Motif ID: NKX2-1

Z-value: 0.524


Transcription factors associated with NKX2-1:

Gene SymbolEntrez IDGene Name
NKX2-1 ENSG00000136352.13 NKX2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36988882_36988898,
hg19_v2_chr14_-_36989427_36989442,
hg19_v2_chr14_-_36990354_36990397		0.359.1e-02Click!


Activity profile for motif NKX2-1.

activity profile for motif NKX2-1


Sorted Z-values histogram for motif NKX2-1

Sorted Z-values for motif NKX2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 197 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_31360887 1.190 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
 GALNT14


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)


chr15_+_40453204 1.119 ENST00000287598.6
ENST00000412359.3
 BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr16_+_66638003 0.893 ENST00000562357.1
ENST00000360086.4
ENST00000562707.1
ENST00000361909.4
ENST00000460097.1
ENST00000565666.1
 CMTM3





CKLF-like MARVEL transmembrane domain containing 3





chr20_-_36793663 0.832 ENST00000536701.1
ENST00000536724.1
 TGM2

transglutaminase 2

chr18_+_33877654 0.820 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3



formin homology 2 domain containing 3



chr11_-_62313090 0.755 ENST00000528508.1
ENST00000533365.1
 AHNAK

AHNAK nucleoprotein

chr6_+_32121789 0.745 ENST00000437001.2
ENST00000375137.2
 PPT2

palmitoyl-protein thioesterase 2

chr17_+_76210267 0.712 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
 BIRC5



baculoviral IAP repeat containing 5



chr5_-_146889619 0.700 ENST00000343218.5
 DPYSL3
dihydropyrimidinase-like 3
chr20_-_56285595 0.675 ENST00000395816.3
ENST00000347215.4
 PMEPA1

prostate transmembrane protein, androgen induced 1

chr11_+_35160709 0.675 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
 CD44











CD44 molecule (Indian blood group)











chr1_+_15736359 0.654 ENST00000375980.4
 EFHD2
EF-hand domain family, member D2
chr19_+_39903185 0.631 ENST00000409794.3
 PLEKHG2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr16_+_66638616 0.599 ENST00000564060.1
ENST00000565922.1
 CMTM3

CKLF-like MARVEL transmembrane domain containing 3

chr17_+_40610862 0.595 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
 ATP6V0A1








ATPase, H+ transporting, lysosomal V0 subunit a1








chr3_-_16524357 0.595 ENST00000432519.1
 RFTN1
raftlin, lipid raft linker 1
chr17_+_76210367 0.589 ENST00000592734.1
ENST00000587746.1
 BIRC5

baculoviral IAP repeat containing 5

chr4_+_144354644 0.588 ENST00000512843.1
 GAB1
GRB2-associated binding protein 1
chr8_+_70404996 0.579 ENST00000402687.4
ENST00000419716.3
 SULF1

sulfatase 1

chr6_+_32121218 0.576 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
 PPT2


palmitoyl-protein thioesterase 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 1.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 1.3 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 1.2 GO:0016266 O-glycan processing(GO:0016266)
0.3 1.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.2 1.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.3 0.8 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 0.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.6 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.6 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.6 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.2 0.5 GO:1905166 negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.1 0.5 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.5 GO:0048102 autophagic cell death(GO:0048102)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.9 GO:0031941 filamentous actin(GO:0031941)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)
0.1 0.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.5 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.4 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0043219 lateral loop(GO:0043219)
0.0 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 1.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.0 0.9 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.8 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.6 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.5 GO:1903135 cupric ion binding(GO:1903135)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.4 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.4 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.4 GO:0070324 thyroid hormone binding(GO:0070324)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.1 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.0 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.3 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.7 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly