Motif ID: NKX2-3

Z-value: 0.562


Transcription factors associated with NKX2-3:

Gene SymbolEntrez IDGene Name
NKX2-3 ENSG00000119919.9 NKX2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v2_chr10_+_101292684_101292706-0.387.0e-02Click!


Activity profile for motif NKX2-3.

activity profile for motif NKX2-3


Sorted Z-values histogram for motif NKX2-3

Sorted Z-values for motif NKX2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_150404904 2.910 ENST00000521632.1
 GPX3
glutathione peroxidase 3 (plasma)
chr1_-_205391178 1.337 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr19_-_51504852 1.331 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr3_+_98482175 1.189 ENST00000485391.1
ENST00000492254.1
 ST3GAL6

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

chr5_-_110848189 1.101 ENST00000296632.3
ENST00000512160.1
ENST00000509887.1
 STARD4


StAR-related lipid transfer (START) domain containing 4


chr19_-_19051993 1.096 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
 HOMER3



homer homolog 3 (Drosophila)



chr2_-_31440377 0.993 ENST00000444918.2
ENST00000403897.3
 CAPN14

calpain 14

chr4_-_57524061 0.890 ENST00000508121.1
 HOPX
HOP homeobox
chr3_+_101818088 0.832 ENST00000491959.1
 ZPLD1
zona pellucida-like domain containing 1
chr1_+_43824669 0.825 ENST00000372462.1
 CDC20
cell division cycle 20
chr11_+_35211429 0.801 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
 CD44


CD44 molecule (Indian blood group)


chr6_+_31126291 0.795 ENST00000376257.3
ENST00000376255.4
 TCF19

transcription factor 19

chr6_-_11382478 0.736 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
 NEDD9



neural precursor cell expressed, developmentally down-regulated 9



chr1_-_68962805 0.728 ENST00000370966.5
 DEPDC1
DEP domain containing 1
chr12_-_120315074 0.708 ENST00000261833.7
ENST00000392521.2
 CIT

citron (rho-interacting, serine/threonine kinase 21)

chr19_+_45409011 0.701 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
 APOE


apolipoprotein E


chrX_+_41548220 0.688 ENST00000378142.4
 GPR34
G protein-coupled receptor 34
chrX_+_41548259 0.679 ENST00000378138.5
 GPR34
G protein-coupled receptor 34
chr15_+_40674920 0.646 ENST00000416151.2
ENST00000249776.8
 KNSTRN

kinetochore-localized astrin/SPAG5 binding protein

chr14_-_50154921 0.614 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
 POLE2



polymerase (DNA directed), epsilon 2, accessory subunit




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.9 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 1.5 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.2 1.4 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.3 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 1.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 1.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 1.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 1.1 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 1.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.9 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.8 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 0.8 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.8 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 0.7 GO:2000646 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646)
0.1 0.7 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.7 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.1 GO:0045178 basal part of cell(GO:0045178)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 0.7 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.2 0.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.6 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.6 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.4 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0042588 zymogen granule(GO:0042588)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 GO:0008430 selenium binding(GO:0008430)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.2 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.1 1.1 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 1.1 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 0.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 0.8 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.8 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.7 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.7 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 0.6 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.2 0.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.6 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.5 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.4 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation