Motif ID: NKX1-1

Z-value: 0.342


Transcription factors associated with NKX1-1:

Gene SymbolEntrez IDGene Name
NKX1-1 ENSG00000235608.1 NKX1-1



Activity profile for motif NKX1-1.

activity profile for motif NKX1-1


Sorted Z-values histogram for motif NKX1-1

Sorted Z-values for motif NKX1-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX1-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_8822113 1.703 ENST00000396290.1
ENST00000331129.3
ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

chr12_+_7013897 1.200 ENST00000007969.8
ENST00000323702.5
LRRC23

leucine rich repeat containing 23

chr12_+_7014064 1.195 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr12_+_7014126 0.957 ENST00000415834.1
ENST00000436789.1
LRRC23

leucine rich repeat containing 23

chr13_+_36050881 0.806 ENST00000537702.1
NBEA
neurobeachin
chr19_+_32897009 0.699 ENST00000342179.5
ENST00000586427.1
DPY19L3

dpy-19-like 3 (C. elegans)

chr19_+_32896697 0.678 ENST00000586987.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr6_-_80247105 0.507 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chr10_+_120789223 0.428 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chr1_+_100818156 0.322 ENST00000336454.3
CDC14A
cell division cycle 14A
chr6_+_26501449 0.320 ENST00000244513.6
BTN1A1
butyrophilin, subfamily 1, member A1
chr4_-_103682145 0.265 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr11_-_105892937 0.263 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4



Myb/SANT-like DNA-binding domain containing 4 with coiled-coils



chr7_-_86849883 0.225 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr11_-_4629388 0.223 ENST00000526337.1
ENST00000300747.5
TRIM68

tripartite motif containing 68

chr2_+_217524323 0.218 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr6_-_167040731 0.197 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_108507631 0.196 ENST00000527011.1
ENST00000370056.4
VAV3

vav 3 guanine nucleotide exchange factor

chr3_+_186560462 0.188 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560476 0.188 ENST00000320741.2
ENST00000444204.2
ADIPOQ

adiponectin, C1Q and collagen domain containing


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.7 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.2 1.4 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.5 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.4 GO:2000583 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.4 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 0.3 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 0.2 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.0 0.1 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)

Gene overrepresentation in cellular_component category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.5 GO:0060091 kinocilium(GO:0060091)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0043295 glutathione binding(GO:0043295)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase