Motif ID: NKX2-2

Z-value: 0.978


Transcription factors associated with NKX2-2:

Gene SymbolEntrez IDGene Name
NKX2-2 ENSG00000125820.5 NKX2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-2hg19_v2_chr20_-_21494654_214946780.135.6e-01Click!


Activity profile for motif NKX2-2.

activity profile for motif NKX2-2


Sorted Z-values histogram for motif NKX2-2

Sorted Z-values for motif NKX2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_61513146 3.004 ENST00000430431.1
 LINC00948
long intergenic non-protein coding RNA 948
chr10_-_61513201 2.338 ENST00000414264.1
ENST00000594536.1
 LINC00948

long intergenic non-protein coding RNA 948

chr1_+_104293028 2.131 ENST00000370079.3
 AMY1C
amylase, alpha 1C (salivary)
chr2_+_228736321 1.916 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr1_+_54359854 1.867 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
 DIO1





deiodinase, iodothyronine, type I





chr1_+_104159999 1.674 ENST00000414303.2
ENST00000423678.1
 AMY2A

amylase, alpha 2A (pancreatic)

chr15_-_56757329 1.519 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr1_+_78769549 1.451 ENST00000370758.1
 PTGFR
prostaglandin F receptor (FP)
chr12_-_49582978 1.447 ENST00000301071.7
 TUBA1A
tubulin, alpha 1a
chr1_-_26633067 1.428 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
 UBXN11








UBX domain protein 11








chr13_-_36429763 1.379 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr13_+_31506818 1.341 ENST00000380473.3
 TEX26
testis expressed 26
chr17_-_29641084 1.292 ENST00000544462.1
 EVI2B
ecotropic viral integration site 2B
chr13_-_61989655 1.288 ENST00000409204.4
 PCDH20
protocadherin 20
chr2_+_39103103 1.236 ENST00000340556.6
ENST00000410014.1
ENST00000409665.1
ENST00000409077.2
ENST00000409131.2
 MORN2




MORN repeat containing 2




chr17_+_7591639 1.232 ENST00000396463.2
 WRAP53
WD repeat containing, antisense to TP53
chr12_-_68696652 1.231 ENST00000539972.1
 MDM1
Mdm1 nuclear protein homolog (mouse)
chr17_+_7591747 1.227 ENST00000534050.1
 WRAP53
WD repeat containing, antisense to TP53
chr12_-_71551652 1.139 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr3_-_121379739 1.088 ENST00000428394.2
ENST00000314583.3
 HCLS1

hematopoietic cell-specific Lyn substrate 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0070986 left/right axis specification(GO:0070986)
0.8 2.5 GO:0032203 telomere formation via telomerase(GO:0032203)
0.1 2.2 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.1 1.9 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 1.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.2 1.7 GO:0044245 polysaccharide digestion(GO:0044245)
0.5 1.6 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.2 1.5 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 1.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 1.2 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 1.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 1.0 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.9 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.9 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 0.7 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.2 0.7 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 0.7 GO:0042780 tRNA 3'-end processing(GO:0042780)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.6 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.2 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.0 0.9 GO:0036038 MKS complex(GO:0036038)
0.0 0.9 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.8 GO:0042382 paraspeckles(GO:0042382)
0.1 0.7 GO:0034464 BBSome(GO:0034464)
0.0 0.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.6 GO:0098536 deuterosome(GO:0098536)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.3 GO:0072487 MSL complex(GO:0072487)
0.1 0.2 GO:0043159 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.3 1.9 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.4 1.7 GO:0016160 amylase activity(GO:0016160)
0.2 1.6 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.5 1.5 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.2 1.2 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.2 1.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 1.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.9 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.9 GO:0031005 filamin binding(GO:0031005)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 0.7 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.7 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.6 GO:0032052 bile acid binding(GO:0032052)
0.0 0.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.1 0.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.8 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 1.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.5 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.9 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.9 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.8 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C