Motif ID: NKX1-2_RAX

Z-value: 0.551

Transcription factors associated with NKX1-2_RAX:

Gene SymbolEntrez IDGene Name
NKX1-2 ENSG00000229544.6 NKX1-2
RAX ENSG00000134438.9 RAX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RAXhg19_v2_chr18_-_56940611_56940660-0.184.0e-01Click!


Activity profile for motif NKX1-2_RAX.

activity profile for motif NKX1-2_RAX


Sorted Z-values histogram for motif NKX1-2_RAX

Sorted Z-values for motif NKX1-2_RAX



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX1-2_RAX

PNG image of the network

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Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_35938674 5.596 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr12_+_7013897 3.589 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr12_+_7014064 3.577 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr12_+_7014126 2.809 ENST00000415834.1
ENST00000436789.1
 LRRC23

leucine rich repeat containing 23

chr12_-_25348007 2.173 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr13_+_36050881 2.053 ENST00000537702.1
 NBEA
neurobeachin
chr5_-_20575959 1.339 ENST00000507958.1
 CDH18
cadherin 18, type 2
chr11_+_71900703 1.179 ENST00000393681.2
 FOLR1
folate receptor 1 (adult)
chr11_+_71900572 1.155 ENST00000312293.4
 FOLR1
folate receptor 1 (adult)
chr4_-_25865159 1.129 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
 SEL1L3



sel-1 suppressor of lin-12-like 3 (C. elegans)



chr4_+_77356248 1.121 ENST00000296043.6
 SHROOM3
shroom family member 3
chr11_-_63376013 0.826 ENST00000540943.1
 PLA2G16
phospholipase A2, group XVI
chr4_-_141348789 0.783 ENST00000414773.1
 CLGN
calmegin
chr2_+_217524323 0.745 ENST00000456764.1
 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr16_-_28608364 0.740 ENST00000533150.1
 SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_+_201979645 0.672 ENST00000367284.5
ENST00000367283.3
 ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr16_-_28608424 0.653 ENST00000335715.4
 SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr14_+_74034310 0.609 ENST00000538782.1
 ACOT2
acyl-CoA thioesterase 2
chr6_+_26402465 0.601 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
 BTN3A1





butyrophilin, subfamily 3, member A1





chr6_+_26440700 0.589 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3









butyrophilin, subfamily 3, member A3










Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 1.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 1.1 GO:0045176 apical protein localization(GO:0045176)
0.0 1.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.8 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.8 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.2 0.7 GO:2000583 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.7 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.7 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 0.5 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.4 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.1 0.3 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.1 0.3 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.5 GO:0060091 kinocilium(GO:0060091)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.1 0.4 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.3 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 1.4 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 0.8 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 0.5 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA