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.5 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.4 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.0 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.0 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 0.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 0.8 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.7 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling